Washington Nationals vs Arizona Diamondbacks Prediction, Preview and Odds - 06/06/2026

Game Time: 4:10 pm ET, Saturday, June 6, 2026

Venue:  Chase Field, Phoenix, AZ

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Nationals +135, Diamondbacks -160; Over/Under:  9 runs

Bet365:  Moneyline odds:  Nationals +135, Diamondbacks -160; Over/Under:  9 runs

BetMGM:  Moneyline odds:  Nationals +130, Diamondbacks -155; Over/Under:  9 runs

Washington Nationals:  31-32 (3rd place, NL East)

Arizona Diamondbacks:  33-29 (2nd place, NL West)

Do not miss out on our expert handicapper analysis! ASA, Inc. is on a HOT STREAK in MLB on a 7-0 MLB RUN for +$7,130 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Washington Nationals:  5-5 last 10

Arizona Diamondbacks:  5-5 last 10

The Nationals are entering this series off a loss and got swept in their 3-game series against the Miami Marlins 3-0 in their last series. They enter this game with a 31-32 record overall and have a road record of 19-12. This is the 2nd game of a 3-game series with the Diamondbacks on Saturday with the series opener still to be played on Friday. Their offense ranks 6th in the MLB with a .733 OPS. Foster Griffin is their starting pitcher on Friday while Zack Littell is making his start in this game on Saturday. He is 5-4 with a 5.01 ERA this season. His team won their last 4 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 2 ER, 0 HR, and 2 BB with 5 SO on 5 hits through 6 IP against the San Diego Padres.

The Diamondbacks are entering this series off a win and split their 4-game series against the Los Angeles Dodgers 2-2 in their last series. They enter this game with a 33-29 record overall and have a home record of 20-12. This is the 2nd game of a 3-game series with the Nationals on Saturday with the series opener still to be played on Friday. Their offense ranks 19th in the MLB with a .703 OPS. Merrill Kelly is their starting pitcher on Friday while Eduardo Rodríguez is making his start in this game on Saturday. He is 5-1 with a 2.24 ERA this season. His team won their last 3 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 0 homers, and 1 walk with 3 strikeouts on 5 hits through 6 innings pitched against the Los Angeles Dodgers.

The current betting odds have the Diamondbacks listed as a favorite in this game according to Draftkings Sportsbook. The Nationals haven't looked great in their games this season with their 31-32 record overall which has them right in the middle of the NL East. They have been a much better road team though with their 19-12 road record this year. Meanwhile, the Diamondbacks have looked good in their games this season with their 33-29 record overall which has them right in the middle of the NL West. They have looked great in their own ballpark too with their 20-12 home record this season. The Diamondbacks are 5-5 in their last 10 games and they haven't looked great lately, but the Nationals are also 5-5 in their last 10 and haven't looked any better. The Nationals also just got swept at home by the Marlins in their last series while the Diamondbacks managed to split a 4-game series with the Dodgers, so they will have some momentum entering this series. They are also going to have the better pitching matchup in this one. Rodriguez is on the mound here for the Diamondbacks and he has looked great this season. He is 5-1 with a 2.24 ERA and his team has had a ton of success with him this season. They have won 3 games in a row now with him starting and he only gave up 1 earned run in his last start which has been a common theme for him all year. The Nationals are going with Littell in this one and he hasn't looked great this season. He is 5-4 with a 5.01 ERA and he has been giving up a lot of runs this year. He only gave up 2 earned runs in his last start which hasn't really been a common theme for him and the team has won 4 games in a row now with him starting too, but that isn't going to last with how bad he has been over the course of the season and the Nationals also have one of the worst bullpens in the league that will blow leads late. All signs point to the Diamondbacks taking this one at home. The best way to place a bet here is on the Diamondbacks to win this game. 

Nationals Diamondbacks Prediction:  Our MLB Pick for Saturday, June 6, 2026 (4:10 pm ET start time) is Diamondbacks 7 Nationals 1.

