by Rod Pearson
Friday, Nov 21, 2025
Game Time: 8:20 pm ET, Sunday, November 23, 2025
Venue: SoFi Stadium, Inglewood, CA
Where to Watch: NBC, Peacock
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Buccaneers +6.5, Rams -6.5; Over/Under: 49.5 points
Bet365: Point Spread: Buccaneers +7, Rams -7; Over/Under: 49.5 points
BetMGM: Point Spread: Buccaneers +6.5, Rams -6.5; Over/Under: 49.5 points
Season Record
Tampa Bay Buccaneers: 6-4 (1st place, NFC South)
Los Angeles Rams: 8-2 (1st place, NFC West)
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Recent Form
Tampa Bay Buccaneers: lost their last game on the road against the Buffalo Bills 44-32.
Los Angeles Rams: won their last game at home against the Seattle Seahawks 21-19.
Tampa Bay Buccaneers vs Los Angeles Rams Preview and Analysis
The Buccaneers are entering this game with a 6-4 record overall and they have a 2-0 record in their divisional games too. They are 2-2 in their home games, 4-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the Buffalo Bills 44-32. Baker Mayfield was the starting QB and he completed 16/28 passes for 173 passing yards, 1 touchdown, and 1 interception. Sean Tucker led the team in rushing yards with 106 and 2 TDs. Sterling Shepard led the receivers with 54 receiving yards on 4 receptions. Antoine Winfield Jr. led the defense in that game with 4 solo tackles and 2 assisted tackles while no one on the defense recorded a sack for them. Jacob Parrish and SirVocea Dennis each came away with 1 interception for them in that one.
The Rams are entering this game with an 8-2 record overall and they have a 2-1 record in their divisional games too. They are 4-1 in their home games, 3-1 in their road games, and they are also 1-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the Seattle Seahawks 21-19. Matthew Stafford was the starting QB and he completed 15/28 passes for 130 passing yards, 2 touchdowns, and 0 interceptions. Kyren Williams led the team in rushing yards with 91 and 1 TD. Puka Nacua led the receivers with 75 receiving yards on 7 receptions. Kamren Curl led the defense in that game with 9 solo tackles and 2 assisted tackles while no one on the defense recorded a sack for them. Kamren Kinchens led the defense in interceptions with 2 while Cobie Durant and Darious Williams each came away with 1 INT for them in that one.
Buccaneers vs Rams Prediction
The current betting odds have the Rams listed as a 6.5 point favorite in this game according to Draftkings Sportsbook. The Rams have looked great in their games this season with their 8-2 record overall which has them right at the top of the NFC West with one of the best records in the NFL. They are off a 21-19 win over the Seahawks in their last one and they have been rolling in their games lately with 5 wins in a row now. Meanwhile, the Buccaneers have looked good in their games this season with their 6-4 record overall which has them right at the top of the NFC South. They haven't looked as good lately though, losing 2 games in a row now with their injuries starting to take a toll on them. They are off a 44-32 loss to the Bills in their last one and now they are on the road for the 2nd straight week. Their defense has looked good this season, but they were terrible against the Bills and now they are facing an even better offense. The offense has looked great for the Buccaneers all season with Baker Mayfield finding ways in these games, but they are still very banged up and haven't had much of a run game all year. The Rams are the much healthier team right now and they have looked a lot better on both sides of the ball too. The best way to place a bet here is on the Rams to cover the spread in this game.
Buccaneers Rams Prediction: Our NFL Pick for Sunday, November 23, 2025 (8:20 pm ET start time) is Rams 27 Buccaneers 17.
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NFL Betting Trends
Tampa Bay Buccaneers: 5-9 ATS after scoring 30 points or more last game. 5-9 ATS versus good offensive teams - averaging 5.65 yards/play or more. 9-5 OVER as a road underdog of 7 points or less. 5-1 OVER when playing against a top-level team (Win Pct. > 75%).
Los Angeles Rams: 28-17 ATS in all games. 9-5 ATS as a favorite of 3.5 to 9.5 points. 8-4 ATS after a win by 6 or less points. 10-5 ATS vs. good offensive teams - scoring 24 or more points/game. 10-3 OVER off a home win. 6-3 OVER after a game with a turnover margin of +2 or better.
Key Injuries
Tampa Bay Buccaneers: H. Reddick (LB) Injured - Ankle. D. Feeney (OG) Injured - Illness. S. Shepard (WR) Injured - Shoulder. C. Godwin Jr. (WR) Injured - Fibula. B. Mayfield (QB) Injured - Illness. J. Dean (CB) Injured - Hip. C. McLaughlin (K) Injured - Personal. T. Wirfs (OT) Injured - Shoulder. B. Bredeson (OG) Injured - Hamstring. L. Goedeke (OT) Injured - Illness. M. Watts (LB) Injured - Hand. L. Hall (DL) Injured - Illness. B. Irving (RB) Injured - Shoulder. C. Braswell (LB) Injured - Foot. G. Barton (C) Injured - Illness. E. Egbuka (WR) Injured - Illness.
Los Angeles Rams: N. Landman (LB) Injured - Back. X. Smith (WR) Injured - Concussion. K. Turner (DL) Injured - Back. J. Wallace (CB) Injured - Knee.
Notable Quotes
“We’re in a good place mentally. Our fight is outstanding. Our execution needs to be cleaned up.” - Todd Bowles after his team’s loss against the Bills in their last game.
“We’re never going to apologize for being able to find ways to win.” - Sean McVay after his team’s win against the Seahawks in their last game.
Starting Lineups
Tampa Bay Buccaneers
WR Egbuka, Emeka
WR Johnson, Tez
WR Shepard, Sterling
TE Otton, Cade
QB Mayfield, Baker
RB White, Rachaad
Los Angeles Rams
WR Adams, Davante
WR Nacua, Puka
WR Whittington, Jordan
TE Parkinson, Colby
QB Stafford, Matthew
RB Williams, Kyren
Statistical Leaders
Tampa Bay Buccaneers
Passing: Baker Mayfield (2,365)
Rushing: Rachaad White (376)
Receiving: Emeka Egbuka (717)
Touchdowns: Emeka Egbuka (6)
Los Angeles Rams
Passing: Matthew Stafford (2,557)
Rushing: Kyren Williams (750)
Receiving: Puka Nacua (850)
Touchdowns: Davante Adams (10)
Coaches:
Tampa Bay Buccaneers: Todd Bowles (4th season)
Los Angeles Rams: Sean McVay (9th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
