Seattle Mariners vs Minnesota Twins Prediction, Preview and Odds - 06/25/2025

Game Time: 7:40 pm ET, Wednesday, June 25, 2025

Venue:  Target Field, Minneapolis, MN

Where to Watch:  ROOT Sports NW, TWINS.tv

DraftKings:  Moneyline odds:  Mariners +108, Twins -132; Over/Under:  8 runs

Bet365:  Moneyline odds:  Mariners +110, Twins -130; Over/Under:  8 runs

BetMGM:  Moneyline odds:  Mariners +110, Twins -130; Over/Under:  8 runs

Seattle Mariners:  40-37 (2nd place, AL West)

Minnesota Twins:  37-41 (4th place, AL Central)

Do not miss out on our expert handicapper analysis! Brian Bitler is on a HOT STREAK in the MLB on an 11-4 MLB RUN for +$7,800 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Seattle Mariners:  7-3 last 10

Minnesota Twins:  1-9 last 10

The Mariners are entering this series off a win and won their 3-game series against the Chicago Cubs 2-1 in their last series. They enter this game with a 40-37 record overall and have a road record of 20-18. This is the 3rd game of a 4-game series with the Twins on Wednesday with the 2nd game still to be played on Tuesday. The Mariners won the series opener on Monday. Their offense ranks 9th in the MLB with a .737 OPS. Luis Castillo is their starting pitcher on Tuesday while George Kirby is making his start in this game on Wednesday. He is 1-3 with a 6.16 ERA this season. His team won their last 3 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 4 ER, 2 HR, and 1 BB with 3 SO on 7 hits through 5 IP against the Chicago Cubs.

The Twins are entering this series off a loss and got swept in their 3-game series against the Milwaukee Brewers 3-0 in their last series. They enter this game with a 37-41 record overall and have a home record of 20-16. This is the 3rd game of a 4-game series with the Mariners on Wednesday with the 2nd game of this series still to be played on Tuesday. The Twins lost the 1st game of this series on Monday. Their offense ranks 16th in the MLB with a .710 OPS. Chris Paddack is their starting pitcher on Tuesday while Joe Ryan is making his start in this game on Wednesday. He is 7-3 with a 3.06 ERA this season. His team lost their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 3 earned runs, 0 homers, and 3 walks with 7 strikeouts on 3 hits through 5.1 innings pitched against the Milwaukee Brewers.

The current betting odds have the Twins listed as a slight favorite in this game according to Draftkings Sportsbook. The Mariners have looked good in their games this season with their 40-37 record overall which has them right near the top of the AL West. They have been a good road team too with their 20-18 road record this season. Meanwhile, the Twins haven't looked great in their games this season with their 37-41 record overall which has them right near the bottom of the AL Central. They have looked better in their own ballpark though with their 20-16 home record this season. The Mariners have been getting really hot lately as they are 7-3 in their last 10 games while the Twins have been in a terrible slump, going 1-9 in their last 10. As bad as the Twins have been lately, they do have one of their best starters on the mound here so this is their best shot to try and turn things around with a much needed bounce back win. Ryan is on the mound for the Twins and he has pretty much been their ace this year. He is 7-3 with a 3.06 ERA and hasn't been giving up many runs all season. He did give up 3 earned runs in his last start and the team has lost 2 games in a row now with him starting, but he hasn't looked bad himself lately so he will be looking to bounce back with a better start and the team is going to be desperate for a win too. Kirby is on the mound for the Mariners here and he hasn't looked good this season. He is 1-3 with a 6.16 ERA and he has been giving up a ton of runs in his starts, especially on the road. The team has won 3 games in a row now with him starting, but he still gave up 4 earned runs in his last start and that has been a common theme for him lately. This is the spark that the Twins offense needs in this series so look for them to bounce back in this one. The best way to place a bet here is on the Twins to win this game. 

