by Rod Pearson
Tuesday, Sep 12, 2023
Game Time: 4:05 pm ET, Sunday, September 17, 2023
Venue: SoFi Stadium, Inglewood, CA
Where to Watch: FOX
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: 49ers -8, Rams +8; Over/Under: 44.5 points
Bet365: Point Spread: 49ers -8, Rams +8; Over/Under: 44.5 points
BetMGM: Point Spread: 49ers -8.5, Rams +8.5; Over/Under: 44.5 points
Season Record
San Francisco 49ers: 1-0 (2nd place, NFC West)
Los Angeles Rams: 1-0 (1st place, NFC West)
Do not miss out on our expert handicapper analysis! Al McMordie has been CRUSHING THE NFL with 11 Straight Winning NFL Seasons! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.
Recent Form
San Francisco 49ers: won their last game on the road against the Pittsburgh Steelers 30-7.
Los Angeles Rams: won their last game on the road against the Seattle Seahawks 30-13.
San Francisco 49ers vs Los Angeles Rams Preview and Analysis
The 49ers are entering this game with a 1-0 record overall and they have a 0-0 record in their divisional games too. They are 0-0 in their home games, 1-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Pittsburgh Steelers 30-7. Brock Purdy was the starting QB and he completed 19/29 passes for 220 passing yards, 2 touchdowns, and 0 interceptions. Christian McCaffrey led the team in rushing yards with 152 and 1 TD. Brandon Aiyuk led the receivers with 129 receiving yards on 8 receptions and 2 TDs. Deommodore Lenoir led the defense in that game with 8 solo tackles and 2 assisted tackles while Drake Jackson led the defense in sacks with 2. Talanoa Hufanga and Charvarius Ward each came away with 1 interception in that game.
The Rams are entering this game with a 1-0 record overall and they have a 1-0 record in their divisional games too. They are 0-0 in their home games, 1-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the Seattle Seahawks 30-13. Matthew Stafford was the starting QB and he completed 24/38 passes for 334 passing yards, 0 touchdowns, and 0 interceptions. Kyren Williams led the team in rushing yards with 52 and 2 TDs. Puka Nacua led the receivers with 119 receiving yards on 10 receptions. Ernest Jones led the defense in that game with 4 solo tackles and 5 assisted tackles while Byron Young, Aaron Donald, Michael Hoecht, and Kobie Turner each led the defense in sacks with 0.5. No one on the defense came away with an interception in that game.
49ers vs Rams Prediction
The current betting odds have the 49ers listed as an 8 point favorite in this game according to Draftkings Sportsbook. The 49ers crushed the Steelers on the road in their season opener and the 49ers have a Super Bowl roster this year from top to bottom. The Rams also looked really good in their season opener as they beat a division rival on the road but they were also playing a Seahawks team that is likely going to take a step back this season. Stafford played well in that game but the Rams are still lacking a lot of talent on their offense and they have always struggled against the 49ers over the last few years, including getting swept by them in the regular season the year the Rams won the Super Bowl. The 49ers are on the road here but they have one of the best offenses in the NFL along with one of the best defenses and they are going to show the Rams in this game why the NFC West is still their division to take. The best way to place a bet here is on the 49ers to cover the spread in this game.
49ers Rams Prediction: Our NFL Pick for Sunday, September 17, 2023 (4:05 pm ET start time) is 49ers 27 Rams 14.
Don't miss our champion handicappers free picks and expert football picks today. And if you enjoyed this San Francisco 49ers Los Angeles Rams prediction, be sure to drop by every day for our weekly NFL predictions and previews.
NFL Betting Trends
San Francisco 49ers: 26-15 ATS in all games. 20-12 ATS as a favorite. 21-9 ATS against conference opponents. 14-7 UNDER in road games. 10-4 UNDER in a road game where the total is between 42.5 and 49 points.
Los Angeles Rams: 25-44 ATS in a home game where the total is between 42.5 and 45 points. 1-7 ATS after gaining 300 or more passing yards in the last game. 8-4 UNDER off a division game. 6-2 UNDER off a road win.
Key Injuries
San Francisco 49ers: R. Beal Jr. (DL) Out indefinitely - Hamstring. D. Gray (WR) Out indefinitely - Shoulder. D. Luter Jr. (CB) Out indefinitely - Knee. C. Latu (TE) I-R - Knee. R. McCloud III (WR) Early Oct - Wrist.
Los Angeles Rams: S. Bennett (QB) Ques Sun - Shoulder. H. Long (TE) Out indefinitely - Thigh. C. Kupp (WR) Out indefinitely - Hamstring. O. Mathis (LB) Out indefinitely - Knee.
Notable Quotes
“When you've got wide receivers that block like that, it’s a special feeling for a running back because you know and truly feel like your guys have your back.” - Christian McCaffrey after their win against the Steelers in their last game.
″I couldn’t care less what’s said outside. There might be some change in narratives and that doesn’t affect any way that we’ll go about our business right now.” - Sean McVay after his team’s win against the Seahawks in their last game.
Starting Lineups
San Francisco 49ers
WR Aiyuk, Brandon
WR Samuel, Deebo
WR Jennings, Jauan
TE Kittle, George
QB Purdy, Brock
RB McCaffrey, Christian
FB JUSZCZYK, KYLE
Los Angeles Rams
WR Jefferson, Van
WR Nacua, Puka
WR Atwell, Tutu
TE HIGBEE, TYLER
QB STAFFORD, MATTHEW
RB Akers, Cam
Statistical Leaders
San Francisco 49ers
Passing: B. Purdy (220)
Rushing: C. McCaffrey (152)
Receiving: B. Aiyuk (129)
Touchdowns: B. Aiyuk (2)
Los Angeles Rams
Passing: M. Stafford (334)
Rushing: K. Williams (52)
Receiving: T. Atwell (119)
Touchdowns: K. Williams (2)
Coaches:
San Francisco 49ers: Kyle Shanahan (7th season)
Los Angeles Rams: Sean McVay (7th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
