Toronto Blue Jays vs San Diego Padres Prediction, Preview and Odds - 07/10/2026

Game Time: 9:40 pm ET, Friday, July 10, 2026

Venue:  Petco Park, San Diego, CA

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Blue Jays -105, Padres -115; Over/Under:  7.5 runs

Bet365:  Moneyline odds:  Blue Jays -105, Padres -115; Over/Under:  7.5 runs

BetMGM:  Moneyline odds:  Blue Jays -105, Padres -115; Over/Under:  7.5 runs

Toronto Blue Jays:  44-49 (3rd place, AL East)

San Diego Padres:  46-46 (2nd place, NL West)

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Toronto Blue Jays:  5-5 last 10

San Diego Padres:  3-7 last 10

The Blue Jays are entering this series off a win and won their 3-game series against the San Francisco Giants 2-1 in their last series. They enter this game with a 44-49 record overall and have a road record of 20-24. This is the series opener of a 3-game series with the Padres on Friday and they have Thursday off as a day of rest. Their offense ranks 27th in the MLB with a .688 OPS. Dylan Cease was their starting pitcher on Wednesday while Shane Bieber is making his start in this game on Friday. He is 0-1 with a 9.00 ERA this season. His team lost their last 3 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 7 ER, 2 HR, and 3 BB with 3 SO on 6 hits through 4 IP against the Seattle Mariners.

The Padres lost their 4-game series against the Los Angeles Dodgers 3-1. They enter this game with a 46-46 record overall and have a home record of 25-22. This is the 1st game of a 3-game series with the Blue Jays on Friday with the series finale of their series against the Arizona Diamondbacks still to be played on Thursday. The Padres lost the series opener on Monday, won the 2nd game on Tuesday, and won the 3rd game on Wednesday. Their offense ranks 30th in the MLB with a .674 OPS. Griffin Canning is their starting pitcher on Thursday while JP Sears is making his start in this game on Friday. He is 2-1 with a 4.70 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 0 earned runs, 0 homers, and 2 walks with 5 strikeouts on 1 hit through 5 innings pitched against the Los Angeles Dodgers.

The current betting odds have the Padres listed as a slight favorite in this game according to Draftkings Sportsbook. The Padres haven't looked great in their games this season with their 46-46 record overall, but that record has them right near the top of the NL West. They have looked a lot better in their own ballpark though with their 25-22 home record this season. Meanwhile, the Blue Jays haven't looked great in their games this season with their 44-49 record overall which has them right in the middle of the AL East. They haven't been a good road team either with their 20-24 road record this year. The Padres haven't looked great lately, going 3-7 in their last 10 games while the Blue Jays are 5-5 in their last 10, but the Padres are going to have the better pitching matchup here and can take advantage of that at home where they have looked better this season. The Padres are going with Sears in this one and he hasn't looked great this season. He is 2-1 with a 4.70 ERA, but lately he has looked a lot better. He is coming off a great start in which he gave up no runs which has been starting to become a common theme for him lately, and even the team has had more success now, winning 2 of their last 3 games with him starting. The Blue Jays are going with Bieber in this one and he hasn't looked good this season. He is 0-1 with a 9.00 ERA and he has been battling with injuries too. He is coming off a terrible start in which he gave up 7 earned runs and the team has been having trouble with him lately too, losing 3 games in a row now with him starting. The Padres have been in a slump lately, but they looked better against the Diamondbacks in their last series and this is a good opportunity for them to pick up another win at home with this pitching matchup. The best way to place a bet here is on the Padres to win this game. 

Blue Jays Padres Prediction:  Our MLB Pick for Friday, July 10, 2026 (9:40 pm ET start time) is Padres 5 Blue Jays 1.

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Toronto Blue Jays: 222-213 (-5.3 units) on the moneyline in all games. 100-114 (-5 units) on the moneyline in road games. 48-50 (-7.9 units) on the moneyline vs. an NL team with a team batting average of .255 or worse. 3-1 UNDER after scoring 10 runs or more.

