Seattle Mariners vs Cleveland Guardians Prediction, Preview and Odds - 06/26/2026

Game Time: 7:10 pm ET, Friday, June 26, 2026

Venue:  Progressive Field, Cleveland, OH

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Mariners -105, Guardians -115; Over/Under:  7.5 runs

Bet365:  Moneyline odds:  Mariners -105, Guardians -115; Over/Under:  7.5 runs

BetMGM:  Moneyline odds:  Mariners -105, Guardians -115; Over/Under:  7.5 runs

Seattle Mariners:  41-41 (1st place, AL West)

Cleveland Guardians:  42-39 (2nd place, AL Central)

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Seattle Mariners:  4-6 last 10

Cleveland Guardians:  4-6 last 10

The Mariners are entering this series off a loss and lost their 3-game series against the Pittsburgh Pirates 2-1 in their last series. They enter this game with a 41-41 record overall and have a road record of 19-22. This is the series opener of a 3-game series with the Guardians on Friday. Their offense ranks 27th in the MLB with a .695 OPS. Bryce Miller was their starting pitcher on Thursday while Luis Castillo is making his start in this game on Friday. He is 2-6 with a 5.22 ERA this season. His team lost their last 3 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 4 ER, 0 HR, and 0 BB with 4 SO on 7 hits through 4 IP against the Boston Red Sox.

The Guardians are entering this series off a win and lost their 3-game series against the Chicago White Sox 2-1 in their last series. They enter this game with a 42-39 record overall and have a home record of 19-17. This is the 1st game of a 3-game series with the Mariners on Friday and they have Thursday off as a day of rest. Their offense ranks 28th in the MLB with a .679 OPS. Tanner Bibee was their starting pitcher on Wednesday while Joey Cantillo is making his start in this game on Friday. He is 6-3 with a 4.05 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 0 homers, and 1 walk with 9 strikeouts on 4 hits through 8 innings pitched against the Houston Astros.

The current betting odds have the Guardians listed as a slight favorite in this game according to Draftkings Sportsbook. The Guardians have looked good in their games this season with their 42-39 record overall which has them right near the top of the AL Central. They have looked good in their own ballpark too with their 19-17 home record this season. Meanwhile, the Mariners have looked good in their games this season with their 41-41 record overall which has them right at the top of the AL west. They haven't been a great road team though with their 19-22 road record this year. The Guardians haven't looked great in their games lately as they are 4-6 in their last 10, but the Mariners are also 4-6 and haven't looked any better. Castillo is on the mound for the Mariners in this one and he hasn't looked good this season. He is 2-6 with a 5.22 ERA and he has been giving up a lot of runs lately. He is coming off another bad start in which he gave up 4 earned runs, something that has been a common theme for him lately, and the team has had trouble with him too, losing 3 games in a row now with him as the starter. The Guardians are going with Cantillo in this one and he hasn't looked bad this year. He is 6-3 with a 4.05 ERA and he has looked a lot better lately. He only gave up 1 earned run in his last start which is starting to become a common theme for him, and the team has had more success lately too, winning 2 games in a row now with him starting. The Guardians don't have a great offense this season, but this Mariners offense has looked terrible lately and the Guardians do have the better pitching staff as a whole to give them the edge in this one. The best way to place a bet here is on the Guardians to win this game. 

Mariners Guardians Prediction:  Our MLB Pick for Friday, June 26, 2026 (7:10 pm ET start time) is Guardians 4 Mariners 2.

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Seattle Mariners: 48-44 (-5.3 units) on the moneyline against AL Central opponents. 222-196 (-11.2 units) on the moneyline in all games. 97-111 (-24.3 units) on the moneyline in road games. 5-1 UNDER on the road vs. a team with a good bullpen whose WHIP is 1.350 or better.

Cleveland Guardians: 45-34 (+10.3 units) on the moneyline against AL West opponents. 227-190 (+34.3 units) on the moneyline in all games. 130-79 (+22.1 units) on the moneyline as a favorite of -110 or higher. 8-3 UNDER after a one run win.

Seattle Mariners:  W. Wilson (3B) Sixty Day IL - Thumb. M. Brash (RP) Fifteen Day IL - Lat. C. Criswell (RP) Fifteen Day IL - Shoulder. B. Donovan (3B) Ten Day IL - Groin. C. Vargas (RP) Sixty Day IL - Lat. L. Evans (SP) Sixty Day IL - Arm.

Cleveland Guardians:  C. DeLauter (RF) Ten Day IL - Rib. A. Martinez (LF) Ten Day IL - Foot. J. Ramirez (3B) Ten Day IL - Hand.

“Honestly, if I had answers for you, I’d have answers for myself. It seems like I’m always digging for answers. I’m looking everywhere. I just don’t know. I wish I had a better answer than that.” - Bryan Woo after their loss against the Pirates in their game on Wednesday. 

"I think we're playing the guys that we want to play, and I think we're matching up when we need to, when we have to. But we've got to trust all 13 [position players] like we are. We're figuring it out, but we're just not getting anything going right now, and it's tough." - Stephen Vogt after his team’s win against the White Sox in their game on Wednesday. 

J.P. Crawford (L) 3B

Cal Raleigh (S) DH

Julio Rodríguez (R) CF

Josh Naylor (L) 1B

Randy Arozarena (R) LF

Luke Raley (L) RF

Cole Young (L) 2B

Mitch Garver (R) C

Colt Emerson (L) SS

Travis Bazzana (L) 2B

Brayan Rocchio (S) SS

David Fry (R) LF

Kyle Manzardo (L) 1B

Rhys Hoskins (R) DH

Kahlil Watson (L) RF

Daniel Schneemann (L) 3B

Patrick Bailey (S) C

Steven Kwan (L) CF

Batting Average:  Randy Arozarena (.284)

Hits:  Julio Rodríguez (80)

Home Runs:  Luke Raley (14)

RBI:  Julio Rodríguez (38)

Stolen Bases:  Randy Arozarena (19)

Wins:  Logan Gilbert (6)

Saves:  Andrés Muñoz (14)

ERA:  Matt Brash (0.54)

Batting Average:  Brayan Rocchio (.269)

Hits:  Brayan Rocchio (70)

Home Runs:  Angel Martínez (11)

RBI:  Chase DeLauter (34)

Stolen Bases:  José Ramírez (24)

Wins:  Gavin Williams (9)

Saves:  Cade Smith (24)

ERA:  Logan Allen (0.00)

Managers:

Seattle Mariners: Dan Wilson (3rd season)

Cleveland Guardians: Stephen Vogt (3rd season)