Tampa Bay Rays vs Toronto Blue Jays Prediction, Preview and Odds - 07/21/2026

Game Time: 7:07 pm ET, Tuesday, July 21, 2026

Venue:  Rogers Centre, Toronto, ON

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Rays -115, Blue Jays -105; Over/Under:  7.5 runs

Bet365:  Moneyline odds:  Rays -115, Blue Jays -105; Over/Under:  7.5 runs

BetMGM:  Moneyline odds:  Rays -115, Blue Jays -105; Over/Under:  7.5 runs

Tampa Bay Rays:  56-42 (1st place, AL East)

Toronto Blue Jays:  46-53 (5th place, AL East)

Do not miss out on our expert handicapper analysis! Vegas Writer is on a HOT STREAK in MLB on a 73-55-3 MLB RUN for +$15,860 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Tampa Bay Rays:  4-6 last 10

Toronto Blue Jays:  4-6 last 10

The Rays are entering this series off a loss and got swept in their 4-game series against the Boston Red Sox 4-0 in their last series. They enter this game with a 56-42 record overall and have a road record of 21-27. This is the 2nd game of a 4-game series with the Blue Jays on Tuesday with the series opener still to be played on Monday. Their offense ranks 11th in the MLB with a .731 OPS. Nick Martinez is their starting pitcher on Monday while Drew Rasmussen is making his start in this game on Tuesday. He is 7-5 with a 3.26 ERA this season. His team lost their last 2 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 6 ER, 1 HR, and 0 BB with 2 SO on 7 hits through 2.1 IP against the New York Yankees.

The Blue Jays are entering this series off a loss and lost their 3-game series against the Chicago White Sox 2-1 in their last series. They enter this game with a 46-53 record overall and have a home record of 25-27. This is the 2nd game of a 4-game series with the Rays on Tuesday with the 1st game of this series still to be played on Monday. Their offense ranks 26th in the MLB with a .687 OPS. Dylan Cease is their starting pitcher on Monday while Kevin Gausman is making his start in this game on Tuesday. He is 4-8 with a 4.33 ERA this season. His team lost their last 6 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 3 earned runs, 0 homers, and 3 walks with 8 strikeouts on 4 hits through 6 innings pitched against the San Diego Padres.

The current betting odds have the Rays listed as a slight favorite in this game according to Draftkings Sportsbook. The Rays have looked great in their games this season with their 56-42 record overall which has them right at the top of the AL East with one of the best records in MLB. They haven't been a great road team though with their 21-27 road record this year. Meanwhile, the Blue Jays haven't looked good in their games this season with their 46-53 record overall which has them right at the bottom of the AL East. They haven't looked great in their own ballpark either with their 25-27 home record this season. The Rays are 4-6 in their last 10 games and they just got swept coming out of the All-Star break, but they will be looking to bounce back in this series and have consistently been the best team in the division all year. The Blue Jays are also 4-6 in their last 10 games which has slid them down to last place in their division with their offense being a big issue all season. Gausman is on the mound for the Blue Jays in this one and he hasn't looked great this year. He is 4-8 with a 4.33 ERA and the team has been having a ton of trouble with him lately. They have lost 6 games in a row now with him starting and he did give up 3 earned runs in his last start which has been a common theme for him. The Rays are going with Rasmussen in this one and he has looked good this season. He is 7-5 with a 3.26 ERA and he hasn't been giving up many runs all year. He did give up 6 earned runs in his last start and the team has lost 2 games in a row now with him starting, but that hasn't been a common theme for him this season and he will be looking to bounce back against an offense that has had trouble all season. The Rays are going to be motivated to bounce back after getting swept in 4 games by the red hot Red Sox, so look for the Rays to take advantage of this pitching matchup. The best way to place a bet here is on the Rays to win this game. 

Rays Blue Jays Prediction:  Our MLB Pick for Tuesday, July 21, 2026 (7:07 pm ET start time) is Rays 6 Blue Jays 3.