San Diego Padres: 235-192 (+22.3 units) on the moneyline in all games. 125-88 (+9.7 units) on the moneyline in home games. 171-138 (+17 units) on the moneyline against right-handed starters. 49-35 UNDER vs. an AL team with a slugging percentage .410 or worse on the season.

Toronto Blue Jays:  J. Sanchez (RF) Ten Day IL - Ankle. M. Scherzer (SP) Fifteen Day IL - Back. J. Mantiply (RP) Sixty Day IL - Knee. L. Sosa (2B) Ten Day IL - Wrist. J. Berrios (SP) Sixty Day IL - Elbow. A. Barger (RF) Ten Day IL - Elbow. C. Ponce (SP) Sixty Day IL - Knee. A. Santander (RF) Sixty Day IL - Shoulder. Y. Garcia (RP) Sixty Day IL - Elbow. B. Francis (SP) Sixty Day IL - Elbow.

San Diego Padres:  M. Machado (3B) Day To Day - Foot. S. Taylor (LF) Ten Day IL - Oblique. F. Fermin (C) Ten Day IL - Head. R. Vasquez (SP) Fifteen Day IL - Ankle. J. Adam (RP) Fifteen Day IL - Shoulder. D. Morgan (RP) Fifteen Day IL - Knee. L. Giolito (SP) Fifteen Day IL - Elbow. J. Estrada (RP) Fifteen Day IL - Knee. R. Laureano (LF) Sixty Day IL - Hip. N. Pivetta (SP) Sixty Day IL - Elbow. M. Waldron (SP) Fifteen Day IL - Arm. B. Hoeing (RP) Sixty Day IL - Elbow. J. Musgrove (SP) Sixty Day IL - Elbow.

“I’m a fan of baseball. If a guy has a chance to throw a no-hitter, you let him do it, and I think you make the adjustments after that. Dylan, he’s done it before, and he’s really durable. He’s in the category where you can be pretty aggressive with it. It’s not very often you get to see that, so if I can let a player have that opportunity, I’m going to do it every single time.” - John Schneider after his team’s win against the Giants in their game on Wednesday. 

“That’s what we hoped for from Campy, getting a chance this year and bringing his bat into the lineup. The last few years with our catching situation, we’ve had great catchers, but offense hasn’t been their No. 1 thing. Campy is bringing the ability to leave the yard, to get a big hit any time he comes to the plate. He’s swinging with confidence, playing with confidence. It’s fun to see.” - Craig Stammen after his team’s win against the Diamondbacks in their game on Wednesday.

Ernie Clement (R) 2B

Nathan Lukes (L) RF

Vladimir Guerrero Jr. (R) 1B

George Springer (R) DH

Daulton Varsho (L) CF

Kazuma Okamoto (R) 3B

Alejandro Kirk (R) C

Jonatan Clase (S) LF

Andrés Giménez (L) SS

Fernando Tatis Jr. (R) RF

Jackson Merrill (L) CF

Xander Bogaerts (R) SS

Gavin Sheets (L) 1B

Jake Cronenworth (L) 2B

Luis Campusano (R) C

Miguel Andujar (R) DH

Jase Bowen (R) LF

Sung-Mun Song (L) 3B

Batting Average:  Luis Urías (.316)

Hits:  Ernie Clement (102)

Home Runs:  Kazuma Okamoto (21)

RBI:  Kazuma Okamoto (59)

Stolen Bases:  Andrés Giménez (10)

Wins:  Dylan Cease (6)

Saves:  Louis Varland (18)

ERA:  Simeon Woods Richardson (0.00)

Batting Average:  Samad Taylor (.330)

Hits:  Fernando Tatis (101)

Home Runs:  Manny Machado (18)

RBI:  Manny Machado (51)

Stolen Bases:  Fernando Tatis (23)

Wins:  Randy Vásquez (6)

Saves:  Mason Miller (23)

ERA:  Jhony Brito (0.00)

Managers:

Toronto Blue Jays: John Schneider (5th season)

San Diego Padres: Craig Stammen (1st season)