Mariners Twins Prediction:  Our MLB Pick for Wednesday, June 25, 2025 (7:40 pm ET start time) is Twins 5 Mariners 4.

Don't miss our champion handicappers free picks, best bets, and expert baseball picks today.  And if you enjoyed this Seattle Mariners Minnesota Twins prediction, be sure to drop by every day for our daily MLB projections and previews.

Seattle Mariners: 92-85 (+6.3 units) on the moneyline when the money line is +125 to -125. 136-103 (+9 units) on the moneyline vs. an AL team with an on base percentage .330 or worse. 86-57 (+6.1 units) on the moneyline vs. AL teams scoring 4.4 or less runs/game on the season. 45-29 OVER as a road underdog of +100 to +150.

Minnesota Twins: 208-199 (-37.1 units) on the moneyline in all games. 112-90 (-16.4 units) on the moneyline in home games. 158-118 (-15.4 units) on the moneyline as a favorite of -110 or higher. 52-33 OVER against AL West opponents.

Seattle Mariners:  T. Thornton (RP) Day To Day - Heat Illness. B. Miller (SP) Fifteen Day IL - Elbow. C. Snider (RP) Fifteen Day IL - Forearm. G. Santos (RP) Sixty Day IL - Knee. V. Robles (RF) Sixty Day IL - Shoulder. R. Bliss (2B) Sixty Day IL - Biceps.

Minnesota Twins:  W. Castro (2B) Day To Day - Wrist. R. Lewis (3B) Ten Day IL - Hamstring. P. Lopez (SP) Sixty Day IL - Shoulder. Z. Matthews (SP) Fifteen Day IL - Shoulder. L. Keaschall (2B) Sixty Day IL - Forearm.

“It's going to be mixing and matching as we go. And Donnie swung the bat very well [last weekend]. We've seen him at first base do a great job. So, just kind of continuing to find spots for guys to play, and things will look different from time to time. As we look at it, obviously, the way guys play and what they do on the field is a big factor in that.” - Dan Wilson after his team’s win against the Twins in their game on Monday.

“[Selling is] not my focus right now by any means. I think when you think you have the team that you believe you have, and you hope you get healthier and get guys back here soon, that you feel like this group … is capable of putting together good baseball, it’s hard for you to think like that. If we have to cross that bridge, we’ll cross that bridge later, but that is not at all our focus right now. It’s to figure out how to get this team right back to where it needs to be." - Team President Derek Falvey on the team after their loss against the Mariners in their game on Monday.

J.P. Crawford (L) SS

Julio Rodríguez (R) CF

Cal Raleigh (S) C

Jorge Polanco (S) DH

Randy Arozarena (R) LF

Luke Raley (L) 1B

Dominic Canzone (L) RF

Ben Williamson (R) 3B

Cole Young (L) 2B

Byron Buxton (R) CF

Matt Wallner (L) DH

Brooks Lee (S) 3B

Trevor Larnach (L) RF

Carlos Correa (R) SS

Ty France (R) 1B

Kody Clemens (L) 2B

Harrison Bader (R) LF

Christian Vázquez (R) C

Batting Average:  Dominic Canzone (.308)

Hits:  Julio Rodríguez (80)

Home Runs:  Cal Raleigh (32)

RBI:  Cal Raleigh (68)

Stolen Bases:  Randy Arozarena (14)

Wins:  Bryan Woo (7)

Saves:  Andrés Muñoz (18)

ERA:  Matt Brash (0.00)

Batting Average:  Luke Keaschall (.368)

Hits:  Ty France (74)

Home Runs:  Byron Buxton (17)

RBI:  Byron Buxton (47)

Stolen Bases:  Byron Buxton (13)

Wins:  Joe Ryan (7)

Saves:  Jhoan Duran (10)

ERA:  Danny Coulombe (0.87)

Managers:

Seattle Mariners: Dan Wilson (2nd season)

Minnesota Twins: Rocco Baldelli (7th season)