Toronto Blue Jays vs New York Yankees Prediction, Preview and Odds - 08/22/2026

Game Time: 1:35 pm ET, Saturday, August 22, 2026

Venue:  Yankee Stadium, Bronx, NY

Where to Watch:  ESPN Unlimited, MLB TV

DraftKings:  Moneyline odds:  Blue Jays +102, Yankees -122; Over/Under:  7 runs

Bet365:  Moneyline odds:  Blue Jays +100, Yankees -120; Over/Under:  7 runs

BetMGM:  Moneyline odds:  Blue Jays +100, Yankees -120; Over/Under:  7 runs

Toronto Blue Jays:  63-66 (4th place, AL East)

New York Yankees:  72-55 (2nd place, AL East)

Do not miss out on our expert handicapper analysis! Amedeus Mastrangelo is on a HOT STREAK in MLB on a 17-11 MLB RUN for +$5,390 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Toronto Blue Jays:  7-3 last 10

New York Yankees:  6-4 last 10

The Blue Jays are entering this series off a win and won their 3-game series against the Tampa Bay Rays 2-1 in their last series. They enter this game with a 63-66 record overall and have a road record of 30-33. This is the 2nd game of a 3-game series with the Yankees on Saturday with the series opener still to be played on Friday. Their offense ranks 28th in the MLB with a .685 OPS. Mason Fluharty is their starting pitcher on Friday while Dylan Cease is making his start in this game on Saturday. He is 7-5 with a 2.42 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season appearance, he allowed 2 ER, 0 HR, and 3 BB with 10 SO on 2 hits through 6.1 IP against the New York Yankees.

The Yankees are entering this series off a win and completed the sweep in their 3-game series against the Baltimore Orioles 3-0 in their last series. They enter this game with a 72-55 record overall and have a home record of 31-27. This is the 2nd game of a 3-game series with the Blue Jays on Saturday with the 1st game of this series still to be played on Friday. Their offense ranks 16th in the MLB with a .717 OPS. Cam Schlittler is their starting pitcher on Friday while Ryan Weathers is making his start in this game on Saturday. He is 5-7 with a 3.56 ERA this season. His team won their last 3 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 0 homers, and 1 walk with 4 strikeouts on 6 hits through 7.1 innings pitched against the Toronto Blue Jays.

The current betting odds have the Yankees listed as a slight favorite in this game according to Draftkings Sportsbook. The Yankees have looked really good in their games this season with their 72-55 record overall which has them right near the top of the AL East. They have looked good in their own ballpark too with their 31-27 home record this season. Meanwhile, the Blue Jays haven't looked good in their games this season with their 63-66 record overall which has them right near the bottom of the AL East. They haven't been a good road team either with their 30-33 road record this year. The Blue Jays are 7-3 in their last 10 games and they have been rolling lately, playing themselves back into the AL Wild Card race, but the Yankees are also 6-4 in their last 10 games and have been getting hot again, sweeping the Orioles in their last series. Weathers is on the mound for the Yankees in this one and he has looked good this season. He is 5-7 with a 3.58 ERA and the team has been having a lot of success with him lately. He is coming off a great start in which he gave up 1 earned run and the team has won 3 games in a row now with him starting too. The Blue Jays are going with Cease in this one and he has looked great this season. He is 7-5 with a 2.42 ERA and he has been their ace this year. He is coming off another great start giving up 2 earned runs which has been a common theme for him, but the team has not had a lot of success with him lately. They have lost 2 of their last 3 games with him starting and as good as Cease has been this year, the bullpen hasn't been great. The Yankees have one of the best bullpens in the league to lean on too and they have the much stronger offense here. The best way to place a bet here is on the Yankees to win this game. 

Blue Jays Yankees Prediction:  Our MLB Pick for Saturday, August 22, 2026 (1:35 pm ET start time) is Yankees 3 Blue Jays 2.

Don't miss our champion handicappers free picks, best bets, and expert baseball picks today.  And if you enjoyed this Toronto Blue Jays New York Yankees prediction, be sure to drop by every day for our daily MLB projections and previews.

