by Rod Pearson
Wednesday, Oct 29, 2025
Game Time: 7:00 pm ET, Saturday, November 1, 2025
Venue: Vaught Hemingway Stadium, Oxford, MS
Where to Watch: ESPN
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: South Carolina +12.5, Ole Miss -12.5; Over/Under: 54.5 points
Bet365: Point Spread: South Carolina +12.5, Ole Miss -12.5; Over/Under: 54.5 points
BetMGM: Point Spread: South Carolina +12.5, Ole Miss -12.5; Over/Under: 54.5 points
Season Record
South Carolina Gamecocks: 3-5 (1-5) (13th place, SEC)
Mississippi Rebels: 7-1 (4-1) (3rd place, SEC)
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South Carolina Gamecocks: lost their last game at home against the Alabama Crimson Tide 29-22.
Mississippi Rebels: won their last game on the road against the Oklahoma Sooners 34-26.
South Carolina Gamecocks vs Mississippi Rebels Preview and Analysis
South Carolina is entering this game with a 3-5 record overall and they have a 1-5 record in their conference games too. They are 2-3 in their home games, 0-2 in their road games, and they are also 1-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against Alabama 29-22. LaNorris Sellers was the starting QB and he completed 18/32 passes for 222 passing yards, 1 touchdown, and 1 interception. LaNorris Sellers led the team in rushing yards with 67 and 1 TD. Nyck Harbor led the receivers with 54 receiving yards on 1 reception and 1 TD. Peyton Williams led the defense in that game with 6 solo tackles and 0 assisted tackles while Vicari Swain and Bryan Thomas Jr. each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.
Ole Miss is entering this game with a 7-1 record overall and they have a 4-1 record in their conference games too. They are 5-0 in their home games, 2-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against Oklahoma 34-26. Trinidad Chambliss was the starting QB and he completed 24/44 passes for 315 passing yards, 1 touchdown, and 0 interceptions. Kewan Lacy led the team in rushing yards with 78 and 2 TDs. Winston Watkins led the receivers with 111 receiving yards on 4 receptions. Kapena Gushiken led the defense in that game with 5 solo tackles and 1 assisted tackle while Princewill Umanmielen led the defense in sacks with 1.5. No one on the defense came away with an interception for them in that one.
South Carolina vs Mississippi Prediction
The current betting odds have Ole Miss listed as a 12.5 point favorite in this game according to Draftkings Sportsbook. Ole Miss has looked great in their games this season with their 7-1 record overall and their 4-1 conference record which has them right near the top of the SEC. They are off a 34-26 road win over Oklahoma in their last one and that win was a huge boost to their playoff hopes. They have a ton of momentum on their side now and they also have a great offense that has been putting up a ton of points in their games all season. Meanwhile, South Carolina hasn't looked good in their games this season with their 3-5 record overall and their 1-5 conference record which has them right near the bottom of the SEC. They were ranked entering the season, but they haven't lived up to the hype at all. They have been worse in their road games too with their 0-2 road record this season and their offense has been really up and down too. They were supposed to have a great defense this year, but they haven't looked great in a lot of their games against better offenses. Ole Miss has been rolling in their games lately and they have a real chance to make the CFP and even win the SEC Championship this year so they aren't going to slow down against a bad South Carolina team. The best way to place a bet here is on Ole Miss to cover the spread in this game.
South Carolina Mississippi Prediction: Our NCAAF Pick for Saturday, November 1, 2025 (7:00 pm ET start time) is Ole Miss 35 South Carolina 17.
Don't miss our champion handicappers free picks and expert football picks today. And if you enjoyed this South Carolina Gamecocks Mississippi Rebels prediction, be sure to drop by every day for our weekly NCAAF predictions and previews.
NCAAF Betting Trends
South Carolina Gamecocks: 8-3 ATS in road lined games. 8-4 ATS off a loss against a conference rival. 8-3 ATS vs. good offensive teams - scoring 31 or more points/game. 6-3 UNDER as a road underdog. 11-6 UNDER after playing a game at home.
Mississippi Rebels: 14-20 ATS after a 2 game road trip. 16-27 ATS when playing against a bad team (Win Pct. 25% to 40%). 3-11 ATS versus poor rushing teams - averaging 3.25 rushing yards/carry or less. 18-9 UNDER as a favorite. 5-0 UNDER when playing against a team with a losing record.
Key Injuries
South Carolina Gamecocks: C. Henry (OG) Questionable - Undisclosed.
Mississippi Rebels: None.
Notable Quotes
“It’s hard. As the coach, I feel like I’m letting a lot of people down. I know today let a lot of people down. I wish I had something to say to make it better.” - Shane Beamer after his team’s loss against Alabama in their last game.
“Same Georgia feeling. Crowd started coming alive. And then obviously, much different response by us. And I didn’t feel like they ever, you know, kind of freaked out. And they had each other’s back.” - Lane Kiffin after his team’s win against Oklahoma in their last game.
Starting Lineups
South Carolina Gamecocks
WR Harbor, Nyck
WR Jacobs, Vandrevius
WR Rowe Jr., Brian
TE Hunt, Brady
QB Sellers, LaNorris
RB Faison, Rahsul
Mississippi Rebels
WR Stribling, De'Zhaun
WR Wallace III, Harrison
WR Lee, Cayden
TE Wright, Dae'Quan
QB Chambliss, Trinidad
RB Lacy, Kewan
Statistical Leaders
South Carolina Gamecocks
Passing: LaNorris Sellers (1,356)
Rushing: Rahsul Faison (298)
Receiving: Vandrevius Jacobs (343)
Touchdowns: Rahsul Faison (3)
Mississippi Rebels
Passing: Trinidad Chambliss (1,864)
Rushing: Kewan Lacy (696)
Receiving: Harrison Wallace III (464)
Touchdowns: Kewan Lacy (12)
Coaches:
South Carolina Gamecocks: Shane Beamer (5th season)
Mississippi Rebels: Lane Kiffin (6th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
