Texas Tech Red Raiders vs Iowa State Cyclones Prediction, Picks and Game Preview - 02/28/2026

Game Time: 4:00 pm ET, Saturday, February 28, 2026

Venue:  Hilton Coliseum, Ames, IA

Where to Watch:  CBS

DraftKings:  Point Spread:  TTU +9.5, ISU -9.5; Over/Under:  145.5 points

Bet365:  Point Spread:  TTU +9.5, ISU -9.5; Over/Under:  145.5 points

BetMGM:  Point Spread:  TTU +9.5, ISU -9.5; Over/Under:  145.5 points

Texas Tech Red Raiders:  21-7 (11-4) (5th place, Big 12)

Iowa State Cyclones:  24-4 (11-4) (3rd place, Big 12)

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Texas Tech Red Raiders:  4-1  last 5

Iowa State Cyclones:  3-2  last 5

Texas Tech is entering this game with a 21-7 record overall, an 11-4 record in conference games, and they are 4-4 in their road games this season where they will be in this game. They are coming off a win against the Cincinnati Bearcats in their last game. Christian Anderson led the team in points in that game with 31 while LeJuan Watts was next on the team with 13. Christian Anderson led the team in assists with 7 in that game while Christian Anderson led the team in rebounds with 11. They were 51.9% from the field, 40% from 3-point range, and 80% from the free throw line with their shooting in that game. Their offense is averaging 82 PPG and their defense is allowing their opponents to average 72.2 PPG against them. Texas Tech has an ATS record of 15-13 this season and their O/U record is 13-15.

Iowa State is entering this game with a 24-4 record overall, an 11-4 conference record, and they are 15-0 in their home games this season where they will be in this game. They are coming off a win against the Utah Utes in their last game. Joshua Jefferson led the team in points in that game with 21 while Milan Momcilovic was next on the team with 14. Tamin Lipsey led the team in assists with 5 in that game while Joshua Jefferson led the team in rebounds with 6. They were 47.5% from the field, 30.4% from 3-point range, and 66.7% from the free throw line with their shooting in that game. Their offense is averaging 82.8 PPG and their defense is allowing their opponents to average 64.9 PPG against them. Iowa State has an ATS record of 16-11-1 this season and their O/U record is 12-16.

The current betting odds have Iowa State listed as a 9.5 point favorite in this game according to Draftkings Sportsbook. Iowa State has looked really good in their games this season with their 24-4 record overall and their 11-4 conference record which has them right near the top of the Big 12. They have looked great on their home court too with their 15-0 home record this season. Meanwhile, Texas Tech has looked really good in their games this season with their 21-7 record overall and their 11-4 conference record which has them right near the top of the Big 12. They haven't been a great road team though with their 4-4 road record this year. Texas Tech has looked good lately as they are 4-1 in their last 5 games and coming off a double digit win over Cincinnati in their last one. They have looked like one of the best teams in the nation all season and were even looking like a contender at one point, but they are no longer one with the injury to Toppin. They have managed to stay afloat without him as they still have a ton of talent, but now they are getting a real test on the road and they did lose their last road game to a terrible Arizona State team. Iowa State is off a big road win over Utah in their last one and they have had their own trouble lately as they are 3-2 in their last 5 games, but both losses were in road games where they haven't looked as good. They are undefeated at home though and they have been rolling over opponents all year with a majority of their home wins coming by double digits. They have beaten some really good teams by double digits this season too, so they can definitely take advantage of a struggling road team in Texas Tech who is missing their best player. The best way to place a bet here is on Iowa State to cover the spread in this game. 

Texas Tech Iowa State Prediction:  Our NCAAB Pick for Saturday, February 28, 2026 (4:00 pm ET start time) is Iowa State 86 Texas Tech 75.

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Texas Tech Red Raiders: 6-11 ATS on the road when the total is 140 to 149.5. 18-24 1H ATS off a home win. 27-15 OVER when the total is 140 to 149.5. 33-21 OVER versus very good teams - outscoring their opponents by 8+ points/game.

Iowa State Cyclones: 30-17 ATS as a home favorite or pick. 25-14 ATS off a win against a conference rival. 28-15 ATS when playing against a good team (Win Pct. 60% to 80%). 29-17 OVER after a win by 15 points or more.

Texas Tech Red Raiders:  J. Toppin (F) Out - Knee. L. Hoover (F) Out - Redshirt.

Iowa State Cyclones:  X. Mitchell (F) Questionable - Undisclosed. M. Williams (G) Out - Hip.

“The guys' fight is right and their willingness to do what we're asking them to do is right. We just need more time and experience defensively. I’ve challenged those guards to go rebound way more because JT would gobble up a bunch, and now we’re going to have to do it more as a team than ever.” - Grant McCasland on his plan with JT Toppin out due to injury.

“Yeah, no, it was great to see him out there and get that opportunity. Blake has been dealing with some headaches and things and wasn't able to practice these last couple days. So, we just felt like it made more sense to go with Dom that way. Blake didn't feel any pressure that he needed to play or whatever. And I thought Pleta did a great job. And I'll say this, Blake Buchanan had one of his best games. I thought his energy out there defensively and attacking offensively. I just, I thought both guys played really well.” - T.J. Otzelberger on the lineup change in his team’s win against Utah.

C. Anderson 

D. Atwell 

J. Petty 

J. Toppin 

L. Watts

B. Buchanan 

J. Jefferson 

T. Lipsey 

M. Momcilovic 

K. Toure

PPG: JT Toppin (21.8)

APG: Christian Anderson (7.7)

Reb/G: JT Toppin (10.8)

PPG: Milan Momcilovic (17.4)

APG: Joshua Jefferson (5.2)

Reb/G: Joshua Jefferson (7.5)

Coaches:

Texas Tech Red Raiders: Grant McCasland (3rd season)

Iowa State Cyclones: T.J. Otzelberger (5th season)