Vanderbilt Commodores vs Tennessee Volunteers Prediction, Picks and Game Preview - 11/29/2025

Game Time: 3:30 pm ET, Saturday, November 29, 2025

Venue:  Neyland Stadium, Knoxville, TN

Where to Watch:  ESPN

DraftKings:  Point Spread:  Vanderbilt +3, Tennessee -3; Over/Under:  65.5 points

Bet365:  Point Spread:  Vanderbilt +2.5, Tennessee -2.5; Over/Under:  65.5 points

BetMGM:  Point Spread:  Vanderbilt +3, Tennessee -3; Over/Under:  65.5 points

Vanderbilt Commodores:  9-2 (5-2) (5th place, SEC)

Tennessee Volunteers:  8-3 (4-3) (8th place, SEC)

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Vanderbilt Commodores:  won their last game at home against the Kentucky Wildcats 45-17.

Tennessee Volunteers:  won their last game on the road against the Florida Gators 31-11.

Vanderbilt is entering this game with a 9-2 record overall and they have a 5-2 record in their conference games too. They are 7-0 in their home games, 2-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Kentucky 45-17. Diego Pavia was the starting QB and he completed 33/39 passes for 484 passing yards, 5 touchdowns, and 1 interception. Diego Pavia led the team in rushing yards with 48 and 1 TD. Tre Richardson led the receivers with 159 receiving yards on 6 receptions and 3 TDs. Dontae Carter led the defense in that game with 3 solo tackles and 0 assisted tackles while Khordae Sydnor led the defense in sacks with 1. Martel Hight came away with 2 interceptions while Kolbey Taylor came away with 1 INT for them in that one.

 

 

 

Tennessee is entering this game with an 8-3 record overall and they have a 4-3 record in their conference games too. They are 4-2 in their home games, 3-1 in their road games, and they are also 1-0 in their neutral site games this season, but they will be at home for this game. They won their last game against Florida 31-11. Joey Aguilar was the starting QB and he completed 17/22 passes for 204 passing yards, 1 touchdown, and 0 interceptions. DeSean Bishop led the team in rushing yards with 116 and 2 TDs. Ethan Davis led the receivers with 72 receiving yards on 5 receptions and 1 TD. Edwin Spillman led the defense in that game with 4 solo tackles and 3 assisted tackles while Edwin Spillman and Daevin Hobbs each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

The current betting odds have Tennessee listed as a 3 point favorite in this game according to Draftkings Sportsbook. Tennessee has looked good in their games this season with their 8-3 record overall and their 4-3 conference record which has them in the top half of the SEC. They have looked good on their home field too with their 4-2 home record this year. Meanwhile, Vanderbilt has looked great in their games this season with their 9-2 record overall and their 5-2 conference record which has them right near the top of the SEC. They haven't been a great road team though with their 2-2 road record this season. Vandy is off a 45-17 win over Kentucky in their last one and they have been rolling over teams all season, but they have also looked like a completely different team at home. Their offense has struggled a lot more in their road games and their defense hasn't looked great all season as they do give up a lot of points. That will be an issue here since they are going on the road against one of the best offenses in the SEC. Tennessee has also been beating up on bad teams all season, off a 31-11 win over Florida in their last one, and they have been putting up a ton of points in their games. They have a lot of momentum on their side right now after winning at Florida last week, something they haven't done in years, and now they have a chance to end their rival's season at home. Tennessee is pretty much out of the playoff picture with 3 losses, but Vandy is hanging around right on the edge so this is a great opportunity for Tennessee to put the final dagger in them. The best way to place a bet here is on Tennessee to cover the spread in this game. 

Vanderbilt Tennessee Prediction:  Our NCAAF Pick for Saturday, November 29, 2025 (3:30 pm ET start time) is Tennessee 38 Vanderbilt 30.

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Vanderbilt Commodores: 5-0 ATS when the line is +3 to -3. 3-0 ATS off a home win against a conference rival. 9-5 ATS versus good offensive teams - averaging 425 yards/game or more. 6-3 UNDER in games played on a grass field. 

Tennessee Volunteers: 0-4 ATS when the total is greater than or equal to 63. 4-9 ATS off a win against a conference rival. 3-8 ATS when playing against a top-level team (Win Pct. > 75%). 8-4 UNDER vs. good offensive  teams - scoring 31 or more points/game.

Vanderbilt Commodores:  V. Hinton (CB) Questionable - Undisclosed. D. Dickey (QB) Questionable - Undisclosed. N. Jefferson (DL) Questionable - Undisclosed. Y. Ouattara (DL) Questionable - Undisclosed. C. Gillespie (RB) Questionable - Undisclosed.

Tennessee Volunteers:  S. Walton (CB) Questionable - Undisclosed. P. Lewis (RB) Questionable - Undisclosed. M. Kitselman (TE) Questionable - Undisclosed. J. Dodson (WR) Questionable - Undisclosed. R. Gibson III (CB) Out - Undisclosed. J. McCoy (CB) Out - Knee.

“He’s the best player in the country and deserves to be in the Heisman conversation. He tips the field when he steps on it. There’s only a few players in the world that when the ball’s in your hand that they can take over a game, and he’s done that repeatedly here.” - Clark Lea on Diego Pavia after his team’s win against Kentucky in their last game. 

“This one mattered to them. It was a lot of fun inside that locker room. It was important to them. They understood the history of this rivalry. We've talked about that. It was fun to see them enjoy this moment.” - Josh Heupel after his team’s win against Florida in their last game. 

WR Sherrill, Junior

WR Richardson, Tre

WR Hoskins, Richie

TE Stowers, Eli

QB Pavia, Diego

RB Alexander, Sedrick

WR Matthews, Mike

WR Brazzell II, Chris

WR Staley, Braylon

TE Kitselman, Miles

QB Aguilar, Joey

RB Bishop, DeSean

Passing: Diego Pavia (2,924)

Rushing: Diego Pavia (661)

Receiving: Eli Stowers (705)

Touchdowns: Sedrick Alexander (12)

Passing: Joey Aguilar (3,145)

Rushing: DeSean Bishop (886)

Receiving: Chris Brazzell II (926)

Touchdowns: DeSean Bishop (12)

Coaches:

Vanderbilt Commodores: Clark Lea (5th season)

Tennessee Volunteers: Josh Heupel (5th season)