Seattle Mariners vs Cleveland Guardians Prediction, Preview and Odds - 06/27/2026

Game Time: 7:10 pm ET, Saturday, June 27, 2026

Venue:  Progressive Field, Cleveland, OH

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Mariners -149, Guardians +123; Over/Under:  8 runs

Bet365:  Moneyline odds:  Mariners -150, Guardians +125; Over/Under:  8 runs

BetMGM:  Moneyline odds:  Mariners -150, Guardians +125; Over/Under:  8 runs

Seattle Mariners:  41-41 (1st place, AL West)

Cleveland Guardians:  42-39 (2nd place, AL Central)

Do not miss out on our expert handicapper analysis! Brian Bitler is on a HOT STREAK in MLB on an 8-3 MLB RUN for +$5,180 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Seattle Mariners:  4-6 last 10

Cleveland Guardians:  4-6 last 10

The Mariners are entering this series off a loss and lost their 3-game series against the Pittsburgh Pirates 2-1 in their last series. They enter this game with a 41-41 record overall and have a road record of 19-22. This is the 2nd game of a 3-game series with the Guardians on Saturday with the series opener still to be played on Friday. Their offense ranks 27th in the MLB with a .695 OPS. Luis Castillo is their starting pitcher on Friday while Logan Gilbert is making his start in this game on Saturday. He is 6-4 with a 3.29 ERA this season. His team won their last 6 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 1 ER, 1 HR, and 2 BB with 8 SO on 3 hits through 6.1 IP against the Boston Red Sox.

The Guardians are entering this series off a win and lost their 3-game series against the Chicago White Sox 2-1 in their last series. They enter this game with a 42-39 record overall and have a home record of 19-17. This is the 2nd game of a 3-game series with the Mariners on Saturday with the 1st game of this series still to be played on Friday. Their offense ranks 28th in the MLB with a .679 OPS. Joey Cantillo is their starting pitcher on Friday while Slade Cecconi is making his start in this game on Saturday. He is 3-6 with a 4.48 ERA this season. His team lost their last 4 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 2 earned runs, 1 homer, and 2 walks with 1 strikeout on 6 hits through 6 innings pitched against the Houston Astros.

The current betting odds have the Mariners listed as a favorite in this game according to Draftkings Sportsbook. The Guardians have looked good in their games this season with their 42-39 record overall which has them right near the top of the AL Central. They have looked good in their own ballpark too with their 19-17 home record this season. Meanwhile, the Mariners have looked good in their games this season with their 41-41 record overall which has them right at the top of the AL west. They haven't been a great road team though with their 19-22 road record this year. Neither team has looked great lately as both are 4-6 in their last 10 games respectively, but this is a pitching matchup that the Mariners can take advantage of to break out of their recent slump. They are going with Gilbert in this one and he has looked good this season. He is 6-4 with a 3.29 ERA and the team has been having a ton of success with him lately. He only allowed 1 earned run in his last start which has been a common theme for him lately and the team has won 6 games in a row now with him starting. The Guardians are going with Cecconi in this one and he hasn't looked great this season. He is 3-6 with a 4.48 ERA and has looked better lately, but his team has still had a lot of trouble with him. He only gave up 2 earned runs in his last start, but that hasn't been a common theme for him this season and his team has still lost 4 games in a row now with him starting. The Mariners are going to be able to take advantage of this better pitching matchup and even though their offense hasn't looked great lately, the Guardians haven't either with one of the worst offenses in the league. The best way to place a bet here is on the Mariners to win this game. 

Mariners Guardians Prediction:  Our MLB Pick for Saturday, June 27, 2026 (7:10 pm ET start time) is Mariners 4 Guardians 2.

Don't miss our champion handicappers free picks, best bets, and expert baseball picks today.  And if you enjoyed this Seattle Mariners Cleveland Guardians prediction, be sure to drop by every day for our daily MLB projections and previews.

Seattle Mariners: 48-44 (-5.3 units) on the moneyline against AL Central opponents. 222-197 (-12.7 units) on the moneyline in all games. 97-112 (-25.8 units) on the moneyline in road games. 5-1 UNDER on the road vs. a team with a good bullpen whose WHIP is 1.350 or better.

Cleveland Guardians: 45-34 (+10.3 units) on the moneyline against AL West opponents. 227-190 (+34.3 units) on the moneyline in all games. 118-87 (+11.6 units) on the moneyline in home games. 23-17 UNDER vs. an AL team with a slugging percentage .410 or worse on the season.

Seattle Mariners:  W. Wilson (3B) Sixty Day IL - Thumb. M. Brash (RP) Fifteen Day IL - Lat. C. Criswell (RP) Fifteen Day IL - Shoulder. B. Donovan (3B) Ten Day IL - Groin. C. Vargas (RP) Sixty Day IL - Lat. L. Evans (SP) Sixty Day IL - Arm.

Cleveland Guardians:  C. DeLauter (RF) Ten Day IL - Rib. A. Martinez (LF) Ten Day IL - Foot. J. Ramirez (3B) Ten Day IL - Hand.

“Frustrating one today. I thought we had some opportunities offensively where we got guys on base and hit the ball hard (and it) seemed to go right at them.” - Dan Wilson after his team’s loss against the Pirates in their game on Thursday.

"I think we're playing the guys that we want to play, and I think we're matching up when we need to, when we have to. But we've got to trust all 13 [position players] like we are. We're figuring it out, but we're just not getting anything going right now, and it's tough." - Stephen Vogt after his team’s win against the White Sox in their game on Wednesday. 

J.P. Crawford (L) 3B

Cal Raleigh (S) DH

Julio Rodríguez (R) CF

Josh Naylor (L) 1B

Randy Arozarena (R) LF

Luke Raley (L) RF

Cole Young (L) 2B

Mitch Garver (R) C

Colt Emerson (L) SS

Travis Bazzana (L) 2B

Brayan Rocchio (S) SS

David Fry (R) LF

Kyle Manzardo (L) 1B

Rhys Hoskins (R) DH

Kahlil Watson (L) RF

Daniel Schneemann (L) 3B

Patrick Bailey (S) C

Steven Kwan (L) CF

Batting Average:  Randy Arozarena (.284)

Hits:  Julio Rodríguez (80)

Home Runs:  Luke Raley (14)

RBI:  Julio Rodríguez (38)

Stolen Bases:  Randy Arozarena (19)

Wins:  Logan Gilbert (6)

Saves:  Andrés Muñoz (14)

ERA:  Matt Brash (0.54)

Batting Average:  Brayan Rocchio (.269)

Hits:  Brayan Rocchio (70)

Home Runs:  Angel Martínez (11)

RBI:  Chase DeLauter (34)

Stolen Bases:  José Ramírez (24)

Wins:  Gavin Williams (9)

Saves:  Cade Smith (24)

ERA:  Logan Allen (0.00)

Managers:

Seattle Mariners: Dan Wilson (3rd season)

Cleveland Guardians: Stephen Vogt (3rd season)