Don't miss our champion handicappers free picks, best bets, and expert baseball picks today.  And if you enjoyed this Washington Nationals Arizona Diamondbacks prediction, be sure to drop by every day for our daily MLB projections and previews.

Washington Nationals: 85-107 (+21.6 units) on the moneyline in road games. 136-181 (+20.8 units) on the moneyline as an underdog of +100 or higher. 100-120 (+6.7 units) on the moneyline vs. an NL team with a team batting average of .255 or worse. 42-29 OVER as a road underdog of +100 to +150.

Arizona Diamondbacks: 107-88 (-3.8 units) on the moneyline in home games. 106-82 (-10.8 units) on the moneyline as a favorite of -110 or higher. 90-74 (-4.9 units) on the moneyline when playing against a team with a losing record. 36-21 OVER as a home favorite of -150 or more.

Washington Nationals:  D. Millas (C) Day To Day - Lip. D. Crews (CF) Day To Day - Undisclosed. M. Kranick (RP) Sixty Day IL - Elbow. J. Irvin (SP) Fifteen Day IL - Shoulder. K. Waldichuk (SP) Sixty Day IL - Forearm. J. Gray (SP) Sixty Day IL - Elbow. D. Herz (SP) Sixty Day IL - Elbow. T. Williams (SP) Sixty Day IL - Elbow.

Arizona Diamondbacks:  I. Vargas (1B) Day To Day - Thigh. C. Santana (1B) Sixty Day IL - Groin. L. Gurriel Jr. (LF) Ten Day IL - Hamstring. J. McCann (C) Ten Day IL - Quad. J. Lawlar (LF) Sixty Day IL - Wrist. B. Walston (SP) Sixty Day IL - Elbow. C. Mena (SP) Sixty Day IL - Shoulder. A. Puk (RP) Sixty Day IL - Elbow. C. Burnes (SP) Sixty Day IL - Elbow. J. Martinez (RP) Sixty Day IL - Elbow. A. Saalfrank (RP) Sixty Day IL - Shoulder.

“I think the big blocks of creating a place, an environment where guys want to get better every single day … we’re seeing that. It’s starting to set that foundation. Now it’s just about making small improvements every single day to keep getting better.” - Blake Butera after his team got swept by the Marlins in their last series. 

“Those are the types of things that you see on the baseball field when two players are lying on the dirt after trying to make a hustle play. It tough to see, but they both got off the field.” - Torey Lovullo on the injury to Vargas after his team’s win against the LA Dodgers in their game on Thursday.

James Wood (L) DH

Dylan Crews (R) RF

Curtis Mead (R) 3B

CJ Abrams (L) SS

Jacob Young (R) CF

Daylen Lile (L) LF

Keibert Ruiz (S) C

Luis García Jr. (L) 1B

Nasim Nuñez (S) 2B

Ketel Marte (S) 2B

Corbin Carroll (L) RF

Gabriel Moreno (R) C

Nolan Arenado (R) 3B

Ryan Waldschmidt (R) CF

Ildemaro Vargas (S) 1B

Geraldo Perdomo (S) SS

Jose Fernandez (R) DH

Tommy Troy (R) LF

Batting Average:  CJ Abrams (.288)

Hits:  CJ Abrams (65)

Home Runs:  James Wood (16)

RBI:  CJ Abrams (47)

Stolen Bases:  Nasim Nuñez (22)

Wins:  Foster Griffin (6)

Saves:  Gus Varland (4)

ERA:  Orlando Ribalta (1.65)

Batting Average:  Jordan Lawlar (.333)

Hits:  Corbin Carroll (64)

Home Runs:  Ketel Marte (11)

RBI:  Ildemaro Vargas (37)

Stolen Bases:  Geraldo Perdomo (8)

Wins:  Michael Soroka (7)

Saves:  Paul Sewald (15)

ERA:  Brandyn Garcia (0.69)

Managers:

Washington Nationals: Blake Butera (1st season)

Arizona Diamondbacks: Torey Lovullo (10th season)