Don't miss our champion handicappers free picks, best bets, and expert baseball picks today.  And if you enjoyed this Tampa Bay Rays Toronto Blue Jays prediction, be sure to drop by every day for our daily MLB projections and previews.

Tampa Bay Rays: 56-42 (+9.7 units) on the moneyline in all games. 38-22 (+9 units) on the moneyline as a favorite of -110 or higher. 19-12 (+7.7 units) on the moneyline against division opponents. 24-15 OVER when the total is 7 to 7.5.

Toronto Blue Jays: 46-53 (-14.6 units) on the moneyline in all games. 25-27 (-9.6 units) on the moneyline in home games. 12-24 (-10.2 units) on the moneyline as an underdog of +100 to +150. 23-16 OVER vs. a team with a poor bullpen whose ERA is 4.20 or worse.

Tampa Bay Rays:  S. Matz (SP) Fifteen Day IL - Ankle. J. Heasley (RP) Sixty Day IL - Elbow. G. Lux (LF) Sixty Day IL - Shoulder. J. Scholtens (SP) Fifteen Day IL - Wrist. J. Fraley (RF) Ten Day IL - Groin. R. Pepiot (SP) Sixty Day IL - Hip. E. Uceta (RP) Sixty Day IL - Shoulder. S. Wilson (RP) Sixty Day IL - Back. M. Rodriguez (RP) Sixty Day IL - Elbow.

Toronto Blue Jays:  J. Sanchez (RF) Ten Day IL - Ankle. M. Scherzer (SP) Fifteen Day IL - Back. J. Mantiply (RP) Sixty Day IL - Knee. L. Sosa (2B) Ten Day IL - Wrist. J. Berrios (SP) Sixty Day IL - Elbow. A. Barger (RF) Ten Day IL - Elbow. C. Ponce (SP) Sixty Day IL - Knee. A. Santander (RF) Sixty Day IL - Shoulder. Y. Garcia (RP) Sixty Day IL - Elbow. B. Francis (SP) Sixty Day IL - Elbow.

"It's a talented team that kind of went through it early on in the season, and they've come out on the other side of it. We kind of caught the brunt of it." - Kevin Cash after his team’s loss against the Red Sox in their game on Sunday. 

“We’ve got to start winning. That’s just the bottom line. It doesn’t matter how you do it. If you win 1-0 or 10-9, you’ve got to start winning.” - John Schneider after his team’s loss against the White Sox in their game on Sunday. 

Yandy Díaz (R) DH

Jonathan Aranda (L) 1B

Junior Caminero (R) 3B

Cedric Mullins (L) CF

Chandler Simpson (L) LF

Victor Mesa Jr. (L) RF

Richie Palacios (L) 2B

Taylor Walls (S) SS

Hunter Feduccia (L) C

Ernie Clement (R) 2B

Nathan Lukes (L) RF

Vladimir Guerrero Jr. (R) DH

Kazuma Okamoto (R) 3B

Daulton Varsho (L) CF

Sean Keys (L) 1B

Brandon Valenzuela (S) C

Andrés Giménez (L) SS

Jonatan Clase (S) LF

Batting Average:  Yandy Díaz (.310)

Hits:  Yandy Díaz (112)

Home Runs:  Junior Caminero (29)

RBI:  Jonathan Aranda (64)

Stolen Bases:  Chandler Simpson (23)

Wins:  Shane McClanahan (8)

Saves:  Bryan Baker (25)

ERA:  Michael Grove (0.00)

Batting Average:  Ernie Clement (.295)

Hits:  Ernie Clement (109)

Home Runs:  Kazuma Okamoto (22)

RBI:  Kazuma Okamoto (62)

Stolen Bases:  Andrés Giménez (11)

Wins:  Dylan Cease (6)

Saves:  Louis Varland (20)

ERA:  Simeon Woods Richardson (0.00)

Managers:

Tampa Bay Rays: Kevin Cash (12th season)

Toronto Blue Jays: John Schneider (5th season)