by Rod Pearson
Friday, Oct 16, 2026
Game Time: 1:00 pm ET, Sunday, October 18, 2026
Venue: Lucas Oil Stadium, Indianapolis, IN
Where to Watch: FOX
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Titans +7, Colts -7; Over/Under: 44.5 points
Bet365: Point Spread: Titans +7, Colts -7; Over/Under: 44.5 points
BetMGM: Point Spread: Titans +7, Colts -7; Over/Under: 44.5 points
Season Record
Tennessee Titans: 0-5 (4th place, AFC South)
Indianapolis Colts: 2-3 (2nd place, AFC South)
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Tennessee Titans: lost their last game at home against the Houston Texans 26-3.
Indianapolis Colts: lost their last game on the road against the Pittsburgh Steelers 34-22.
Tennessee Titans vs Indianapolis Colts Preview and Analysis
The Titans are entering this game with a 0-5 record overall and they have a 0-1 record in their divisional games too. They are 0-3 in their home games, 0-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the Houston Texans 26-3. Cameron Ward was the starting QB and he completed 23/36 passes for 170 passing yards, 0 touchdowns, and 1 interception. Tony Pollard led the team in rushing yards with 52. Wan'Dale Robinson led the receivers with 53 receiving yards on 6 receptions. Tony Adams led the defense in that game with 9 solo tackles while Jacob Martin led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.
The Colts are entering this game with a 2-3 record overall and they have a 1-0 record in their divisional games too. They are 1-1 in their home games, 0-2 in their road games, and they are also 1-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Pittsburgh Steelers 34-22. Daniel Jones was the starting QB and he completed 24/44 passes for 267 passing yards, 0 touchdowns, and 0 interceptions. Jonathan Taylor led the team in rushing yards with 45. Tyler Warren led the receivers with 83 receiving yards on 7 receptions. Akeem Davis-Gaither led the defense in that game with 7 solo tackles while DeForest Buckner led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.
Titans vs Colts Prediction
The current betting odds have the Colts listed as a 7 point favorite in this game according to Draftkings Sportsbook. The Colts haven't looked great in their games this season with their 2-3 record overall, but that record has them right near the top of the AFC South. They haven't looked great on their home field either with their 1-1 home record this season. Meanwhile, the Titans have looked terrible in their games this season with their 0-5 record overall which has them right at the bottom of the AFC South. They haven't been a good road team either with their 0-2 road record this year. The Titans are coming off a 26-3 loss to the Texans in their last one and even with a new head coach this season they still look like the same old Titans. Cam Ward has had a lot of trouble in this offense all year and they look like they are going to be one of the worst teams in the NFL again. The Colts are coming off a 34-22 loss to the Steelers in their last one, but that wasn't a great situation for them coming back from London. They have been really up and down this season, but they do have a lot of talent that could make them a playoff team. They have a great rushing attack with one of the best RB's in the NFL and their defense has looked a lot better lately too. The Titans aren't going to be much of a challenge on offense and the Colts should be able to pull away throughout this game as they look to bounce back at home. The best way to place a bet here is on the Colts to cover the spread in this game.
Titans Colts Prediction: Our NFL Pick for Sunday, October 18, 2026 (1:00 pm ET start time) is Colts 27 Titans 17.
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NFL Betting Trends
Tennessee Titans: 11-28 ATS in all games. 7-15 ATS as an underdog of 3.5 to 9.5 points. 2-11 ATS versus division opponents. 2-9 ATS vs. good offensive teams - scoring 24 or more points/game. 9-4 OVER in all games where the total is between 42.5 and 49 points. 13-2 OVER after scoring 14 points or less last game.
Indianapolis Colts: 6-3 ATS as a home favorite. 16-10 ATS in all games where the total is between 42.5 and 49 points. 8-4 ATS when playing against a team with a losing record. 9-4 ATS versus division opponents. 17-10 OVER against conference opponents. 9-4 OVER when playing against a team with a losing record.
Key Injuries
Tennessee Titans: J. Franklin-Myers (DL) Injured - NIR-Rest. A. Hooker (S) Injured - Concussion. T. Pollard (RB) Injured - NIR-Rest. C. Flott (CB) Injured - Chest. T. Spears (RB) Injured - Knee. J. Williams (CB) Injured - Pec. D. Martin-Robinson (TE) Injured - Hamstring. K. Winston Jr. (S) Injured - Quad. M. Harris (CB) Injured - Ankle.
Indianapolis Colts: G. Stewart (DL) Injured - Rest. J. Travis (OT) Injured - Ankle. C. Ward (CB) Injured - Rest. K. Allen (WR) Injured - Rest. J. Carlies (LB) Injured - Ribs. J. Downs (WR) Injured - Rest. A. Dulin (WR) Injured - Hamstring. D. Jones (QB) Injured - Ankle. W. Mallory (TE) Injured - Thumb. D. Slayton (WR) Injured - Knee. J. Taylor (RB) Injured - Rest.
Notable Quotes
“We’ve got a lot of work to do. One game is not going to define us. We’re going to continue to work. We’re going to continue to find ways to get better. This organization and team will have its day in the sun.” - Robert Saleh after his team’s loss against the Texans in their last game.
“We settled for way too many field goals today. Those points are huge. They’re four-point plays. Spence did a great job making the kicks, but we have to score touchdowns when we’re in the red zone.” - Shane Steichen after his team’s loss against the Steelers in their last game.
Starting Lineups
Tennessee Titans
WR Ayomanor, Elic
WR Tate, Carnell
WR Robinson, Wan'Dale
TE Helm, Gunnar
QB Ward, Cam
RB Pollard, Tony
Indianapolis Colts
WR Treadwell, Laquon
WR Allen, Keenan
WR Downs, Josh
TE Warren, Tyler
QB Jones, Daniel
RB Taylor, Jonathan
Statistical Leaders
Tennessee Titans
Passing: Cam Ward (896)
Rushing: Tony Pollard (273)
Receiving: Carnell Tate (274)
Touchdowns: Cam Ward (2)
Indianapolis Colts
Passing: Daniel Jones (1,021)
Rushing: Jonathan Taylor (398)
Receiving: Josh Downs (249)
Touchdowns: Jonathan Taylor (6)
Coaches:
Tennessee Titans: Robert Saleh (1st season)
Indianapolis Colts: Shane Steichen (4th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
