San Francisco 49ers vs Pittsburgh Steelers Prediction, Preview and Odds - 09/10/2023

Game Time: 1:00 pm ET, Sunday, September 10, 2023

Venue:  Acrisure Stadium, Pittsburgh, PA

Where to Watch:  FOX

DraftKings:  Point Spread:  49ers -2, Steelers +2; Over/Under:  40.5 points

Bet365:  Point Spread:  49ers -2.5, Steelers +2.5; Over/Under:  41 points

BetMGM:  Point Spread:  49ers -2.5, Steelers +2.5; Over/Under:  41 points

San Francisco 49ers:  0-0 (NFC West)

Pittsburgh Steelers:  0-0 (AFC North)

Do not miss out on our expert handicapper analysis! Al McMordie has been dominating the gridiron with 11 Straight Winning NFL Seasons! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

San Francisco 49ers:  N/A

Pittsburgh Steelers:  N/A

The 49ers finished last season with a 13-4 record overall and they were 6-0 in their division games too. They had an 8-1 record in their home games and had a 5-3 record in their road games where they will be in this game. Last season, their offense was averaging 26.5 points per game and their defense was allowing an average of 16.3 points per game. Their offense was also averaging 365.6 yards per game and their defense was allowing an average of 300.6 yards per game. Jimmy Garoppolo led the team in passing yards with 2437, Christian McCaffrey led the team in rushing yards with 746, and Brandon Aiyuk led the team in receiving yards with 1015.

The Steelers finished last season with a 9-8 record overall and they were 3-3 in their division games too. They had a 4-4 record in their home games and had a 5-4 record in their road games where they will be in this game. Last season, their offense was averaging 18.1 points per game and their defense was allowing an average of 20.4 points per game. Their offense was also averaging 322.6 yards per game and their defense was allowing an average of 330.4 yards per game. Kenny Pickett led the team in passing yards with 2404, Najee Harris led the team in rushing yards with 1034, and Diontae Johnson led the team in receiving yards with 882.

The current betting odds have the 49ers listed as a 2 point favorite in this game according to Draftkings Sportsbook. The 49ers were really good last season despite having 3 different QB's start for them during the regular season. They finished with a 13-4 record overall and went all the way to the NFC Finals which they lost to the Eagles. They ended the season with Brock Purdy at QB and ever since putting him in to run this offense, they have been averaging a lot more points scored per game as they were putting up 30+ in most of those games when he was the starter. The 49ers have finally found a solid answer at the QB position and they have a ton of talent on their offense at every position along with a really good defense too that has been their strong suit for years. The Steelers have also improved a lot this season with Pickett now in his 2nd season of the NFL and a really good head coach in Mike Tomlin who always puts out a winning team even when the talent isn't all there. Their defense is still really good and with 2 good defenses here, this game will come down to who has the better offense to crack these good defenses and the 49ers simply have more talent at every position on the offense than the Steelers do. The Steelers will try to keep this game close with their great defense being at home here but the 49ers have too much talent on their offense to be stopped, especially with the explosive element Purdy now brings to this offense. The best way to place a bet here is on the 49ers to cover the spread in this game. 

49ers Steelers Prediction:  Our NFL Pick for Sunday, September 10, 2023 (1:00 pm ET start time) is 49ers 24 Steelers 17.

Don't miss our champion handicappers free picks and expert football picks today. And if you enjoyed this San Francisco 49ers Pittsburgh Steelers prediction, be sure to drop by every day for our weekly NFL predictions and previews.

San Francisco 49ers: 28-45 ATS in a road game where the total is between 38.5 and 42 points. 4-6 ATS in non-conference games. 9-4 UNDER in games where the line is +3 to -3. 8-3 UNDER as a road favorite of 7 points or less. 13-7 UNDER in road games. 

Pittsburgh Steelers: 11-3 ATS in games where the line is +3 to -3. 99-66 ATS as an underdog. 20-13 ATS against NFC West division opponents. 10-5 UNDER in games where the line is +3 to -3. 11-6 UNDER in home games. 

San Francisco 49ers:  T. Hawkins (S) I-R - Hand. A. Parker (DB) I-R - Hamstring. D. Luter Jr. (CB) Out indefinitely - Knee. C. Latu (TE) I-R - Knee. Z. Gonzalez (K) I-R - Calf. J. Moody (K) Out indefinitely - Quadricep. J. Mason (RB) Ques Week 1 - Foot. D. Gray (WR) Out indefinitely - Shoulder. R. McCloud III (WR) Early Oct - Wrist. N. Bosa (DL) Ques Week 1 - Holdout.

Pittsburgh Steelers:  R. Wren (DT) I-R - Achilles. C. Russell (LB) I-R - Knee. C. Trice (DB) I-R - Leg.

“No. I haven’t talked to many people about that. But I know how I feel pretty strongly, and I think everyone would agree with that.” - Kyle Shanahan on trading Nick Bosa.

“There was a level of maturity, a level of football maturity that was exciting. We didn’t scholarship anyone, they earned their spots and we expect contributions from those guys, and increasing contributions as they gain more experience and we push through this journey.” - Mike Tomlin on his team’s roster coming into this new NFL season. 

WR Aiyuk, Brandon 

WR Samuel, Deebo 

WR Jennings, Jauan 

TE Kittle, George 

QB Purdy, Brock 

RB McCaffrey, Christian 

WR Johnson, Diontae 

WR Pickens, George 

WR ROBINSON II, ALLEN 

TE Freiermuth, Pat 

QB Pickett, Kenny 

RB Harris, Najee 

FB Heyward, Connor 

Passing: N/A

Rushing: N/A

Receiving: N/A

Touchdowns: N/A

Passing: N/A

Rushing: N/A

Receiving: N/A

Touchdowns: N/A

Coaches:

San Francisco 49ers: Kyle Shanahan (7th season)

Pittsburgh Steelers: Mike Tomlin (17th season)