Vegas Golden Knights vs Anaheim Ducks Prediction, Preview and Odds - 11/22/2025

Game Time: 10:00 pm ET, Saturday, November 22, 2025

Venue:  Honda Center, Anaheim, CA

Where to Watch:  ESPN+

DraftKings:  Moneyline:  Knights -130, Ducks +110; Over/Under:  6.5 goals

Bet365:  Moneyline:  Knights -130, Ducks +110; Over/Under:  6 goals

BetMGM:  Moneyline:  Knights -130, Ducks +110; Over/Under:  6 goals

Vegas Golden Knights:  10-4-6 (2nd place, Pacific Division)

Anaheim Ducks:  13-7-1 (1st place, Pacific Division)

Do not miss out on our expert handicapper analysis! Doc’s Sports is on a HOT STREAK in the NHL on a 19-6 NHL RUN for +$12,630 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Vegas Golden Knights:  4-3-3 last 10

Anaheim Ducks:  6-4-0 last 10

The Golden Knights are entering this game with 26 points, a 10-4-6 record overall, and they are 5-1-3 in their road games this season where they will be in this game. They are entering this game off a win against the Utah Mammoth in their last game, winning that one on the road 4-1. Jack Eichel led the team in goals scored with 2 while Braeden Bowman and Ben Hutton each scored 1 goal for them in that one. Shea Theodore led the team in assists with 3 while Tomáš Hertl led the team in shots on net in that game with 6. Akira Schmid was the starting goalie in that game and he allowed 1 goal on 26 shots with 25 saves and a .962 save percentage. Their offense has scored 64 goals this season averaging 3.2 goals per game and their defense has allowed their opponents to score 56 goals against them allowing 2.8 goals per game.

The Ducks are entering this game with 27 points, a 13-7-1 record overall, and they are 7-2-0 in their home games this season where they will be in this game. They are entering this game off a loss against the Ottawa Senators in their last game, losing that one at home 3-2. Beckett Sennecke and Mason McTavish each scored 1 goal for them in that one. Chris Kreider, Cutter Gauthier, Leo Carlsson, and Troy Terry each led the team in assists with 1 while Mason McTavish led the team in shots on net in that game with 4. Petr Mrázek was the starting goalie in that game and he allowed 3 goals on 25 shots with 22 saves and a .880 sv percentage. Their offense has scored 76 goals this season averaging 3.6 goals per game and their defense has allowed their opponents to score 66 goals against them allowing 3.1 goals per game.

The current betting odds have the Golden Knights listed as a slight favorite in this game according to Draftkings Sportsbook. The Golden Knights have looked great in their games this season with their 10-4-6 record overall which has them right near the top of their division in the West. They have been a decent road team too with their 5-1-3 road record this year. Meanwhile, the Ducks have looked great in their games this season with their 13-7-1 record overall which has them right at the top of their division in the West. They have looked great on home ice too with their 7-2-0 home record this year. The Ducks got off to a really hot start that has put them at the top of the conference, but lately they have been starting to cool off. They are off a loss to the Senators in their last one and they haven't been scoring as many goals lately. They have one of the best offenses in the NHL right now, but they have also been giving up a ton of goals and that will be an issue here with the offense cooling off. The Golden Knights are only 4-3-3 in their last 10 games, but they have won 2 games in a row now and are starting to get hot, off a 4-1 road win over the Mammoth in their last one. Their offense has looked a lot better lately as they have been scoring more goals, and they haven't been giving up nearly as many goals as the Ducks all season. The best way to place a bet here is on the Golden Knights to win this game. 

Golden Knights Ducks Prediction:  Our NHL Pick for Saturday, November 22, 2025 (10:00 pm ET start time) is Knights 4 Ducks 2.

Don't miss our champion handicappers free picks and expert hockey picks today. And if you enjoyed this Vegas Golden Knights Anaheim Ducks prediction, be sure to drop by every day for our weekly NHL predictions and previews.

Vegas Golden Knights: 113-89 (-10.3 units) on the moneyline in all games. 54-49 (-16.9 units) on the moneyline as a favorite of -200 or less. 13-17 (-8.3 units) on the moneyline revenging a loss vs opponent as a home favorite. 26-16 UNDER when playing against a good team (Win Pct. 60% to 75%).

Anaheim Ducks: 75-109 (+10.3 units) on the moneyline in all games. 45-61 (+7 units) on the moneyline as an underdog of +100 to +200. 41-65 (+9.5 units) on the moneyline against explosive offensive teams - scoring 3+ goals/game. 21-7 UNDER when playing their 3rd game in 4 days.

Vegas Golden Knights:  J. Lauzon (D) Out - Undisclosed. A. Hill (G) Out - Lower-body. W. Karlsson (C) Out - Lower Body. M. Stone (RW) Out - Wrist.

Anaheim Ducks:  M. Granlund (C) Day To Day - Lower Body. R. Poehling (C) Day To Day - Upper-Body.

“We're not a great starting team, and Utah is. So for us to be even after 10 minutes was a good thing. We're getting better at it, each game we've been in the game quicker, so to speak… It helped getting those two quick goals, obviously that gives us life and takes the crowd out of a little bit.” - Bruce Cassidy after his team’s win against the Mammoth in their game on Thursday.

"He's dangerous. He's dangerous with the puck, he's dangerous off the rush, his play recognition. I think there are other parts of his game, when he's coming up with loose pucks, or he's influencing pucks, he's starting to do more of that." - Joel Quenneville on Sennecke after his team’s loss against the Senators in their game on Thursday.

LW Ivan Barbashev

C Jack Eichel

RW Braeden Bowman

LD Brayden McNabb

RD Shea Theodore

G Akira Schmid

LW Chris Kreider

C Leo Carlsson

RW Troy Terry

LD Jackson LaCombe

RD Drew Helleson

G Petr Mrazek

Points: Jack Eichel (27)

Goals: Pavel Dorofeyev (11)

Assists: Jack Eichel (17)

GAA: Akira Schmid (2.33)

Points: Leo Carlsson (28)

Goals: Cutter Gauthier (12)

Assists: Leo Carlsson (17)

GAA: Lukas Dostal (2.81)

Coaches:

Vegas Golden Knights: Bruce Cassidy (4th season)

Anaheim Ducks: Joel Quenneville (1st season)