USC Trojans vs Indiana Hoosiers Prediction, Picks and Game Preview - 11/14/2026

Game Time: 3:30 pm ET, Saturday, November 14, 2026

Venue:  Memorial Stadium, Bloomington, IN

Where to Watch:  CBS

DraftKings:  Point Spread:  USC +7.5, Indiana -7.5; Over/Under:  50.5 points

Bet365:  Point Spread:  USC +7.5, Indiana -7.5; Over/Under:  50.5 points

BetMGM:  Point Spread:  USC +7.5, Indiana -7.5; Over/Under:  50.5 points

USC Trojans:  7-2 (4-2) (7th place, Big Ten)

Indiana Hoosiers:  8-1 (5-1) (2nd place, Big Ten)

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USC Trojans:  won their last game at home against the Ohio State Buckeyes 30-18.

Indiana Hoosiers:  won their last game at home against the Minnesota Golden Gophers 23-16 in overtime. 

USC is entering this game with a 7-2 record overall and they have a 4-2 record in their conference games too. They are 5-1 in their home games, 2-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Ohio State 30-18. Jayden Maiava was the starting QB and he completed 15/22 passes for 222 passing yards, 1 touchdown, and 0 interceptions. King Miller led the team in rushing yards with 78 and 1 TD. Trent Mosley led the receivers with 101 receiving yards on 5 receptions and 1 TD. Deven Bryant led the defense in that game with 8 tackles while Braylan Shelby led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

 

 

 

Indiana is entering this game with an 8-1 record overall and they have a 5-1 record in their conference games too. They are 5-1 in their home games, 3-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against Minnesota 23-16 in OT. Josh Hoover was the starting QB and he completed 8/19 passes for 119 passing yards, 1 touchdown, and 1 interception before getting replaced by Grant Wilson who completed 9/17 passes for 156 yards and 1 TD. Lee Beebe Jr. led the team in rushing yards with 84. Charlie Becker led the receivers with 149 receiving yards on 8 receptions and 1 TD. Preston Zachman led the defense in that game with 6 tackles while Byron Baldwin Jr., Tobi Osunsanmi, Jeff Utzinger, and Mario Landino each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

The current betting odds have Indiana listed as a 7.5 point favorite in this game according to Draftkings Sportsbook. Indiana has looked great in their games this season with their 8-1 record overall and their 5-1 conference record which has them right near the top of the Big Ten. They have looked great on their home field too with their 5-1 home record this season. Meanwhile, USC has looked good in their games this season with their 7-2 record overall and their 4-2 conference record which has them in the top half of the Big Ten. They have been a good road team too with their 2-1 road record this year. USC has found ways to win on the road this year, but they have struggled a lot on the road in the Big Ten and even those wins didn't come easy. They had a lot of trouble beating weaker opponents in Rutgers and Penn State, and their 1 road loss was terrible as they couldn't do anything on offense against Wisconsin. USC has had a great offense all season, but they haven't been putting up points against better defenses and they are going to see one of the best defenses in the Big Ten here. They do have some momentum since they are coming out of their bye week after beating Ohio State 30-18 in their last one, but that was an Ohio State team missing their starting QB and they have looked lifeless in 2 games without him. USC doesn't have a great defense either and they have been giving up a lot of points to weaker opponents all year. Indiana has had a lot of trouble on offense this season themselves with Hoover not looking great, but they are also coming out of their bye week and had 2 weeks to fix things. They are going to have a better game on offense with the way this USC defense has looked all season and Indiana still has a great defense to lean on for the win. Look for Indiana to come out of their bye week strong and really make a statement that they are still the team to beat in the Big Ten. The best way to place a bet here is on Indiana to cover the spread in this game. 

USC Indiana Prediction:  Our NCAAF Pick for Saturday, November 14, 2026 (3:30 pm ET start time) is Indiana 24 USC 14.

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USC Trojans: 3-10 ATS in road lined games. 4-10 ATS off a win against a conference rival. 5-10 ATS vs. good teams - outscoring opponents by 10+ PPG on the season. 7-2 OVER vesus good rushing teams - averaging 4.75 rushing yards/carry or more. 

Indiana Hoosiers: 13-6 ATS off a home win. 7-3 ATS off a home win against a conference rival. 9-3 ATS vs. good passing teams averaging 8 or more passing yards/att. 14-7 OVER when the total is between 49.5 and 56. 14-5 OVER off a home win.

USC Trojans:  M. Bowman (TE) Questionable - Undisclosed. K. Reddick (S) Questionable - Undisclosed. D. Redeaux (RB) Questionable - Undisclosed. R. Ison (WR) Questionable - Undisclosed. S. Huard (QB) Questionable - Undisclosed. R. Tezeno (WR) Questionable - Foot. T. Anderson (WR) Out - Undisclosed. C. Simms (WR) Out - Knee. K. O'Connor (OG) Out - Undisclosed.

Indiana Hoosiers:  K. Martin (RB) Questionable - Forearm.

“That's two of the best teams in the country on the field right there. It's going to come down to who plays the situations best, and we did it tonight.” - Lincoln Riley after his team’s win against OSU in their last game. 

“This is entertainment, so I thought we'd bring some entertainment to this game. Minnesota played great and we just made some plays, but this team just finds a way (to win).” - Curt Cignetti after his team’s win against Minnesota in their last game. 

WR Hines, Tanook

WR Dixon-Wyatt, Kayden

WR Mosley, Trent

TE Bowman, Mark

QB Maiava, Jayden

RB Miller, King

WR Marsh, Nick

WR Becker, Charlie

WR Morris, Tyler

TE Gibbs, Trevor

QB Hoover, Josh

RB Richard, Turbo

Passing: Jayden Maiava (2,524)

Rushing: King Miller (680)

Receiving: Trent Mosley (512)

Touchdowns: Trent Mosley (6)

Passing: Josh Hoover (1,860)

Rushing: Turbo Richard (745)

Receiving: Charlie Becker (875)

Touchdowns: Charlie Becker (9)

Coaches:

USC Trojans: Lincoln Riley (5th season)

Indiana Hoosiers: Curt Cignetti (3rd season)