San Francisco 49ers vs Jacksonville Jaguars Prediction, Preview and Odds - 11/21/2021

by Amedeus Mastrangelo

Game Time: 1:00 pm ET, Sunday, November 21, 2021
Venue:  TIAA Bank Field, Jacksonville, FL
Where to Watch:  Fox

 

Opening Odds at USA Sportsbooks

DraftKings:  Point Spread:  49ers -6.5, Jaguars +6.5; Over/Under:  45 points
Bet365:  Point Spread:  49ers -6.5, Jaguars +6.5; Over/Under:  45.5 points
BetMGM:  Point Spread:  49ers -6.5, Jaguars +6.5; Over/Under:  45.5 points
 

Season Record

San Francisco 49ers:  4-5 (3rd place, NFC West)
Jacksonville Jaguars:  2-7 (3rd place, AFC South)
 
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San Francisco 49ers vs Jacksonville Jaguars Preview and Analysis

 
Recent Form
San Francisco 49ers:  won at home on Nov. 15 against the Los Angeles Rams 31-10.
Jacksonville Jaguars:  lost on the road on Nov. 14 against the Indianapolis Colts 23-17.
 
 
 

San Francisco 49ers Analysis

The 49ers are coming into this game with a 4-5 record overall and they are 3-1 in their road games this season where they will be in this game. They have won 2 of their last 3 games and are coming into this one off of a win in their last game. Jimmy Garoppolo played well in that game as he completed 15/19 passes for 182 yards and 2 touchdowns. Eli Mitchell led the team in rushing with 91 yards on 27 carries while Deebo Samuel ran in 1 TD on the ground in that one. Samuel also led the receivers with 97 yards and 1 touchdown on 5 receptions while George Kittle was right behind with 50 yards and 1 touchdown on 5 receptions. Azeez Al-Shaair led the defense in that game with 6 solo tackles and 2 assisted ones. Arden Key and Nick Bosa both recorded the only sacks in that game with 1 each while Jimmie Ward came away with 2 interceptions himself for them in that one. They have scored 216 points in their 9 games this season averaging 24 PPG and they have allowed their opponents to score 212 points against them allowing 23.6 PPG. Their offense is averaging 362.2 YPG while their defense is allowing 331.4 YPG.
 
 

Jacksonville Jaguars Analysis

The Jaguars are coming into this game with a 2-7 record overall and they are 2-3 in their home games this season where they will be in this game. They have lost 2 of their last 3 games and they are coming into this one off of another loss in their last game. Trevor Lawrence was alright in that game but was nothing special as he completed 16/35 passes for 162 yards. Jamal Agnew led the team in rushing with 79 yards and 1 touchdown on 3 carries while James Robinson had 57 yards and 1 touchdown on 12 carries. Dan Arnold led the receivers with 67 total yards on 5 receptions while Marvin Jones had 35 yards on 2 receptions. Rayshawn Jenkins led the defense in that game with 4 solo tackles and 2 assisted ones. Davon Hamilton recorded the only sack in that game for them while no one on the defense was able to come up with an interception for them in that one. They have scored 149 points in their 9 games this season averaging 16.6 PPG and they have allowed their opponents to score 232 points against them allowing 25.8 PPG. Their offense is averaging 332.7 YPG while their defense is allowing 366.4 YPG.
 
 

 

49ers vs Jaguars Prediction

The SF 49ers are coming into this matchup as a 6.5 point favorite with the current betting odds according to Draftkings Sportsbook. The 49ers played very well in their last game and will be looking to carry that over into this next game. The Jags have been getting better in recent games but it is their defense that is keeping them in their games, the offense is still a mess and is not scoring a lot of points in their games. The 49ers have a much better coach and more talent on their team, they should be able to carry over what they did in their last game into the next one as they finally looked like the team that everyone thought they would be at the beginning of the season. The best bet to place in this game is on the 49ers to cover the spread here.
 
49ers Jaguars Prediction:  Our NFL Pick for Sunday, November 21, 2021 (1:00 pm ET start time) is 49ers 35 Jaguars 14.
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NFL Betting Trends

 
San Francisco 49ers: 76-72 ATS as a favorite of 3.5 to 9.5 points. 138-134 ATS as a favorite. 52-45 ATS as a road favorite. 38-26 ATS as a road favorite of 7 points or less. 62-49 ATS in a road game where the total is between 42.5 and 49 points. 90-83 ATS off a division game.
Jacksonville Jaguars: 66-69 ATS as an underdog of 3.5 to 9.5 points. 204-220 ATS in all games. 126-131 ATS as an underdog. 41-50 ATS as a home underdog. 96-107 ATS in home games. 7-19 ATS against NFC West division opponents.
 

Key Injuries

 
San Francisco 49ers:  D. Samuel (WR) Ques Sun - Shin injury. J. Moore (OL) Ques Sun - Knee injury. E. Mitchell (RB) Ques Sun - Finger injury.
Jacksonville Jaguars:  D. Allen (LB) Ques Sun - Shoulder injury. J. Tufele (DT) Out indefinitely - Hand injury. A. Cann (OL) I-R - Knee injury.
 

Notable Quotes

 
"It got us into a rhythm for sure. That's the way we want to do it. Just running the ball, converting on third down and then score at the end. I don't want to say it took their soul away but it definitely did something." - Jimmy Garoppolo on their opening drive in their win against the Rams.
 
 
"I just have to take care of the ball. That just stings when you end the game that way. I'm disappointed with myself and frustrated." - Trevor Lawrence on getting strip-sacked on their last drive of their game against the Colts.
 
 

Starting Lineups

 
San Francisco 49ers
WR Brandon Aiyuk 
WR Samuel, Deebo 
TE Kittle, George
QB Garoppolo, Jimmy 
RB Elijah Mitchell
RB Sermon, Trey 
FB JUSZCZYK, KYLE 
 
Jacksonville Jaguars
WR Treadwell, Laquon
WR JONES, MARVIN 
WR Shenault Jr., Laviska 
TE Manhertz, Chris 
TE Hollister, Jacob 
QB Lawrence, Trevor 
RB Robinson, James 
 

Statistical Leaders

 
San Francisco 49ers
Passing: J. Garoppolo (1936)
Rushing: E. Mitchell (560)
Receiving: D. Samuel (979)
Touchdowns: D. Samuel (5)
 
Jacksonville Jaguars
Passing: T. Lawrence (1983)
Rushing: J. Robinson (539)
Receiving: M. Jones Jr. (434)
Touchdowns: J. Robinson (6)
 
Coaches:
San Francisco 49ers: Kyle Shanahan (5th season)
Jacksonville Jaguars: Urban Meyer (1st season)


Amedeus Mastrangelo

About the Author:

Amedeus Mastrangelo has been heavily wagering on all sports for years and plays just about everything, including sides, totals, favorites, underdogs, against the spread, alternative spreads, first half, second half, player props, and futures. The bottom line is, if Mastrangelo can see an edge in any way shape or form, then he's going to take advantage.

All photographic images used for editorial content have been licensed from the Associated Press.

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