by Rod Pearson
Tuesday, Oct 28, 2025
Game Time: 1:00 pm ET, Sunday, November 2, 2025
Venue: MetLife Stadium, East Rutherford, NJ
Where to Watch: CBS
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: 49ers -2.5, Giants +2.5; Over/Under: 48.5 points
Bet365: Point Spread: 49ers -2.5, Giants +2.5; Over/Under: 48.5 points
BetMGM: Point Spread: 49ers -2.5, Giants +2.5; Over/Under: 48.5 points
Season Record
San Francisco 49ers: 5-3 (3rd place, NFC West)
New York Giants: 2-6 (4th place, NFC East)
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Recent Form
San Francisco 49ers: lost their last game on the road against the Houston Texans 26-15.
New York Giants: lost their last game on the road against the Philadelphia Eagles 38-20.
San Francisco 49ers vs New York Giants Preview and Analysis
The 49ers are entering this game with a 5-3 record overall and they have a 3-0 record in their divisional games too. They are 2-1 in their home games, 3-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the Houston Texans 26-15. Mac Jones was the starting QB and he completed 19/32 passes for 193 passing yards, 2 touchdowns, and 1 interception. Christian McCaffrey led the team in rushing yards with 25. Jauan Jennings led the receivers with 45 receiving yards on 4 receptions. Dee Winters led the defense in that game with 7 solo tackles and 4 assisted tackles while no one on the defense recorded a sack for them. Deommodore Lenoir came away with the only interception for them in that one.
The Giants are entering this game with a 2-6 record overall and they have a 1-3 record in their divisional games too. They are 2-1 in their home games, 0-5 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Philadelphia Eagles 38-20. Jaxson Dart was the starting QB and he completed 14/24 passes for 193 passing yards, 1 touchdown, and 0 interceptions. Tyrone Tracy Jr. led the team in rushing yards with 39. Wan'Dale Robinson led the receivers with 48 receiving yards on 3 receptions. Bobby Okereke led the defense in that game with 7 solo tackles and 1 assisted tackle while Bobby Okereke, Rakeem Nunez-Roches, and Brian Burns each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.
49ers vs Giants Prediction
The current betting odds have the 49ers listed as a 2.5 point favorite in this game according to Draftkings Sportsbook. The 49ers have looked good in their games this season with their 5-3 record overall, but that record has them right near the bottom of the NFC West in a competitive division. They continue to pick up wins even though they have been plagued by many injuries this season, but lately they have been more up and down. They are off a 26-15 loss to the Texans in their last one, but the Texans do have one of the best defenses in the NFL. The 49ers will be looking to bounce back after that loss and this is a team they can definitely beat up on. Meanwhile, the Giants haven't looked great in their games this season with their 2-6 record overall which has them right at the bottom of the NFC East. They had a really exciting stretch with their rookies starting to break out, but they have started to come back down to Earth now. They blew a big lead on the road in Denver, losing 33-32 to the Broncos, and now they are off a 38-20 loss to the Eagles in their last one. They also lost Cam Skattebo to injury and that is going to be a huge loss for this offense that was starting to find a spark with him and Dart. This Giants team is right back where they started the season, dealing with many key injuries now too, and the 49ers are a well coached playoff team looking to bounce back. The best way to place a bet here is on the 49ers to cover the spread in this game.
49ers Giants Prediction: Our NFL Pick for Sunday, November 2, 2025 (1:00 pm ET start time) is 49ers 23 Giants 13.
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NFL Betting Trends
San Francisco 49ers: 18-26 ATS in all games. 6-13 ATS after playing their last game on the road. 3-6 ATS vs. bad defensive teams who give up 24 or more points/game. 6-3 UNDER vs. bad defensive teams who give up 24 or more points/game. 7-4 UNDER versus poor defensive teams - allowing 350 yards/game or more.
New York Giants: 8-4 ATS after playing a division game. 10-5 ATS off a road loss. 5-1 ATS off a road loss against a division rival. 26-16 UNDER in all games. 10-0 UNDER in games where the line is +3 to -3. 7-3 UNDER in a home game where the total is between 42.5 and 49 points.
Key Injuries
San Francisco 49ers: T. Williams (OT) Injured - Rest. J. Brendel (OG) Injured - Hamstring. C. McCaffrey (RB) Injured - NRI. G. Kittle (TE) Injured - Oblique. M. Jones (QB) Injured - Knee. K. Davis (DL) Injured - Hand. B. Huff (DL) Injured - Hamstring. J. Elliott (DL) Injured - Ankle. Y. Gross-Matos (DL) Injured - Knee. J. Jennings (WR) Injured - Ankle. K. White (DL) Injured - NRI. B. Purdy (QB) Injured - Toe. S. Burford (OG) Injured - Knee. S. Okuayinonu (DL) Injured - Ankle. D. Winters (LB) Injured - Knee. B. Bartch (OG) Injured - Ankle. R. Pearsall (WR) Injured - Knee. U. Stout (CB) Injured - Shoulder. A. Collins (DL) Injured - Shoulder.
New York Giants: C. Manhertz (TE) Injured - Illness. G. Van Roten (OG) Injured - Rest. J. Eluemunor (OG) Injured - Pec. C. Golston (DL) Injured - Neck. P. Adebo (CB) Injured - Knee. J. Holland (S) Injured - Knee. D. Bellinger (TE) Injured - Neck. C. Flott (CB) Injured - Concussion. A. Green (CB) Injured - Hamstring. J. Hyatt (WR) Injured - Tooth. R. Payton (CB) Injured - Groin. B. Collins (WR) Injured - Quad.
Notable Quotes
“There’s not much to sugarcoat there. I was real disappointed in the way we looked for all four quarters. First half was unacceptable and the second half didn’t get much better. Not much to say about it except that.” - Kyle Shanahan after his team’s loss against the Texans in their last game.
“They controlled the line of scrimmage and that was a major point of emphasis and give them credit for doing that. When a team runs for nearly 300 yards, it’s pretty difficult to control the game, if you will. And we missed out on some opportunities.” - Brian Daboll after his team’s loss against the Eagles in their last game.
Starting Lineups
San Francisco 49ers
WR Bourne, Kendrick
WR Robinson, Demarcus
WR Jennings, Jauan
TE Kittle, George
QB Jones, Mac
RB McCaffrey, Christian
FB Juszczyk, Kyle
New York Giants
WR Hyatt, Jalin
WR Slayton, Darius
WR Robinson, Wan'Dale
TE Johnson, Theo
QB Dart, Jaxson
RB Tracy Jr., Tyrone
Statistical Leaders
San Francisco 49ers
Passing: Mac Jones (1,597)
Rushing: Christian McCaffrey (490)
Receiving: Christian McCaffrey (559)
Touchdowns: Christian McCaffrey (6)
New York Giants
Passing: Jaxson Dart (984)
Rushing: Cam Skattebo (410)
Receiving: Wan'Dale Robinson (494)
Touchdowns: Cam Skattebo (7)
Coaches:
San Francisco 49ers: Kyle Shanahan (9th season)
New York Giants: Brian Daboll (4th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
