USC Trojans vs Colorado Buffaloes Prediction, Picks and Game Preview - 09/30/2023

by Rod Pearson

Monday, Sep 25, 2023
Game Time: 12:00 pm ET, Saturday, September 30, 2023
Venue:  Folsom Field, Boulder, CO
Where to Watch:  FOX


Opening Odds at USA Sportsbooks

DraftKings:  Point Spread:  USC -22, Colorado +22; Over/Under:  73.5 points
Bet365:  Point Spread:  USC -22, Colorado +22; Over/Under:  73.5 points
BetMGM:  Point Spread:  USC -22.5, Colorado +22.5; Over/Under:  73.5 points

Season Record

USC Trojans:  4-0 (2-0) (1st place, Pac-12)
Colorado Buffaloes:  3-1 (0-1) (8th place, Pac-12)

Do not miss out on our expert handicapper analysis! Kyle Hunter is on a HOT STREAK in the NCAAF as he is 74-33 his last 107 CFB plays! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Recent Form
USC Trojans:  won their last game on the road against the Arizona State Sun Devils 42-28.
Colorado Buffaloes:  lost their last game on the road against the Oregon Ducks 42-6.


USC Trojans vs Colorado Buffaloes Preview and Analysis


USC is entering this game with a 4-0 record overall and they have a 2-0 record in their conference games too. They are 3-0 in their home games, 1-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Arizona State 42-28. Caleb Williams was the starting QB and he completed 20/31 passes for 322 passing yards, 3 touchdowns, and 0 interceptions. MarShawn Lloyd led the team in rushing yards with 154. Brenden Rice led the receivers with 133 receiving yards on 7 receptions and 2 TDs. Solomon Byrd led the defense in that game with 5 solo tackles and 0 assisted tackles while Solomon Byrd, Romello Height, and Tackett Curtis each led the defense in sacks with 2. Calen Bullock came away with the only interception for them in that game.
 
 
 
Colorado is entering this game with a 3-1 record overall and they have a 0-1 record in their conference games too. They are 2-0 in their home games, 1-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against Oregon 42-6. Shedeur Sanders was the starting QB and he completed 23/33 passes for 159 passing yards, 1 touchdown, and 0 interceptions. Anthony Hankerson led the team in rushing yards with 31. Xavier Weaver led the receivers with 75 receiving yards on 9 receptions. Shilo Sanders led the defense in that game with 6 solo tackles and 1 assisted tackle while Cam'Ron Silmon and Jordan Domineck each led the defense in sacks with 1. Jahquez Robinson came away with the only interception for them in that game.


USC vs Colorado Prediction

The current betting odds have Colorado listed as a 22 point underdog in this game according to Draftkings Sportsbook. Colorado was embarrassed by Oregon in their last game which was also the start of their conference play. Now they are back at home and they will be looking to bounce back after that loss. They have the advantage of the altitude in this game and it is also a really early start time so they can catch USC off guard in this game. USC is 4-0 this season but they haven't looked great in their games. Their defense has given up a ton of points in their games this year and they looked terrible in their 1st road conference game last week. They barely beat a banged up ASU team by 14 points and now they are on the road again but this time they are playing a better team with a chip on their shoulder and something to prove after getting blown out last week. Colorado didn't do much against Oregon but USC doesn't have a good defense so Colorado will get their opportunities to move the ball and put up points in this home game. The best way to place a bet here is on Colorado to cover the spread in this game.

USC Colorado Prediction:  Our NCAAF Pick for Saturday, September 30, 2023 (12:00 pm ET start time) is USC 41 Colorado 28.
Don't miss our champion handicappers free picks and expert football picks today. And if you enjoyed this USC Trojans Colorado Buffaloes prediction, be sure to drop by every day for our weekly NCAAF predictions and previews.

NCAAF Betting Trends


USC Trojans: 19-10 ATS after scoring 35 points or more in a win over a conference rival. 30-18 ATS off 2 consecutive wins by 10 points or more against conference rivals. 8-3 ATS after scoring 37 points or more in 4 straight games. 21-9 OVER in all games. 12-4 OVER when the total is greater than or equal to 63.

Colorado Buffaloes: 10-18 ATS in all games. 8-15 ATS as an underdog. 8-2 OVER off a road loss. 12-3 OVER after a loss by 17 or more points. 12-6 OVER after a game where they forced 1 or less turnovers.

Key Injuries


USC Trojans:  R. Brown (WR) day-to-day - Undisclosed.

Colorado Buffaloes:  X. Weaver (WR) day-to-day - Undisclosed. M. Slusher (S) day-to-day - Undisclosed. T. Hunter (CB) Mid Oct - Undisclosed. L. Passarello (TE) Out indefinitely - Knee.

Notable Quotes


“I thought we stepped up in a tough environment there at the very end and played our best ball in the fourth quarter, which that’s what you've got to do. It certainly wasn't our cleanest performance.” - Lincoln Riley after his team’s win against ASU in their last game. 


“Good old-fashioned butt-kicking. No excuses, no nothing.” - Deion Sanders after his team’s loss against Oregon in their last game.


Starting Lineups


USC Trojans
WR Hudson, Kyron 
WR Singer, Dorian 
WR Williams, Mario 
TE McRee, Lake 
QB Williams, Caleb 
RB Jones, Austin

Colorado Buffaloes
WR Hunter, Travis 
WR Weaver, Xavier 
WR Horn Jr., Jimmy 
TE Harrison, Michael 
QB Sanders, Shedeur 
RB Edwards, Dylan 

Statistical Leaders


USC Trojans
Passing: C. Williams (1200)
Rushing: M. Lloyd (349)
Receiving: T. Washington (278)
Touchdowns: B. Rice (5)

Colorado Buffaloes
Passing: S. Sanders (1410)
Rushing: D. Edwards (157)
Receiving: X. Weaver (461)
Touchdowns: D. Edwards (4)

Coaches:
USC Trojans: Lincoln Riley (2nd season)
Colorado Buffaloes: Deion Sanders (1st season)


Rod Pearson

About the Author:

Rod Pearson has been a rabid sports fan his entire life.  He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years.  In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective.  Join Rod every day as he breaks down the games to find the best betting value.

All photographic images used for editorial content have been licensed from the Associated Press.

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