USC Trojans vs Oregon Ducks Prediction, Picks and Game Preview - 11/22/2025

Game Time: 3:30 pm ET, Saturday, November 22, 2025

Venue:  Autzen Stadium, Eugene, OR

Where to Watch:  CBS

DraftKings:  Point Spread:  USC +9.5, Oregon -9.5; Over/Under:  59.5 points

Bet365:  Point Spread:  USC +9.5, Oregon -9.5; Over/Under:  59.5 points

BetMGM:  Point Spread:  USC +9.5, Oregon -9.5; Over/Under:  59.5 points

USC Trojans:  8-2 (6-1) (4th place, Big Ten)

Oregon Ducks:  9-1 (6-1) (3rd place, Big Ten)

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USC Trojans:  won their last game at home against the Iowa Hawkeyes 26-21.

Oregon Ducks:  won their last game at home against the Minnesota Golden Gophers 42-13.

USC is entering this game with an 8-2 record overall and they have a 6-1 record in their conference games too. They are 6-0 in their home games, 2-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Iowa 26-21. Jayden Maiava was the starting QB and he completed 23/32 passes for 254 passing yards, 1 touchdown, and 0 interceptions. King Miller led the team in rushing yards with 83. Makai Lemon led the receivers with 153 receiving yards on 10 receptions and 1 TD. DeCarlos Nicholson led the defense in that game with 5 solo tackles and 2 assisted tackles while no one on the defense recorded a sack for them. Jahkeem Stewart came away with the only interception for them in that one.

 

 

 

Oregon is entering this game with a 9-1 record overall and they have a 6-1 record in their conference games too. They are 5-1 in their home games, 4-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against Minnesota 42-13. Dante Moore was the starting QB and he completed 27/30 passes for 306 passing yards, 2 touchdowns, and 0 interceptions. Noah Whittington led the team in rushing yards with 72 and 1 TD. Kenyon Sadiq led the receivers with 96 receiving yards on 8 receptions and 1 TD. Bryce Boettcher led the defense in that game with 3 solo tackles and 3 assisted tackles while Brandon Finney Jr. and Teitum Tuioti each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

The current betting odds have Oregon listed as a 9.5 point favorite in this game according to Draftkings Sportsbook. Oregon has looked great in their games this season with their 9-1 record overall and their 6-1 conference record which has them right near the top of the Big Ten. They are currently ranked inside the top 10 teams in the nation, but this is a really big game for their playoff hopes. Meanwhile, USC has looked really good in their games this season with their 8-2 record overall and their 6-1 conference record which has them right near the top of the Big Ten. They are currently ranked inside the top 25 teams in the nation and they do have a path to the CFP, but they are on the outside looking in at the moment. They are off a 26-21 win over Iowa in their last one and they struggled in that game as they were trailing for a while. Oregon also struggled with Iowa the week before, but Oregon was on the road in that one while USC was at home. USC hasn't been a great road team this year either with their 2-2 road record, and they definitely don't have the talent on defense that Oregon has. That defense is going to be an issue for USC as they have been giving up a ton of points all year against weaker offenses so this Oregon offense is going to light them up at home. Oregon is also in the playoff picture, but they are closer to the edge so this is a big opportunity for them to pick up a good win and improve their resume. The best way to place a bet here is on Oregon to cover the spread in this game. 

USC Oregon Prediction:  Our NCAAF Pick for Saturday, November 22, 2025 (3:30 pm ET start time) is Oregon 42 USC 27.

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USC Trojans: 3-11 ATS in road lined games. 3-11 ATS off a win against a conference rival. 0-6 ATS vs. good passing defenses - allowing 150 or less passing yards/game. 10-1 UNDER as a road underdog of 7.5 to 14 points. 30-14 UNDER in a road game where the total is between 56.5 and 63.

Oregon Ducks: 23-14 ATS in all lined games. 8-4 ATS when the total is between 56.5 and 63. 8-4 ATS off a home win by 17 points or more. 5-0 UNDER as a favorite of 3.5 to 10 points. 14-7 UNDER after a win by 17 or more points.

USC Trojans:  W. Jordan (RB) Doubtful - Ankle. A. Beavers Jr. (LB) Questionable - Undisclosed. P. Brown (CB) Questionable - Undisclosed. J. Jarrett (DL) Questionable - Undisclosed. J. Reed (OG) Questionable - Undisclosed. H. Dalton III (RB) Questionable - Undisclosed. C. Chittenden (K) Questionable - Undisclosed. E. Sanders (RB) Out - Knee. C. Johnson (CB) Out - Knee.

Oregon Ducks:  G. Wilson (OG) Questionable - Undisclosed. D. Riggs (RB) Questionable - Undisclosed. J. Ressler (WR) Questionable - Undisclosed. D. Moore (WR) Questionable - Knee. J. Limar (RB) Questionable - Undisclosed. S. Laulea (CB) Questionable - Undisclosed. D. Gresham (WR) Questionable - Undisclosed. G. Bryant Jr. (WR) Questionable - Ankle. T. Gray (DL) Questionable - Undisclosed. K. Kasper (WR) Out - Undisclosed. M. Hughes (RB) Out - Redshirt. B. Boulton (OG) Out - Undisclosed. E. Stewart (WR) Out - Knee. T. McNutt (CB) Out - Leg.

“Getting points on that first drive (after halftime) was big, and we just got on a run from there. It just felt like we were going to stop them every time. Felt like we were going to score every time. The energy in that room at halftime, I felt very strongly we were going to come back out and make a run.” - Lincoln Riley after his team’s win against Iowa in their last game. 

“He (Moore) can't throw it and catch it. We had some guys who did a great job of catching it tonight. He certainly threw it in some tight coverages and guys made plays. So great performance by our QB. Been impressed with him all year.” - Dan Lanning after his team’s win against Minnesota in their last game. 

WR Lane, Ja'Kobi

WR Hines, Tanook

WR Lemon, Makai

TE McRee, Lake

QB Maiava, Jayden

RB Miller, King

WR Benson, Malik

WR Moore, Dakorien

WR Bryant Jr., Gary

TE Sadiq, Kenyon

QB Moore, Dante

RB Whittington, Noah

Passing: Jayden Maiava (2,868)

Rushing: King Miller (719)

Receiving: Makai Lemon (1,090)

Touchdowns: Makai Lemon (10)

Passing: Dante Moore (2,190)

Rushing: Noah Whittington (623)

Receiving: Dakorien Moore (443)

Touchdowns: Jordon Davison (12)

Coaches:

USC Trojans: Lincoln Riley (4th season)

Oregon Ducks: Dan Lanning (4th season)