by Rod Pearson
Tuesday, Dec 30, 2025
Game Time: 8:00 pm ET, Saturday, January 3, 2026
Venue: Levi's Stadium, Santa Clara, CA
Where to Watch: ESPN, ABC
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Seahawks -1.5, 49ers +1.5; Over/Under: 49.5 points
Bet365: Point Spread: Seahawks -1.5, 49ers +1.5; Over/Under: 49.5 points
BetMGM: Point Spread: Seahawks -1.5, 49ers +1.5; Over/Under: 49.5 points
Season Record
Seattle Seahawks: 13-3 (1st place, NFC West)
San Francisco 49ers: 12-4 (2nd place, NFC West)
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Recent Form
Seattle Seahawks: won their last game on the road against the Carolina Panthers 27-10.
San Francisco 49ers: won their last game at home against the Chicago Bears 42-38.
Seattle Seahawks vs San Francisco 49ers Preview and Analysis
The Seahawks are entering this game with a 13-3 record overall and they have a 3-2 record in their divisional games too. They are 6-2 in their home games, 7-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Carolina Panthers 27-10. Sam Darnold was the starting QB and he completed 18/27 passes for 147 passing yards, 1 touchdown, and 1 interception. Zach Charbonnet led the team in rushing yards with 110 and 2 TDs. Jaxon Smith-Njigba led the receivers with 72 receiving yards on 9 receptions. Julian Love and Ty Okada each led the defense in that game with 5 solo tackles and 1 assisted tackle while DeMarcus Lawrence and Boye Mafe each led the defense in sacks with 1. Julian Love came away with the only interception for them in that one.
The 49ers are entering this game with a 12-4 record overall and they have a 4-1 record in their divisional games too. They are 5-2 in their home games, 7-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the Chicago Bears 42-38. Brock Purdy was the starting QB and he completed 24/33 passes for 303 passing yards, 3 touchdowns, and 1 interception. Christian McCaffrey led the team in rushing yards with 140 and 1 TD. Ricky Pearsall led the receivers with 85 receiving yards on 5 receptions. Tatum Bethune led the defense in that game with 7 solo tackles and 4 assisted tackles while no one on the defense recorded a sack for them. No one on the defense came away with an interception for them in that one.
Seahawks vs 49ers Prediction
The current betting odds have the Seahawks listed as a 1.5 point favorite in this game according to Draftkings Sportsbook. The Seahawks have looked great in their games this season with their 13-3 record overall which has them right at the top of the NFC West with one of the best records in the entire NFL. They have also been a great road team this year with their 7-1 road record. Meanwhile, the 49ers have looked really good in their games this season with their 12-4 record overall which has them right near the top of the NFC West. They have looked good on their home field too with their 5-2 home record this season. The 49ers are off a 42-38 win over the Bears in their last one and they still have everything in front of them here, playing for the NFC West and the number 1 seed in the NFC in this game. They have been rolling lately with 6 wins in a row now and their offense has been putting up a ton of points, but their defense has looked terrible and they barely escaped that game against the Bears last week. Their defense is going to be a big issue in the playoffs and the Seahawks are not only playing for the division and number 1 seed here, they are also playing for their revenge from a 17-13 loss at home to the 49ers to start the season. The Seahawks have come a long way from that game though, their offense looking a lot better lately and their defense being one of the best in the NFL. The Seahawks are going to take the number 1 seed in the NFC here and their defense will be a big reason why. The best way to place a bet here is on the Seahawks to cover the spread in this game.
Seahawks 49ers Prediction: Our NFL Pick for Saturday, January 3, 2026 (8:00 pm ET start time) is Seahawks 31 49ers 24.
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NFL Betting Trends
Seattle Seahawks: 16-7 ATS in road games. 6-2 ATS as a road favorite of 7 points or less. 8-3 ATS in games played on a grass field. 5-1 ATS revenging a home loss against an opponent. 7-4 OVER after allowing 14 points or less last game.
San Francisco 49ers: 2-7 ATS as an underdog. 4-10 ATS in a home game where the total is greater than or equal to 45.5. 1-7 ATS after a win by 6 or less points. 31-20 OVER in all games. 13-4 OVER vs. good offensive teams - scoring 24 or more points/game.
Key Injuries
Seattle Seahawks: R. Ouzts (FB) Injured - Neck. J. Reed (DL) Injured - Wrist. C. Bryant (S) Out - Knee. C. White (WR) Injured - Abdomen. A. Lucas (OT) Injured - Neck. C. Cross (OT) Out - Hamstring. A. Barner (TE) Injured - Elbow.
San Francisco 49ers: T. Williams (OT) Injured - Rest. C. McCaffrey (RB) Injured - Rest. G. Kittle (TE) Questionable - Ankle. Y. Gross-Matos (DL) Injured - Knee. S. Okuayinonu (DL) Injured - Ankle. R. Green (CB) Out - Neck. T. Bethune (LB) Injured - Ankle. R. Pearsall (WR) Questionable - Knee. K. Rourke (QB) Out - Knee.
Notable Quotes
“Same story every week: We didn’t flinch. A big emphasis this week was, ‘Can we stack plays in all three phases?’ It took us a half to do it but I felt like in the second half, we did a great job.” - Mike Macdonald after his team’s win against the Panthers in their last game.
“We’ve earned this. This is the game we want. We love that it’s here. We have an opportunity to never leave here again this year.” - Kyle Shanahan after his team’s win against the Bears in their last game.
Starting Lineups
Seattle Seahawks
WR Smith-Njigba, Jaxon
WR Bobo, Jake
WR Kupp, Cooper
TE Barner, AJ
QB Darnold, Sam
RB Walker III, Kenneth
FB Ouzts, Robbie
San Francisco 49ers
WR Pearsall, Ricky
WR Jennings, Jauan
WR Robinson, Demarcus
TE Kittle, George
QB Purdy, Brock
RB McCaffrey, Christian
FB Juszczyk, Kyle
Statistical Leaders
Seattle Seahawks
Passing: Sam Darnold (3,850)
Rushing: Kenneth Walker III (930)
Receiving: Jaxon Smith-Njigba (1,709)
Touchdowns: Zach Charbonnet (11)
San Francisco 49ers
Passing: Mac Jones (2,151)
Rushing: Christian McCaffrey (1,179)
Receiving: Christian McCaffrey (890)
Touchdowns: Christian McCaffrey (17)
Coaches:
Seattle Seahawks: Mike Macdonald (2nd season)
San Francisco 49ers: Kyle Shanahan (9th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
