Vanderbilt Commodores vs Missouri Tigers Prediction, Picks and Game Preview - 02/18/2026

Game Time: 9:00 pm ET, Wednesday, February 18, 2026

Venue:  Mizzou Arena, Columbia, MO

Where to Watch:  SEC Network

DraftKings:  Point Spread:  Vandy -3.5, Mizzou +3.5; Over/Under:  153.5 points

Bet365:  Point Spread:  Vandy -3.5, Mizzou +3.5; Over/Under:  153.5 points

BetMGM:  Point Spread:  Vandy -3.5, Mizzou +3.5; Over/Under:  153.5 points

Vanderbilt Commodores:  21-4 (8-4) (3rd place, SEC)

Missouri Tigers:  17-8 (7-5) (7th place, SEC)

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Vanderbilt Commodores:  4-1  last 5

Missouri Tigers:  3-2  last 5

Vanderbilt is entering this game with a 21-4 record overall, an 8-4 record in conference games, and they are 6-2 in their road games this season where they will be in this game. They are coming off a win against the Texas A&M Aggies in their last game. Tyler Nickel led the team in points in that game with 25 while AK Okereke was next on the team with 23. Tyler Tanner led the team in assists with 6 in that game while Devin McGlockton and Jalen Washington each led the team in rebounds with 8. They were 43.9% from the field, 31% from 3-point range, and 79.3% from the free throw line with their shooting in that game. Their offense is averaging 88.4 PPG and their defense is allowing their opponents to average 73.6 PPG against them. Vanderbilt has an ATS record of 14-11 this season and their O/U record is 11-14.

Missouri is entering this game with a 17-8 record overall, a 7-5 conference record, and they are 13-2 in their home games this season where they will be in this game. They are coming off a loss against the Texas Longhorns in their last game. Jayden Stone and Mark Mitchell each led the team in points in that game with 16 while Anthony Robinson II was next on the team with 11. T.O. Barrett, Trent Pierce, and Anthony Robinson II each led the team in assists with 2 in that game while Jayden Stone led the team in rebounds with 5. They were 42.2% from the field, 40% from 3-point range, and 68.4% from the free throw line with their shooting in that game. Their offense is averaging 80 PPG and their defense is allowing their opponents to average 74.3 PPG against them. Missouri has an ATS record of 10-15 this season and their O/U record is 11-13-1.

The current betting odds have Vanderbilt listed as a 3.5 point favorite in this game according to Draftkings Sportsbook. Vanderbilt has looked great in their games this season with their 21-4 record overall and their 8-4 conference record which has them in the top half of the SEC. They have been a great road team too with their 6-2 road record this year. Meanwhile, Missouri has looked good in their games this season with their 17-8 record overall and their 7-5 conference record which has them in the top half of the SEC. They have looked great on their home court too with their 13-2 home record this season. As good as Missouri has looked on their home court this year, they are only 3-2 in their last 5 games and they are off a double digit home loss to Texas in their last one. They have been really up and down all season with some good games against good opponents, but also some bad games against some of the weaker opponents. This is a big step up for them in competition too with the hot start that Vandy got off to this season, and Vanderbilt has looked like one of the best teams in the SEC all year. They are off a double digit win over Texas A&M in their last one and they have been rolling again lately with 2 wins in a row now, also going 4-1 in their last 5. They haven't had a lot of trouble in road games either so Vanderbilt should be able to pick up a solid road win here as they are the more talented team and have been a lot more consistent this year. The best way to place a bet here is on Vanderbilt to cover the spread in this game. 

Vanderbilt Missouri Prediction:  Our NCAAB Pick for Wednesday, February 18, 2026 (9:00 pm ET start time) is Vanderbilt 82 Missouri 75.

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Vanderbilt Commodores: 6-3 ATS as a road favorite or pick. 22-16 ATS when playing against a good team (Win Pct. 60% to 80%). 7-2 UNDER as a road favorite or pick. 23-16 UNDER when playing against a good team (Win Pct. 60% to 80%). 21-13 UNDER versus good rebounding teams - outrebounding opponents by 4+ per game.

Missouri Tigers: 20-32 ATS in all home games. 11-20 ATS off a loss against a conference rival. 3-10 ATS off an upset loss as a favorite. 9-5 UNDER versus good passing teams, averaging 16 assists/game or more. 

Vanderbilt Commodores:  D. Miles (G) Questionable - Knee. F. Collins (G) Questionable - Knee. G. Kimble (G) Out - Knee.

Missouri Tigers:  S. Mack (G) Questionable - Illness. A. Boateng (G) Out - Leg. J. Porter (F) Questionable - Lower Leg.

“It says he doesn’t have to go out and get 20 for us to win. Other guys are capable. This team celebrates with each other. No one’s happier in that locker room than Tyler Tanner. And that’s why I like this group. They care about winning and they care about each other.” - Mark Byington after his team’s win against Texas A&M in their last game. 

“Big fellow, Matas, played 25 minutes. Shawn played 18. And that difference gives you an advantage because of size, ability and things like that, and we wanted to keep those minutes sort of the same, and Shawn even playing more, but that foul trouble hurt him. Still had to play him with two fouls in the first and he managed to get away with no foul. But, again, subbing in and out, he doesn't get a rhythm. And, ultimately, what I wish is that those two could play the whole game, because it was a good game to be played.” - Dennis Gates after his team’s loss against Texas in their last game. 

D. McGlockton 

D. Miles 

T. Nickel 

A. Okereke 

T. Tanner

S. Mack 

M. Mitchell 

S. Phillips 

J. Porter 

A. Robinson

PPG: Tyler Tanner (18.3)

APG: Tyler Tanner (5.4)

Reb/G: Devin McGlockton (6.9)

PPG: Mark Mitchell (17.2)

APG: Mark Mitchell (3.4)

Reb/G: Mark Mitchell (5.6)

Coaches:

Vanderbilt Commodores: Mark Byington (2nd season)

Missouri Tigers: Dennis Gates (4th season)