San Francisco Giants vs New York Yankees Prediction, Preview and Odds - 04/11/2025

Game Time: 7:05 pm ET, Friday, April 11, 2025

Venue:  Yankee Stadium, Bronx, NY

Where to Watch:  YES

DraftKings:  Moneyline odds:  Giants -105, Yankees -115; Over/Under:  8 runs

Bet365:  Moneyline odds:  Giants -105, Yankees -115; Over/Under:  8 runs

BetMGM:  Moneyline odds:  Giants -105, Yankees -115; Over/Under:  8 runs

San Francisco Giants:  9-3 (2nd place, NL West)

New York Yankees:  7-5 (2nd place, AL East)

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San Francisco Giants:  8-2 last 10

New York Yankees:  5-5 last 10

The Giants are entering this series off a win but lost their 3-game series against the Cincinnati Reds 2-1 in their last series. They enter this game with a 9-3 record overall and have a road record of 5-1. This is the series opener of a 3-game series with the Yankees on Friday and they have Thursday off as a day of rest. Their offense ranks 15th in the MLB with a .692 OPS. Justin Verlander was their starting pitcher on Wednesday while Robbie Ray is making his start in this game on Friday. He is 2-0 with a 3.18 ERA this season. His team won their 2 games this season with him making an appearance. In his last MLB regular season start, he allowed 1 ER, 1 HR, and 5 BB with 2 Ks on 4 hits through 6 IP against the Seattle Mariners.

The Yankees are entering this series off a win but lost their 3-game series against the Detroit Tigers 2-1 in their last series. They enter this game with a 7-5 record overall and have a home record of 4-2. This is the 1st game of a 3-game series with the Giants on Friday and they have Thursday off as a day of rest. Their offense ranks 1st in the MLB with a .855 OPS. Max Fried was their starting pitcher on Wednesday while Marcus Stroman is making his start in this game on Friday. He is 0-0 with a 7.27 ERA this season. His team won their 2 games this season with him making an appearance. In his last MLB regular season start, he allowed 4 earned runs, 0 homers, and 3 BB with 3 strikeouts on 3 hits through 4 innings played against the Pittsburgh Pirates.

The current betting odds have the Giants listed as a slight underdog in this game according to Draftkings Sportsbook. The Giants have looked really good in their games this season with their 9-3 record overall which has them right near the top of the NL West with a great start to the season. They have also been a great road team so far with their 5-1 road record this season. Meanwhile, the Yankees have looked good in their games this season with their 7-5 record overall which has them right near the top of the AL East with a good start to the season. They have looked good in their ballpark too with their 4-2 home record. The Yankees got off to a really hot start this season and were putting up a ton of runs, still with the best offense in the MLB at the moment, but lately they haven't looked as good and have been starting to cool off. They just lost their last series against the Tigers and their offense was not good in that series. The Giants are also coming off a series loss to the Reds in their last one, but their pitching was great even in some of their losses this season and they have the better pitching matchup in this one. Ray is coming off a good start in his last one and hasn't been giving up many runs this year while Stroman hasn't pitched well in either of his 2 starts even though his team still got the wins. He is due for a loss with the way he has been pitching to start the season and the Giants have the bats to do some damage here. The best way to place a bet here is on the Giants to win this game. 

Giants Yankees Prediction:  Our MLB Pick for Friday, April 11, 2025 (7:05 pm ET start time) is Giants 5 Yankees 2.

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San Francisco Giants: 168-167 (-14.2 units) on the moneyline in all games. 77-89 (-7.1 units) on the moneyline in road games. 120-121 (-11.4 units) on the moneyline against right-handed starters. 46-25 OVER as a road underdog of +100 to +150. 

New York Yankees: 103-84 (+12.9 units) on the moneyline when playing against a team with a winning record. 61-52 (+6.2 units) on the moneyline vs. teams outscoring opp by 0.5 or more runs/game on the season. 97-72 (+11.3 units) on the moneyline in the first half of the season. 10-4 OVER vs. NL teams allowing 4.0 or less runs/game on the season.

San Francisco Giants:  T. Murphy (C) Sixty Day IL - Back. J. Encarnacion (RF) Ten Day IL - Finger.

New York Yankees:  J. Brubaker (SP) Sixty Day IL - Ribs. J. Cousins (RP) Sixty Day IL - Elbow. D. LeMahieu (3B) Ten Day IL - Calf. S. Effross (RP) Fifteen Day IL - Hamstring. C. Beeter (SP) Fifteen Day IL - Shoulder. G. Stanton (DH) Ten Day IL - Elbow. C. Schmidt (SP) Fifteen Day IL - Rotator Cuff. J. Loaisiga (RP) Fifteen Day IL - Elbow. L. Gil (SP) Sixty Day IL - Back. G. Cole (SP) Sixty Day IL - Elbow.

“We’re going to make subtle moves -- you know, lefty and righty -- but I think Buster is trying to just create some stability here. So far, so good.” - Bob Melvin after his team’s win against the Reds in their game on Wednesday.

“I guess it’s just probably confirmed some things. I mean, he’s such a pro. His preparation. His attention to detail. His professionalism is off the charts. Then you look at him. This guy is probably on his way to the Hall of Fame, and he’s dripping in humility. The message with me is ‘whatever I need from him.’ It’s no, ‘I want to hit here. I want to play here.’ If it’s a day off, he’s ready. [He’s] going to play well for us between the lines but is going to elevate our room, too.” - Aaron Boone on Paul Goldschmidt after his team’s win against the Tigers in their game on Wednesday.

LaMonte Wade Jr. (L) 1B

Willy Adames (R) SS

Jung Hoo Lee (L) CF

Matt Chapman (R) 3B

Heliot Ramos (R) LF

Mike Yastrzemski (L) RF

Wilmer Flores (R) DH

Patrick Bailey (S) C

Tyler Fitzgerald (R) 2B

Ben Rice (L) DH

Aaron Judge (R) RF

Cody Bellinger (L) CF

Paul Goldschmidt (R) 1B

Jazz Chisholm Jr. (L) 2B

Anthony Volpe (R) SS

Jasson Domínguez (S) LF

J.C. Escarra (L) C

Oswaldo Cabrera (S) 3B

Batting Average:  Mike Yastrzemski (.344)

Hits:  Jung Hoo Lee (15)

Home Runs:  Wilmer Flores (5)

RBI:  Wilmer Flores (14)

Stolen Bases:  Tyler Fitzgerald (3)

Wins:  Robbie Ray (2)

Saves:  Ryan Walker (3)

ERA:  Hayden Birdsong (0.00)

Batting Average:  Paul Goldschmidt (.383)

Hits:  Paul Goldschmidt (18)

Home Runs:  Aaron Judge (6)

RBI:  Aaron Judge (20)

Stolen Bases:  Jazz Chisholm (4)

Wins:  Max Fried (2)

Saves:  Luke Weaver (1)

ERA:  Yoendrys Gómez (0.00)

Managers:

San Francisco Giants: Bob Melvin (2nd season)

New York Yankees: Aaron Boone (8th season)