Game Time: 1:00 pm ET, Sunday, November 23, 2025
Venue: Nissan Stadium, Nashville, TN
Where to Watch: FOX
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Seahawks -13.5, Titans +13.5; Over/Under: 40.5 points
Bet365: Point Spread: Seahawks -13, Titans +13; Over/Under: 40.5 points
BetMGM: Point Spread: Seahawks -13.5, Titans +13.5; Over/Under: 40.5 points
Season Record
Seattle Seahawks: 7-3 (2nd place, NFC West)
Tennessee Titans: 1-9 (4th place, AFC South)
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Seattle Seahawks: lost their last game on the road against the Los Angeles Rams 21-19.
Tennessee Titans: lost their last game at home against the Houston Texans 16-13.
Seattle Seahawks vs Tennessee Titans Preview and Analysis
The Seahawks are entering this game with a 7-3 record overall and they have a 2-2 record in their divisional games too. They are 3-2 in their home games, 4-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the Los Angeles Rams 21-19. Sam Darnold was the starting QB and he completed 29/44 passes for 279 passing yards, 0 touchdowns, and 4 interceptions. Kenneth Walker III led the team in rushing yards with 67 and 1 TD. Jaxon Smith-Njigba led the receivers with 105 receiving yards on 9 receptions. Ernest Jones IV led the defense in that game with 5 solo tackles and 1 assisted tackle while no one on the defense recorded a sack for them. No one on the defense came away with an interception for them in that one.
The Titans are entering this game with a 1-9 record overall and they have a 0-4 record in their divisional games too. They are 0-5 in their home games, 1-4 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Houston Texans 16-13. Cameron Ward was the starting QB and he completed 24/37 passes for 194 passing yards, 1 touchdown, and 0 interceptions. Cameron Ward led the team in rushing yards with 33. Chigoziem Okonkwo led the receivers with 56 receiving yards on 3 receptions. Darrell Baker Jr. led the defense in that game with 8 solo tackles and 3 assisted tackles while Arden Key led the defense in sacks with 1.5. No one on the defense came away with an interception for them in that one.
Seahawks vs Titans Prediction
The current betting odds have the Seahawks listed as a 13.5 point favorite in this game according to Draftkings Sportsbook. The Seahawks have looked really good in their games this season with their 7-3 record overall which has them right near the top of the NFC West. They have been rolling all season with one of the best defenses in the NFL and they have been a better road team too with their 4-1 road record. Meanwhile, the Titans have looked terrible in their games this season with their 1-9 record overall which has them right at the bottom of the AFC South with the worst record in the entire NFL. They haven't won a game at home with their 0-5 home record and they have been getting blown out in a lot of games. The offense hasn't looked good with Cam Ward struggling in his rookie season, and now they are missing a lot of key players in that offense. They are off a 16-13 loss to the Texans in their last one and had a chance to win, but they haven't had many of those close games this season. The Seahawks are off a 21-19 loss to the Rams in their last one and that was a big game for the division so they are going to be angry and looking to bounce back here. The offense was also terrible in that loss so they will be looking to have a better game on offense and won't take their foot off the gas. The best way to place a bet here is on the Seahawks to cover the spread in this game.
Seahawks Titans Prediction: Our NFL Pick for Sunday, November 23, 2025 (1:00 pm ET start time) is Seahawks 41 Titans 7.
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NFL Betting Trends
Seattle Seahawks: 14-6 ATS in road games. 6-1 ATS off a loss against a division rival. 9-4 ATS after playing a division game. 9-2 OVER in all games where the total is between 35.5 and 42 points.
Tennessee Titans: 13-30 ATS in all games. 9-20 ATS in all games where the total is between 35.5 and 42 points. 4-13 ATS after playing a game at home. 1-9 ATS vs. good offensive teams - scoring 24 or more points/game. 12-3 OVER after scoring 14 points or less last game.
Key Injuries
Seattle Seahawks: D. Lawrence (LB) Injured - NIR-Rest. L. Williams (DL) Injured - NIR-Rest. C. Bryant (S) Injured - Foot. C. White (WR) Injured - Abdomen. E. Jones IV (LB) Injured - Knee. M. Morris (DL) Injured - Knee. J. Smith-Njigba (WR) Injured - NIR-Rest. T. Knight (LB) Injured - Concussion. G. Zabel (OG) Injured - Knee. T. Horton (WR) Injured - Shin. R. Ouzts (FB) Injured - Elbow. N. Emmanwori (S) Injured - Hand.
Tennessee Titans: K. Zeitler (OG) Injured - Back. X. Woods (S) Injured - Hamstring. J. Ward (LB) Injured - NIR - Rest. D. Baker Jr. (CB) Injured - Knee. J. Bachie (LB) Injured - Ankle. J. Simmons (DL) Injured - Hamstring. C. Okonkwo (TE) Injured - Foot. T. Spears (RB) Injured - NIR - Rest. K. Brooks (CB) Injured - Concussion. E. Ayomanor (WR) Injured - Hamstring. K. Mullings (RB) Injured - Ankle. C. Dike (WR) Injured - Chest.
Notable Quotes
“We’re about 3 yards short from putting ourselves in a great position to go win, given all the things that happened throughout the game.” - Mike Macdonald after his team’s loss against the LA Rams in their last game.
“You just can’t beat yourself against a really good football team, and that’s what happened. The penalties kill you. It’s tough. It’s tough enough to play against a great defense like that, and then when you have just the penalties that you hurt yourself, it’s even harder.” - Mike McCoy after his team’s loss against the Texans in their last game.
Starting Lineups
Seattle Seahawks
WR Smith-Njigba, Jaxon
WR Shaheed, Rashid
WR Kupp, Cooper
TE Barner, AJ
QB Darnold, Sam
RB Walker III, Kenneth
FB Ouzts, Robbie
Tennessee Titans
WR Jefferson, Van
WR Kinsey, Mason
TE Okonkwo, Chig
QB Ward, Cam
RB Pollard, Tony
Statistical Leaders
Seattle Seahawks
Passing: Sam Darnold (2,541)
Rushing: Kenneth Walker III (606)
Receiving: Jaxon Smith-Njigba (1,146)
Touchdowns: Zach Charbonnet (6)
Tennessee Titans
Passing: Cam Ward (1,954)
Rushing: Tony Pollard (502)
Receiving: Chig Okonkwo (337)
Touchdowns: Elic Ayomanor (2)
Coaches:
Seattle Seahawks: Mike Macdonald (2nd season)
Tennessee Titans: Mike McCoy (Interim)