Game Time: 1:10 pm ET, Thursday, June 26, 2025
Venue: Progressive Field, Cleveland, OH
Where to Watch: MLBN Alt
Opening Odds at USA Sportsbooks
DraftKings: Moneyline odds: Blue Jays -108, Guardians -112; Over/Under: 8.5 runs
Bet365: Moneyline odds: Blue Jays -110, Guardians -110; Over/Under: 8 runs
BetMGM: Moneyline odds: Blue Jays -110, Guardians -110; Over/Under: 8 runs
Season Record
Toronto Blue Jays: 42-36 (3rd place, AL East)
Cleveland Guardians: 39-38 (2nd place, AL Central)
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Toronto Blue Jays: 4-6 last 10
Cleveland Guardians: 4-6 last 10
Toronto Blue Jays vs Cleveland Guardians Preview and Analysis
The Blue Jays are entering this series off a loss and lost their 3-game series against the Chicago White Sox 2-1 in their last series. They enter this game with a 42-36 record overall and have a road record of 17-20. This is the series finale of a 3-game series with the Guardians on Thursday with the 2nd game still to be played on Wednesday. The Blue Jays won the series opener on Tuesday. Their offense ranks 11th in the MLB with a .728 OPS. Max Scherzer is their starting pitcher on Wednesday while Kevin Gausman is making his start in this game on Thursday. He is 5-6 with a 4.60 ERA this season. His team lost their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 7 ER, 2 HR, and 3 BB with 4 SO on 7 hits through 4.1 IP against the Arizona Diamondbacks.
The Guardians are entering this series off a win and won their 3-game series against the Athletics 2-1 in their last series. They enter this game with a 39-38 record overall and have a home record of 19-16. This is the 3rd game of a 3-game series with the Blue Jays on Thursday with the 2nd game of this series still to be played on Wednesday. The Guardians lost the 1st game of this series on Tuesday. Their offense ranks 26th in the MLB with a .673 OPS. Gavin Williams is their starting pitcher on Wednesday while Tanner Bibee is making his start in this game on Thursday. He is 4-7 with a 3.86 ERA this season. His team lost their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 4 earned runs, 1 homer, and 0 walks with 10 strikeouts on 11 hits through 8 innings pitched against the Athletics.
Blue Jays vs Guardians Prediction
The current betting odds have the Guardians listed as a slight favorite in this game according to Draftkings Sportsbook. The Blue Jays have looked good in their games this season with their 42-36 record overall which has them right in the middle of the AL East. They haven't been a great road team though with their 17-20 road record. Meanwhile, the Guardians have looked good in their games this season with their 39-38 record overall which has them right in the middle of the AL Central. They have looked better in their own ballpark too with their 19-16 home record. Neither team has been great in their games lately as both teams are 4-6 in their last 10 games, and the Guardians do have the better pitching matchup here to get the edge in this one at home. Bibee is on the mound for the Guardians here and he hasn't looked bad this year. He is 4-7 with a 3.86 ERA and he did give up 4 earned runs in his last start, but he hasn't been giving up a ton of runs in his starts lately and he will be looking to bounce back at home. Gausman is on the mound for the Blue Jays and he hasn't looked that great lately. He is 5-6 with a 4.60 ERA and he has been giving up a ton of runs in his starts lately. His team has lost 2 games in a row with him starting as he hasn't been pitching well in June, and he also gave up 7 earned runs in his last start. The Blue Jays have the better offense, but they haven't looked that great lately and the Guardians can definitely take advantage of this pitching matchup. The best way to place a bet here is on the Guardians to win this game.
Blue Jays Guardians Prediction: Our MLB Pick for Thursday, June 26, 2025 (1:10 pm ET start time) is Guardians 6 Blue Jays 4.
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MLB Betting Trends
Toronto Blue Jays: 41-38 (-8 units) on the moneyline against AL Central opponents. 204-199 (-25.1 units) on the moneyline in all games. 102-110 (-10.4 units) on the moneyline when the money line is +125 to -125. 47-29 UNDER against AL Central opponents.
Cleveland Guardians: 42-44 (+3.7 units) on the moneyline against AL East opponents. 114-87 (+9 units) on the moneyline in home games. 59-44 (+15.3 units) on the moneyline at home when the money line is +125 to -125. 172-123 UNDER vs. good fielding teams - averaging 0.6 errors/game or less.
Key Injuries
Toronto Blue Jays: B. Francis (SP) Fifteen Day IL - Shoulder. D. Varsho (CF) Ten Day IL - Hamstring. A. Santander (RF) Ten Day IL - Shoulder. Y. Garcia (RP) Fifteen Day IL - Shoulder. M. Scherzer (SP) Sixty Day IL - Thumb. R. Burr (RP) Sixty Day IL - Shoulder. A. Manoah (SP) Sixty Day IL - Elbow. A. Bastardo (SP) Sixty Day IL - Elbow.
Cleveland Guardians: A. Walters (RP) Sixty Day IL - Lat. B. Lively (SP) Sixty Day IL - Forearm. W. Brennan (RF) Ten Day IL - Forearm. P. Sewald (RP) Fifteen Day IL - Shoulder. S. Bieber (SP) Sixty Day IL - Elbow. E. Sabrowski (RP) Sixty Day IL - Elbow. T. Stephan (RP) Sixty Day IL - Elbow. J. Means (SP) Sixty Day IL - Elbow. S. Hentges (RP) Sixty Day IL - Shoulder.
Notable Quotes
“We did a lot of trading with Cleveland in the offseason. They’re familiar with the group and have some good insight for us. They did some pretty cool things for [the Guardians].” - John Schneider after his team’s win against the Guardians in their game on Tuesday.
“It’s huge, what Lane did tonight. Any time our guys are getting multiple hits, they’re hitting multiple balls hard and they’re working walks.” - Stephen Vogt after his team’s loss against the Blue Jays in their game on Tuesday.
Starting Lineups
Toronto Blue Jays
Bo Bichette (R) SS
Ernie Clement (R) 3B
Vladimir Guerrero Jr. (R) 1B
Alejandro Kirk (R) C
George Springer (R) DH
Davis Schneider (R) LF
Jonatan Clase (S) RF
Myles Straw (R) CF
Andrés Giménez (L) 2B
Cleveland Guardians
Steven Kwan (L) LF
Lane Thomas (R) CF
José Ramírez (S) 3B
David Fry (R) DH
Carlos Santana (S) 1B
Gabriel Arias (R) SS
Angel Martínez (S) 2B
Johnathan Rodríguez (R) RF
Austin Hedges (R) C
Statistical Leaders
Toronto Blue Jays
Batting Average: Tyler Heineman (.394)
Hits: Bo Bichette (92)
Home Runs: Bo Bichette (11)
RBI: Bo Bichette (48)
Stolen Bases: Andrés Giménez (9)
Wins: Chris Bassitt (7)
Saves: Jeff Hoffman (17)
ERA: Justin Bruihl (0.00)
Cleveland Guardians
Batting Average: José Ramírez (.317)
Hits: José Ramírez (90)
Home Runs: José Ramírez (13)
RBI: Carlos Santana (37)
Stolen Bases: José Ramírez (20)
Wins: Gavin Williams (5)
Saves: Emmanuel Clase (18)
ERA: Nic Enright (2.25)
Managers:
Toronto Blue Jays: John Schneider (4th season)
Cleveland Guardians: Stephen Vogt (2nd season)