St Louis Cardinals vs Cleveland Guardians Prediction, Preview and Odds - 06/27/2025

Game Time: 7:10 pm ET, Friday, June 27, 2025

Venue:  Progressive Field, Cleveland, OH

Where to Watch:  Apple TV+

DraftKings:  Moneyline odds:  Cardinals -132, Guardians +108; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Cardinals -130, Guardians +110; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Cardinals -130, Guardians +110; Over/Under:  8.5 runs

St Louis Cardinals:  44-37 (3rd place, NL Central)

Cleveland Guardians:  40-38 (2nd place, AL Central)

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St Louis Cardinals:  7-3 last 10

Cleveland Guardians:  5-5 last 10

The Cardinals won their 3-game series against the Cincinnati Reds 2-1. They enter this game with a 44-37 record overall and have a road record of 18-21. This is the series opener of a 3-game series with the Guardians on Friday with the series finale of their series against the Chicago Cubs still to be played on Thursday. The Cardinals won the series opener of that series on Monday, won the 2nd game on Tuesday, and lost the 3rd game on Wednesday. Their offense ranks 13th in the MLB with a .722 OPS. Andre Pallante is their starting pitcher on Thursday while Sonny Gray is making his start in this game on Friday. He is 7-2 with a 3.72 ERA this season. His team won 7 of their last 8 games this season with him making an appearance. In his last MLB regular season start, he allowed 1 ER, 0 HR, and 2 BB with 5 SO on 5 hits through 5 IP against the Cincinnati Reds.

The Guardians won their 3-game series against the Athletics 2-1. They enter this game with a 40-38 record overall and have a home record of 20-16. This is the 1st game of a 3-game series with the Cardinals on Friday with the 3rd game of their series against the Toronto Blue Jays still to be played on Thursday. The Guardians lost the 1st game of that series on Tuesday and won the 2nd game on Wednesday. Their offense ranks 25th in the MLB with a .675 OPS. Tanner Bibee is their starting pitcher on Thursday while Luis Ortiz is making his start in this game on Friday. He is 4-8 with a 4.30 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 0 earned runs, 0 homers, and 2 walks with 10 strikeouts on 2 hits through 6 innings pitched against the Athletics.

The current betting odds have the Cardinals listed as a slight favorite in this game according to Draftkings Sportsbook. The Cardinals have looked good in their games this season with their 44-37 record overall which has them right in the middle of the NL Central. They haven't been a great road team though with their 18-21 road record this season. Meanwhile, the Guardians have looked good in their games this season with their 40-38 record overall which has them right near the top of the AL Central. They have looked better in their own ballpark too with their 20-16 home record this season. The Guardians have been better at home this year, but the Cardinals do have the better offense and they are the hotter team coming into this game, going 7-3 in their last 10 games. They also have the better pitching matchup in this one and can take advantage of that. Gray is on the mound for the Cardinals in this one and he has looked great this season. He is 7-2 with a 3.72 ERA and hasn't been giving up many runs lately. He only gave up 1 earned run in his last start which has been a common theme for him, and the team has had a ton of success with him starting as they have won 7 of the last 8 games he started. Ortiz is on the mound for the Guardians in this one and he hasn't looked great this season. He is 4-8 with a 4.30 ERA and has been giving up quite a few runs lately. He didn't give up any runs in his last start, but that hasn't been a common theme for him and the team has still lost 2 of the last 3 games he started. The Cardinals have the edge with both their offense and the pitching matchup. The best way to place a bet here is on the Cardinals to win this game. 

Cardinals Guardians Prediction:  Our MLB Pick for Friday, June 27, 2025 (7:10 pm ET start time) is Cardinals 5 Guardians 2.

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St Louis Cardinals: 197-207 (-22.1 units) on the moneyline in all games. 90-92 (-38.9 units) on the moneyline as a favorite of -110 or higher. 142-148 (-12.4 units) on the moneyline against right-handed starters. 

Cleveland Guardians: 115-87 (+10 units) on the moneyline in home games. 113-102 (+10.4 units) on the moneyline when the money line is +125 to -125. 149-134 (+8.6 units) on the moneyline against right-handed starters.

St Louis Cardinals:  J. Walker (RF) Ten Day IL - Appendicitis. I. Herrera (C) Ten Day IL - Hamstring. Z. Thompson (RP) Sixty Day IL - Lat.

Cleveland Guardians:  A. Walters (RP) Sixty Day IL - Lat. B. Lively (SP) Sixty Day IL - Forearm. W. Brennan (RF) Ten Day IL - Forearm. P. Sewald (RP) Fifteen Day IL - Shoulder. S. Bieber (SP) Sixty Day IL - Elbow. E. Sabrowski (RP) Sixty Day IL - Elbow. T. Stephan (RP) Sixty Day IL - Elbow. J. Means (SP) Sixty Day IL - Elbow. S. Hentges (RP) Sixty Day IL - Shoulder.

“The confidence is pretty high with his first step [improving], and his overall determination to get better at that [right field] position has been awesome. He’s putting in the work, and it’s good to see him out there making some plays. And the range is improving, allowing him to get to some more plays. It does help us to not only be able to play him at first base and DH, but also being able to put him out there [in right field] from time to time. That frees up that DH spot.” - Oliver Marmol on Alec Burleson after his team’s loss against the Cubs in their game on Wednesday.

“Hosey up at the plate at any time is exciting. But with bases loaded, nobody out in a walk-off situation, [there’s] no one on the planet I'd rather have hitting -- especially [righty-hitting] Hosey.” - Stephen Vogt after his team’s win against the Blue Jays in their game on Wednesday.

Brendan Donovan (L) LF

Masyn Winn (R) SS

Alec Burleson (L) RF

Willson Contreras (R) 1B

Nolan Arenado (R) 3B

Thomas Saggese (R) 2B

Nolan Gorman (L) DH

Pedro Pagés (R) C

Garrett Hampson (R) CF

Steven Kwan (L) LF

Kyle Manzardo (L) 1B

José Ramírez (S) 3B

Carlos Santana (S) DH

Lane Thomas (R) RF

Daniel Schneemann (L) 2B

Bo Naylor (L) C

Gabriel Arias (R) SS

Angel Martínez (S) CF

Batting Average:  José Fermín (1.000)

Hits:  Brendan Donovan (87)

Home Runs:  Lars Nootbaar (11)

RBI:  Willson Contreras (50)

Stolen Bases:  Victor Scott (22)

Wins:  Sonny Gray (7)

Saves:  Ryan Helsley (15)

ERA:  Andre Granillo (1.35)

Batting Average:  José Ramírez (.318)

Hits:  José Ramírez (92)

Home Runs:  José Ramírez (13)

RBI:  José Ramírez (38)

Stolen Bases:  José Ramírez (20)

Wins:  Gavin Williams (5)

Saves:  Emmanuel Clase (18)

ERA:  Nic Enright (2.08)

Managers:

St Louis Cardinals: Oliver Marmol (4th season)

Cleveland Guardians: Stephen Vogt (2nd season)