Tennessee Titans vs New York Giants Prediction, Preview and Odds - 09/27/2026

Game Time: 1:00 pm ET, Sunday, September 27, 2026

Venue:  MetLife Stadium, East Rutherford, NJ

Where to Watch:  CBS

DraftKings:  Point Spread:  Titans +2.5, Giants -2.5; Over/Under:  38.5 points

Bet365:  Point Spread:  Titans +2.5, Giants -2.5; Over/Under:  38.5 points

BetMGM:  Point Spread:  Titans +2.5, Giants -2.5; Over/Under:  38.5 points

Tennessee Titans:  0-2 (2nd place, AFC South)

New York Giants:  1-1 (2nd place, NFC East)

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Tennessee Titans:  lost their last game at home against the Philadelphia Eagles 24-20.

New York Giants:  lost their last game on the road against the Los Angeles Rams 28-6.

The Titans are entering this game with a 0-2 record overall and they have a 0-0 record in their divisional games too. They are 0-2 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the Philadelphia Eagles 24-20. Cameron Ward was the starting QB and he completed 13/20 passes for 183 passing yards, 0 touchdowns, and 0 interceptions. Tony Pollard led the team in rushing yards with 64. Elic Ayomanor led the receivers with 69 receiving yards on 2 receptions. Anthony Hill Jr. led the defense in that game with 10 solo tackles while Jeffery Simmons, John Franklin-Myers, and Jacob Martin each led the defense in sacks with 1. Marcus Harris and Amani Hooker each came away with 1 interception for them in that one.

 

 

 

The Giants are entering this game with a 1-1 record overall and they have a 1-0 record in their divisional games too. They are 1-0 in their home games, 0-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Los Angeles Rams 28-6. Jaxson Dart was the starting QB and he completed 3/5 passes for 20 passing yards before leaving injured and getting replaced by Jameis Winston who completed 11/27 passes for 111 yards, 0 touchdowns, and 1 interception. Cameron Skattebo led the team in rushing yards with 36. Darnell Mooney led the receivers with 48 receiving yards on 2 receptions. Tyler Nubin and Jevon Holland each led the defense in that game with 8 solo tackles while Abdul Carter led the defense in sacks with 1. Jevon Holland came away with the only interception for them in that one.

The current betting odds have the Titans listed as a 2.5 point underdog in this game according to Draftkings Sportsbook. The Titans have looked terrible in their games this season with their 0-2 record overall so far. They haven't played any road games either and will be playing their 1st road game of the season here. Meanwhile, the Giants haven't looked great in their games this season with their 1-1 record overall so far. They have looked better on their home field though with their 1-0 home record this season. The Giants had a ton of promise entering the season with their new head coach and they came out really nice in week 1. They picked up an upset win over the Cowboys and looked like they were going to do something this year, but all of that went down the drain last week. Now they are coming off a 28-6 loss to the Rams in their last one and they lost Dart for the rest of the season. Winston looked terrible running the offense in his absence too. The Titans were one of the worst teams in the NFL last season and they also entered this year with a new head coach. They looked just as bad as last year in their week 1 loss to the Jets 23-10, but they did look a lot better last week. They are coming off a 24-20 loss at home against a solid Eagles team and they even had a chance to win that game outright with the Eagles finding the winning TD in the dying seconds of the game. It is still a loss in the end, but the way they improved is encouraging and they are going to bring their best effort here with a chance to take advantage of a team missing their starting QB. Look for the Titans to take advantage of a bad situation for the Giants and pick up their 1st win of the year. The best way to place a bet here is on the Titans to cover the spread in this game. 

Titans Giants Prediction:  Our NFL Pick for Sunday, September 27, 2026 (1:00 pm ET start time) is Titans 20 Giants 17.

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Tennessee Titans: 21-13 ATS against NFC East division opponents. 68-47 ATS in non-conference games. 22-14 OVER in all games. 12-5 OVER as a road underdog. 13-3 OVER after playing a game at home.

New York Giants: 13-21 ATS in all games. 3-8 ATS in games where the line is +3 to -3. 2-6 ATS after a loss by 14 or more points. 9-3 OVER off a road loss. 10-5 OVER after playing their last game on the road.

Tennessee Titans:  M. Harris (CB) Injured - Shoulder. M. Robinson (CB) Injured - Groin. D. Bellinger (TE) Injured - Illness. F. Carmona Jr. (OG) Injured - Shoulder. C. Flott (CB) Injured - Quad. T. Pollard (RB) Injured - Ankle. T. Spears (RB) Injured - Ankle. J. Williams Sr. (LB) Injured - Elbow. S. Thomas (DL) Injured - Knee.

New York Giants:  S. Harris (DL) Injured - Toe. J. Eluemunor (OG) Injured - Thigh. B. Burns (LB) Injured - Ankle. A. Thomas (OT) Injured - Groin. G. Newsome II (CB) Injured - Rib. M. McFadden (LB) Injured - Neck. D. Banks (CB) Injured - Calf. N. Jones (CB) Injured - Shoulder. M. Nabers (WR) Injured - Shoulder. T. Nubin (S) Injured - Calf. J. Dart (QB) Injured - Knee. F. Mauigoa (OG) Injured - Neck.

“They executed better in critical moments.” - Robert Saleh after his team’s loss against the Eagles in their last game. 

“It's tough to come in, (but Winston) executed and he operated well. But as a group, as a team, we just didn't do what we needed to do to even have a chance to win the game. We didn't play up to that level across the board.” - John Harbaugh after his team’s loss against the LA Rams in their last game. 

WR Ridley, Calvin

WR Tate, Carnell

WR Robinson, Wan'Dale

TE Helm, Gunnar

QB Ward, Cam

RB Pollard, Tony

WR Nabers, Malik

WR Fields, Malachi

WR Mooney, Darnell

TE Likely, Isaiah

QB Winston, Jameis

RB Skattebo, Cam

FB Ricard, Patrick

Passing: Cam Ward (323)

Rushing: Tony Pollard (99)

Receiving: Elic Ayomanor (80)

Touchdowns: Cam Ward (2)

Passing: Jaxson Dart (250)

Rushing: Cam Skattebo (117)

Receiving: Isaiah Likely (111)

Touchdowns: Isaiah Likely (2)

Coaches:

Tennessee Titans: Robert Saleh (1st season)

New York Giants: John Harbaugh (1st season)