by Rod Pearson
Thursday, Dec 11, 2025
Game Time: 4:25 pm ET, Sunday, December 14, 2025
Venue: Levi's Stadium, Santa Clara, CA
Where to Watch: FOX
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Titans +12.5, 49ers -12.5; Over/Under: 44.5 points
Bet365: Point Spread: Titans +12.5, 49ers -12.5; Over/Under: 44.5 points
BetMGM: Point Spread: Titans +12.5, 49ers -12.5; Over/Under: 44.5 points
Season Record
Tennessee Titans: 2-11 (4th place, AFC South)
San Francisco 49ers: 9-4 (3rd place, NFC West)
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Recent Form
Tennessee Titans: won their last game on the road against the Cleveland Browns 31-29.
San Francisco 49ers: won their last game on the road against the Cleveland Browns 26-8.
Tennessee Titans vs San Francisco 49ers Preview and Analysis
The Titans are entering this game with a 2-11 record overall and they have a 0-5 record in their divisional games too. They are 0-7 in their home games, 2-4 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Cleveland Browns 31-29. Cameron Ward was the starting QB and he completed 14/28 passes for 117 passing yards, 2 touchdowns, and 1 interception. Tony Pollard led the team in rushing yards with 161 and 2 TDs. Tyjae Spears led the receivers with 28 receiving yards on 2 receptions. Cedric Gray led the defense in that game with 7 solo tackles and 3 assisted tackles while Jeffery Simmons led the defense in sacks with 1.5. Xavier Woods came away with the only interception for them in that one.
The 49ers are entering this game with a 9-4 record overall and they have a 4-1 record in their divisional games too. They are 3-2 in their home games, 6-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the Cleveland Browns 26-8. Brock Purdy was the starting QB and he completed 16/29 passes for 168 passing yards, 1 touchdown, and 0 interceptions. Christian McCaffrey led the team in rushing yards with 53 and 1 TD. George Kittle led the receivers with 67 receiving yards on 4 receptions. Clelin Ferrell led the defense in that game with 6 solo tackles and 3 assisted tackles while Clelin Ferrell led the defense in sacks with 2. No one on the defense came away with an interception for them in that one.
Titans vs 49ers Prediction
The current betting odds have the 49ers listed as a 12.5 point favorite in this game according to Draftkings Sportsbook. The 49ers have looked really good in their games this season with their 9-4 record overall, but that record has them right near the bottom of the NFC West in a competitive division. They have looked good on their home field too with their 3-2 home record this year. Meanwhile, the Titans have looked terrible in their games this season with their 2-11 record overall which has them right at the bottom of the AFC South with one of the worst records in the entire NFL. They have been a bad road team too with their 2-4 road record this year. The Titans are off a 31-29 win over the Browns in their last one and their offense finally looked great against a good defense, but they have still been one of the worst teams in the NFL this year and don't have a ton of talent. They have been blown out in a lot of their games and this isn't a great situation for them. The 49ers are off a 26-8 win over the Browns in their last one, but they are also coming out of their bye week and have had extra time to prepare. They still need to win this game too since they are 3rd in their own division and fighting in a very competitive Wild Card race. The 49ers have a lot more talent and they have been starting to roll in their games lately, look for them to come out of their bye week strong and keep pace in a competitive division. The best way to place a bet here is on the 49ers to cover the spread in this game.
Titans 49ers Prediction: Our NFL Pick for Sunday, December 14, 2025 (4:25 pm ET start time) is 49ers 27 Titans 9.
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NFL Betting Trends
Tennessee Titans: 15-31 ATS in all games. 7-15 ATS as a road underdog. 0-7 ATS off an upset win as an underdog. 6-15 ATS when playing against a team with a winning record. 6-1 OVER as a road underdog of 7.5 to 14 points. 8-2 OVER when playing against a good team (Win Pct. 60% to 75%).
San Francisco 49ers: 4-1 ATS vs. poor passing teams averaging 175 or less passing yards/game. 4-0 ATS vs. poor teams - outscored by 6+ points per game on the season. 4-1 ATS in the second half of the season. 22-14 OVER in all games where the total is between 42.5 and 49 points. 5-1 OVER vs. poor passing teams averaging 5.7 or less passing yards/att.
Key Injuries
Tennessee Titans: K. Zeitler (OG) Injured - NIR - Rest. L. Cushenberry III (C) Injured - Foot. T. Pollard (RB) Injured - NIR - Rest. J. Simmons (DL) Injured - NIR - Rest. D. Moore Jr. (OT) Injured - Neck. S. Tuttle (DL) Injured - Concussion. J. Armour-Davis (CB) Injured - Achilles. C. Okonkwo (TE) Injured - NIR - Rest. J. Williams Sr. (LB) Injured - Illness. C. Ravenell (DL) Injured - Toe.
San Francisco 49ers: K. Juszczyk (FB) Injured - Ribs. T. Williams (OT) Injured - NIR-Rest. C. McCaffrey (RB) Injured - NIR-Rest. E. Pineiro (K) Injured - Hamstring. K. Givens (DL) Injured - NIR-Personal. S. Okuayinonu (DL) Injured - Ankle. T. Bethune (LB) Injured - Ankle. K. Rourke (QB) Injured - Knee. N. Martin (LB) Injured - Concussion.
Notable Quotes
“This is complementary football. Big plays in all three phases.” - Mike McCoy after his team’s win against the Browns in their last game.
“I thought it was pretty good. He had pressure on him to do it. He couldn't let his teammates down.” - Kyle Shanahan after his team’s win against the Browns in their last game.
Starting Lineups
Tennessee Titans
WR Ayomanor, Elic
WR Jefferson, Van
WR Dike, Chimere
TE Okonkwo, Chig
QB Ward, Cam
RB Pollard, Tony
San Francisco 49ers
WR Pearsall, Ricky
WR Jennings, Jauan
WR Robinson, Demarcus
TE Kittle, George
QB Purdy, Brock
RB McCaffrey, Christian
FB Juszczyk, Kyle
Statistical Leaders
Tennessee Titans
Passing: Cam Ward (2,468)
Rushing: Tony Pollard (743)
Receiving: Chig Okonkwo (426)
Touchdowns: Tony Pollard (4)
San Francisco 49ers
Passing: Mac Jones (2,151)
Rushing: Christian McCaffrey (849)
Receiving: Christian McCaffrey (806)
Touchdowns: Christian McCaffrey (13)
Coaches:
Tennessee Titans: Mike McCoy (Interim)
San Francisco 49ers: Kyle Shanahan (9th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
