Tampa Bay Rays vs Toronto Blue Jays Prediction, Preview and Odds - 07/22/2026

Game Time: 7:07 pm ET, Wednesday, July 22, 2026

Venue:  Rogers Centre, Toronto, ON

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Rays -110, Blue Jays -110; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Rays -110, Blue Jays -110; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Rays -110, Blue Jays -110; Over/Under:  8.5 runs

Tampa Bay Rays:  57-42 (1st place, AL East)

Toronto Blue Jays:  46-54 (5th place, AL East)

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Tampa Bay Rays:  4-6 last 10

Toronto Blue Jays:  4-6 last 10

The Rays are entering this series off a loss and got swept in their 4-game series against the Boston Red Sox 4-0 in their last series. They enter this game with a 57-42 record overall and have a road record of 22-27. This is the 3rd game of a 4-game series with the Blue Jays on Wednesday with the 2nd game still to be played on Tuesday. The Rays won the series opener on Monday. Their offense ranks 10th in the MLB with a .734 OPS. Drew Rasmussen is their starting pitcher on Tuesday while Griffin Jax is making his start in this game on Wednesday. He is 5-7 with a 4.08 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season appearance, he allowed 7 ER, 1 HR, and 1 BB with 6 SO on 8 hits through 5 IP against the Boston Red Sox.

The Blue Jays are entering this series off a loss and lost their 3-game series against the Chicago White Sox 2-1 in their last series. They enter this game with a 46-54 record overall and have a home record of 25-28. This is the 3rd game of a 4-game series with the Rays on Wednesday with the 2nd game of this series still to be played on Tuesday. The Blue Jays lost the 1st game of this series on Monday. Their offense ranks 28th in the MLB with a .684 OPS. Kevin Gausman is their starting pitcher on Tuesday while Braydon Fisher is making his start in this game on Wednesday. He is 3-3 with a 3.65 ERA this season. His team lost their last 5 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 1 earned run, 0 homers, and 0 walks with 1 strikeout on 2 hits through 1 inning pitched against the Tampa Bay Rays.

The current betting odds have the Rays listed as a pick ‘em in this game according to Draftkings Sportsbook. The Rays have looked great in their games this season with their 57-42 record overall which has them right at the top of the AL East with one of the best records in MLB. They haven't been a great road team though with their 22-27 road record this year. Meanwhile, the Blue Jays haven't looked good in their games this season with their 46-54 record overall which has them right at the bottom of the AL East. They haven't looked great in their own ballpark either with their 25-28 home record this season. The Rays haven't looked great lately, going 4-6 in their last 10 games and getting swept by the Red Sox in their last series, but this is a great opportunity for them to gain some ground back in the division. The Blue Jays are also 4-6 in their last 10 games and they have been entering a big slump lately, sliding down to last in their own division. Their offense has taken a big step back from where it was last season and their pitching has been terrible all season, now dealing with some injuries too. They aren't going to have the best arms going in this game and the Rays haven't had a bad offense this season. The Rays are going with Jax in this one and he hasn't looked great this season. He is 5-7 with a 4.08 ERA and lately he hasn't looked great. He gave up 7 earned runs in his last start and the team has lost 2 of their last 3 games now with him starting, but he will be looking to bounce back with a better performance against this struggling Blue Jays offense. The Rays also have a big edge here with the stronger bullpen to help them out, so look for the Rays to get themselves back on track against a slumping Blue Jays team. The best way to place a bet here is on the Rays to win this game. 

Rays Blue Jays Prediction:  Our MLB Pick for Wednesday, July 22, 2026 (7:07 pm ET start time) is Rays 6 Blue Jays 4.

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Tampa Bay Rays: 57-42 (+11.3 units) on the moneyline in all games. 28-14 (+10.8 units) on the moneyline when playing against a bad team (Win Pct. 38% to 46%). 20-12 (+9.3 units) on the moneyline against division opponents. 25-19 OVER vs. AL teams scoring 4.4 or less runs/game on the season.

Toronto Blue Jays: 46-54 (-16.3 units) on the moneyline in all games. 25-28 (-11.3 units) on the moneyline in home games. 27-35 (-13.6 units) on the moneyline vs. an AL team with an on base percentage .330 or worse. 23-17 OVER when playing against a team with a winning record.

Tampa Bay Rays:  S. Matz (SP) Fifteen Day IL - Ankle. J. Heasley (RP) Sixty Day IL - Elbow. G. Lux (LF) Sixty Day IL - Shoulder. J. Scholtens (SP) Fifteen Day IL - Wrist. J. Fraley (RF) Ten Day IL - Groin. R. Pepiot (SP) Sixty Day IL - Hip. E. Uceta (RP) Sixty Day IL - Shoulder. S. Wilson (RP) Sixty Day IL - Back. M. Rodriguez (RP) Sixty Day IL - Elbow.

Toronto Blue Jays:  J. Sanchez (RF) Ten Day IL - Ankle. M. Scherzer (SP) Fifteen Day IL - Back. J. Mantiply (RP) Sixty Day IL - Knee. L. Sosa (2B) Ten Day IL - Wrist. J. Berrios (SP) Sixty Day IL - Elbow. A. Barger (RF) Ten Day IL - Elbow. C. Ponce (SP) Sixty Day IL - Knee. A. Santander (RF) Sixty Day IL - Shoulder. Y. Garcia (RP) Sixty Day IL - Elbow. B. Francis (SP) Sixty Day IL - Elbow.

“He’s been huge for us all season long. We needed a really good start. He gave us one.” - Kevin Cash on Nick Martinez after his team’s win against the Blue Jays in their game on Monday. 

“I don’t know what it’s like to wake up and be Vlad, and the expectations and pressure that comes with it. Yeah, he wants to be the guy. He’s here for a reason, and we signed him for a reason. He’s frustrated like we’re frustrated. I’ve got no problem with him showing it.” - John Schneider after his team’s loss against the Rays in their game on Monday. 

Yandy Díaz (R) DH

Jonathan Aranda (L) 1B

Junior Caminero (R) 3B

Cedric Mullins (L) CF

Chandler Simpson (L) LF

Victor Mesa Jr. (L) RF

Richie Palacios (L) 2B

Nick Fortes (R) C

Taylor Walls (S) SS

Ernie Clement (R) 2B

Nathan Lukes (L) RF

Vladimir Guerrero Jr. (R) 1B

George Springer (R) DH

Kazuma Okamoto (R) 3B

Daulton Varsho (L) CF

Alejandro Kirk (R) C

Andrés Giménez (L) SS

Myles Straw (R) LF

Batting Average:  Yandy Díaz (.311)

Hits:  Yandy Díaz (114)

Home Runs:  Junior Caminero (29)

RBI:  Jonathan Aranda (65)

Stolen Bases:  Chandler Simpson (24)

Wins:  Nick Martinez (9)

Saves:  Bryan Baker (25)

ERA:  Michael Grove (0.00)

Batting Average:  Ernie Clement (.298)

Hits:  Ernie Clement (111)

Home Runs:  Kazuma Okamoto (22)

RBI:  Kazuma Okamoto (62)

Stolen Bases:  Andrés Giménez (11)

Wins:  Dylan Cease (6)

Saves:  Louis Varland (20)

ERA:  Simeon Woods Richardson (0.00)

Managers:

Tampa Bay Rays: Kevin Cash (12th season)

Toronto Blue Jays: John Schneider (5th season)