San Francisco 49ers vs Philadelphia Eagles Prediction, Preview and Odds - 01/11/2026

Game Time: 4:30 pm ET, Saturday, January 11, 2026

Venue:  Lincoln Financial Field, Philadelphia, PA

Where to Watch:  FOX

DraftKings:  Point Spread:  49ers +4.5, Eagles -4.5; Over/Under:  44.5 points

Bet365:  Point Spread:  49ers +4.5, Eagles -4.5; Over/Under:  45 points

BetMGM:  Point Spread:  49ers +4.5, Eagles -4.5; Over/Under:  45 points

San Francisco 49ers:  12-5 (3rd place, NFC West)

Philadelphia Eagles:  11-6 (1st place, NFC East)

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San Francisco 49ers:  lost their last game at home against the Seattle Seahawks 13-3.

Philadelphia Eagles:  lost their last game at home against the Washington Commanders 24-17.

The 49ers are entering this game with a 12-5 record overall and they have a 4-2 record in their divisional games too. They are 5-3 in their home games, 7-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the Seattle Seahawks 13-3. Brock Purdy was the starting QB and he completed 19/27 passes for 127 passing yards, 0 touchdowns, and 1 interception. Christian McCaffrey led the team in rushing yards with 23. Jauan Jennings led the receivers with 35 receiving yards on 4 receptions. Renardo Green led the defense in that game with 6 solo tackles and 2 assisted tackles while Sam Okuayinonu and Tatum Bethune each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

 

 

 

The Eagles are entering this game with an 11-6 record overall and they have a 3-3 record in their divisional games too. They are 5-3 in their home games, 6-3 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Washington Commanders 24-17. Tanner McKee was the starting QB and he completed 21/40 passes for 241 passing yards, 1 touchdown, and 1 interception. Tank Bigsby led the team in rushing yards with 75 and 1 TD. DeVonta Smith led the receivers with 52 receiving yards on 3 receptions. Jihaad Campbell led the defense in that game with 6 solo tackles and 4 assisted tackles while no one on the defense recorded a sack for them. Jalyx Hunt came away with the only interception for them in that one.

The current betting odds have the Eagles listed as a 4.5 point favorite in this game according to Draftkings Sportsbook. The Eagles have looked good in their games this season with their 11-6 record overall which had them right at the top of the NFC East. They have looked good on their home field too with their 5-3 home record this year. Meanwhile, the 49ers have looked really good in their games this season with their 12-5 record overall, but that record had them near the bottom of the NFC West in a competitive division. They have been a great road team though with their 7-2 road record this year. The 49ers have looked great on offense over the last few weeks, putting up a ton of points in their games, and they have been getting by with a ton of injuries on defense. Their defense hasn't looked great in their games lately though, giving up a ton of points, and their offense really fell flat in their last game against a top defense in the NFL. They are off a 13-3 loss at home to the Seahawks in a game where they had a chance to get the number 1 seed in the NFC, and their offense couldn't do anything in that game. The Eagles haven't looked good offensively all season, but their defense has been carrying the team as they still have one of the best defenses in the NFL, and that defense is going to cause problems for this 49ers offense that looked terrible against a good defense last week. The Eagles were not as dominant as they were last season, but they still have one of the best teams in the NFL with the talent they have, and they are still the defending Super Bowl champions so they aren't going out easily in any games. The best way to place a bet here is on the Eagles to cover the spread in this game.

49ers Eagles Prediction:  Our NFL Pick for Saturday, January 11, 2026 (4:30 pm ET start time) is Eagles 20  49ers 10.

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San Francisco 49ers: 2-8 ATS as an underdog. 0-5 ATS as a road underdog of 7 points or less. 0-3 ATS in playoff games. 14-6 OVER in a road game where the total is between 42.5 and 49 points. 12-4 OVER after playing a division game.

Philadelphia Eagles: 10-5 ATS as a home favorite of 7 points or less. 14-4 ATS after playing a division game. 15-6 ATS vs. good offensive teams - scoring 24 or more points/game. 5-2 OVER against NFC West division opponents. 

San Francisco 49ers:  K. Juszczyk (FB) Injured - Hip. T. Williams (OT) Questionable - Hamstring. C. McCaffrey (RB) Injured - Back. G. Kittle (TE) Questionable - Ankle. Y. Gross-Matos (DL) Injured - Knee. K. White (DL) Questionable - Groin. R. Green (CB) Injured - Neck. R. Pearsall (WR) Questionable - Knee. U. Stout (CB) Questionable - Concussion.

Philadelphia Eagles:  M. Epps (S) Out - Concussion. J. Carter (DL) Out - Hip. L. Johnson (OT) Out - Foot. D. Goedert (TE) Out - Knee. J. Phillips (LB) Out - Ankle. N. Dean (LB) Out - Hamstring. C. Williams (OT) Injured - Shoulder. J. Campbell (LB) Injured - Back.

“We’re ready for it. It would have been nice to have a home game here — or both home games — and get a bye. But it is what it is. This team’s been through a lot this year. Now we got to do it the hard way.” - Kyle Shanahan after his team’s loss against the Seahawks in their last game. 

“I knew this was an outcome, that these things could happen. One thing I could guarantee was giving them rest. I couldn't guarantee them anything else. Being healthy and going into the playoffs healthy is a big deal for us.” - Nick Sirianni after his team’s loss against the Commanders in their last game. 

WR Bourne, Kendrick

WR Jennings, Jauan

WR Robinson, Demarcus

TE Kittle, George

QB Purdy, Brock

RB McCaffrey, Christian

FB Juszczyk, Kyle

WR Brown, A.J. 

WR Dotson, Jahan

WR Smith, DeVonta

TE Calcaterra, Grant

QB Hurts, Jalen

RB Barkley, Saquon

Passing: Brock Purdy (2,167)

Rushing: Christian McCaffrey (1,202)

Receiving: Christian McCaffrey (924)

Touchdowns: Christian McCaffrey (17)

Passing: Jalen Hurts (3,224)

Rushing: Saquon Barkley (1,140)

Receiving: DeVonta Smith (1,008)

Touchdowns: Dallas Goedert (11)

Coaches:

San Francisco 49ers: Kyle Shanahan (9th season)

Philadelphia Eagles: Nick Sirianni (5th season)