USC Trojans vs Nebraska Cornhuskers Prediction, Picks and Game Preview - 11/01/2025

Game Time: 7:30 pm ET, Saturday, November 1, 2025

Venue:  Memorial Stadium, Lincoln, NE

Where to Watch:  NBC

DraftKings:  Point Spread:  USC -6, Nebraska +6; Over/Under:  58.5 points

Bet365:  Point Spread:  USC -6, Nebraska +6; Over/Under:  59 points

BetMGM:  Point Spread:  USC -6.5, Nebraska +6.5; Over/Under:  59.5 points

USC Trojans:  5-2 (3-1) (6th place, Big Ten)

Nebraska Cornhuskers:  6-2 (3-2) (8th place, Big Ten)

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USC Trojans:  lost their last game on the road against the Notre Dame Fighting Irish 34-24.

Nebraska Cornhuskers:  won their last game at home against the Northwestern Wildcats 28-21.

USC is entering this game with a 5-2 record overall and they have a 3-1 record in their conference games too. They are 4-0 in their home games, 1-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against Notre Dame 34-24. Jayden Maiava was the starting QB and he completed 22/42 passes for 328 passing yards, 2 touchdowns, and 2 interceptions. King Miller led the team in rushing yards with 70. Ja'Kobi Lane led the receivers with 111 receiving yards on 6 receptions and 1 TD. Bishop Fitzgerald and Desman Stephens II each led the defense in that game with 7 solo tackles and 2 assisted tackles while Kameryn Fountain led the defense in sacks with 1. Braylan Shelby came away with the only interception for them in that one.

 

 

 

Nebraska is entering this game with a 6-2 record overall and they have a 3-2 record in their conference games too. They are 4-1 in their home games, 1-1 in their road games, and they are also 1-0 in their neutral site games this season, but they will be at home for this game. They won their last game against Northwestern 28-21. Dylan Raiola was the starting QB and he completed 16/22 passes for 141 passing yards, 1 touchdown, and 1 interception. Emmett Johnson led the team in rushing yards with 124 and 2 TDs. Nyziah Hunter led the receivers with 70 receiving yards on 6 receptions and 1 TD. Rex Guthrie led the defense in that game with 5 solo tackles and 3 assisted tackles while no one on the defense recorded a sack for them. Donovan Jones and Javin Wright each came away with 1 interception for them in that one.

The current betting odds have Nebraska listed as a 6 point underdog in this game according to Draftkings Sportsbook. Nebraska has looked really good in their games this season with their 6-2 record overall and their 3-2 conference record which has them higher in the Big Ten. They are off a 28-21 win over Northwestern in their last one and they have looked good on their home field all season with their 4-1 home record. Meanwhile, USC has looked good in their games this season with their 5-2 record overall and their 3-1 conference record which has them right near the top of the Big Ten. They are off a 34-24 loss on the road to Notre Dame in their last one and they haven't been a great road team this year with their 1-2 road record. They will be looking to bounce back as they are also coming out of their bye week, but this is a big game for both teams as the loser will likely be eliminated from playoff contention. USC has a great offense that has been putting up a lot of points this year, but that defense has still been an issue for them. They have been giving up a lot of points in their games all season and they haven't looked nearly as good in their road games either. Nebraska's defense hasn't been as good as advertised, but they are still better than USC's defense and that is going to be a key factor in this game with the home advantage. The best way to place a bet here is on Nebraska to cover the spread in this game. 

USC Nebraska Prediction:  Our NCAAF Pick for Saturday, November 1, 2025 (7:30 pm ET start time) is Nebraska 31 USC 28.

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USC Trojans: 8-4 ATS after 1 or more consecutive straight up losses. 5-2 ATS off a road loss. 20-12 OVER in all lined games. 9-3 OVER after playing their last game on the road. 13-5 OVER when playing against a team with a winning record. 7-3 OVER vs. good offensive  teams - scoring 31 or more points/game.

Nebraska Cornhuskers: 6-14 ATS against conference opponents. 1-5 ATS off a win against a conference rival. 2-10 ATS when playing against a team with a winning record. 8-4 OVER off a home win. 4-1 OVER off a home win against a conference rival.

USC Trojans:  K. O'Connor (OG) Questionable - Undisclosed. P. Brown (CB) Questionable - Undisclosed. F. Boucard (DL) Questionable - Undisclosed. C. Chittenden (K) Questionable - Undisclosed. J. Jarrett (DL) Questionable - Undisclosed. E. Sanders (RB) Out - Knee. W. Jordan (RB) Out - Ankle. E. Paige (OG) Questionable - Undisclosed. C. Johnson (CB) Out - Knee.

Nebraska Cornhuskers:  T. Terry (DL) Questionable - Undisclosed. J. Parker (RB) Questionable - Undisclosed. J. Marks (OG) Questionable - Undisclosed. D. Bell (WR) Questionable - Knee. M. Hartzog Jr. (CB) Questionable - Undisclosed. G. Gottula (OG) Questionable - Undisclosed. C. Connealy (DL) Out - Undisclosed. N. Fennessy (OG) Out - Undisclosed. M. Simpson (DL) Out - Undisclosed. T. Uhlir (RB) Out - Undisclosed. J. Bonner (WR) Out - Undisclosed. G. Pyle (OG) Out - Knee. B. Hill (CB) Out - Knee. G. Stenger (LB) Out - Undisclosed. M. Markway (TE) Out - Knee.

"We just flat out did not play good enough tonight against a good team on the road and had some missed opportunities that make you sick." - Lincoln Riley after his team’s loss against Notre Dame in their last game. 

“Our guys showed tremendous resolve. Any time you had that third quarter we had and you let them back in the game, that could be ‘Here we go again.' The first two years I was here, it would have been like that." - Matt Rhule after his team’s win against NW in their last game. 

WR Lane, Ja'Kobi

WR Hines, Tanook

WR Lemon, Makai

TE McRee, Lake

QB Maiava, Jayden

RB Jordan, Waymond

WR Hunter, Nyziah

WR Key, Dane

WR Barney Jr., Jacory

TE Lindenmeyer, Luke

QB Raiola, Dylan

RB Johnson, Emmett

Passing: Jayden Maiava (2,180)

Rushing: Waymond Jordan (576)

Receiving: Makai Lemon (758)

Touchdowns: Makai Lemon (7)

Passing: Dylan Raiola (1,909)

Rushing: Emmett Johnson (837)

Receiving: Nyziah Hunter (525)

Touchdowns: Emmett Johnson (10)

Coaches:

USC Trojans: Lincoln Riley (4th season)

Nebraska Cornhuskers: Matt Rhule (3rd season)