Toronto Blue Jays: 129-128 (+15.5 units) on the moneyline when playing against a team with a winning record. 74-75 (+10.4 units) on the moneyline vs. teams outscoring opp by 0.5 or more runs/game on the season. 70-64 (+16.9 units) on the moneyline vs. good power teams - averaging 1.25 or more HR's/game. 29-21 UNDER when the total is 7 to 7.5.

New York Yankees: 270-201 (-17.6 units) on the moneyline in all games. 132-100 (-29.3 units) on the moneyline in home games. 76-73 (-20.9 units) on the moneyline against division opponents. 42-23 UNDER when the money line is -100 to -150.

Toronto Blue Jays:  A. Gimenez (SS) Day To Day - Hamstring. B. Bateman (CF) Day To Day - Hamstring. V. Guerrero Jr. (1B) Seven Day IL - Head. J. Bloss (SP) Sixty Day IL - Elbow. J. Taillon (SP) Fifteen Day IL - Forearm. L. Urias (2B) Ten Day IL - Quadriceps. T. Yesavage (SP) Fifteen Day IL - Knee. P. Corbin (SP) Sixty Day IL - Shoulder. S. Arrighetti (SP) Fifteen Day IL - Foot. A. Barger (RF) Sixty Day IL - Elbow. J. Clase (LF) Ten Day IL - Foot. J. Mantiply (RP) Sixty Day IL - Knee. J. Berrios (SP) Sixty Day IL - Elbow. C. Ponce (SP) Sixty Day IL - Knee. A. Santander (RF) Sixty Day IL - Shoulder. Y. Garcia (RP) Sixty Day IL - Elbow. B. Francis (SP) Sixty Day IL - Elbow.

New York Yankees:  R. McMahon (3B) Day To Day - Thumb. M. Fried (SP) Fifteen Day IL - Elbow. K. Castro (RP) Fifteen Day IL - Elbow. C. Bellinger (LF) Ten Day IL - Leg. A. Judge (RF) Sixty Day IL - Rib. G. Stanton (DH) Ten Day IL - Leg. C. Schmidt (SP) Sixty Day IL - Elbow.

“They're not backing down from it. I think that they all understand where we are in the season, and they are all kind of just stepping up. We’ve got versatile guys, and they kind of accepted the challenge today.” - John Schneider after his team’s win against the Rays in their game on Thursday. 

“Great way to finish a road trip.” - Aaron Boone after his team’s win against the Orioles in their game on Thursday. 

Charles McAdoo (R) 3B

Daz Cameron (R) LF

Alejandro Kirk (R) C

George Springer (R) DH

Kazuma Okamoto (R) 1B

Andrés Giménez (L) SS

Ernie Clement (R) 2B

Myles Straw (R) CF

Nathan Lukes (L) RF

Trent Grisham (L) CF

Ben Rice (L) DH

Heliot Ramos (R) LF

Luis García Jr. (L) 1B

Jazz Chisholm Jr. (L) 2B

George Lombard Jr. (R) SS

Spencer Jones (L) RF

Austin Wells (L) C

José Caballero (R) 3B

Batting Average:  Daz Cameron (.364)

Hits:  Ernie Clement (136)

Home Runs:  Kazuma Okamoto (26)

RBI:  Kazuma Okamoto (74)

Stolen Bases:  Andrés Giménez (19)

Wins:  Dylan Cease (7)

Saves:  Louis Varland (28)

ERA:  Tanner Andrews (0.00)

Batting Average:  George Lombard (.292)

Hits:  Ben Rice (114)

Home Runs:  Ben Rice (34)

RBI:  Ben Rice (80)

Stolen Bases:  Jazz Chisholm (33)

Wins:  Cam Schlittler (10)

Saves:  David Bednar (29)

ERA:  Yerry De los Santos (0.64)

Managers:

Toronto Blue Jays: John Schneider (5th season)

New York Yankees: Aaron Boone (9th season)