San Diego Padres vs San Francisco Giants Prediction, Preview and Odds - 06/21/2023

by Rod Pearson

Wednesday, Jun 21, 2023
Game Time: 9:45 pm ET, Wednesday, June 21, 2023
Venue:  Oracle Park, San Francisco, CA
Where to Watch:  NBCS-BA


Opening Odds at USA Sportsbooks

DraftKings:  Moneyline odds:  Padres -120, Giants +100; Over/Under:  8 runs
Bet365:  Moneyline odds:  Padres -120, Giants +100; Over/Under:  8 runs
BetMGM:  Moneyline odds:  Padres -120, Giants +100; Over/Under:  8 runs

Season Record

San Diego Padres:  35-37 (4th place, NL West)
San Francisco Giants:  40-32 (2nd place, NL West)

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Recent Form
San Diego Padres:  6-4 last 10
San Francisco Giants:  8-2 last 10



San Diego Padres vs San Francisco Giants Preview and Analysis


The Padres are entering this game off of a loss in their last game but won their 3-game series against the Tampa Bay Rays 2-1 in their last series. They enter this game with a 35-37 record overall and have a road record of 16-17. This is the 3rd game of a 4-game series with the Giants on Wednesday with the 2nd game of this series still to be played on Tuesday. Their offense ranks 19th in the MLB with a .713 OPS. Seth Lugo is their starting pitcher on Tuesday while Yu Darvish is making his start in this game on Wednesday. He is 5-5 with a 4.74 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 6 ER, 2 HR, and 1 BB with 5 Ks on 8 hits through 5 IP against the Tampa Bay Rays.

The Giants are entering this game on an 8 game winning streak and completed the sweep 3-0 in their 3-game series against the Los Angeles Dodgers in their last series. They enter this game with a 40-32 record overall and have a home record of 19-17. This is the 3rd game of a 4-game series with the Padres on Wednesday with the 2nd game of this series still to be played on Tuesday. Their offense ranks 7th in the MLB with a .753 OPS. Anthony DeSclafani is their starting pitcher on Tuesday while rookie pitcher Ryan Walker is making his start in this game on Wednesday. He is 2-0 with a 1.65 ERA this season. His team won their last 4 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 1 homer, and 1 BB with 0 strikeouts on 3 hits through 1.2 innings played against the San Diego Padres.


Padres vs Giants Prediction

The current betting odds have the Giants listed as a slight underdog in this game according to Draftkings Sportsbook. The Giants have been on a roll lately with their 8 game win streak and their offense has been rolling too. They just swept their division rival Dodgers in their last series and they are coming for another sweep of a division rival in this series. They have already taken the 1st game of this series and their offense is just going to keep rolling like it has been in their last few games. Darvish is on the mound for the Giants in this game but he just gave up 6 earned runs in his last start and he hasn't been having a good season either. With the way the Giants have been putting up runs in their games lately, they are going to get after Darvish for some runs with how bad he has been lately and the Giants will be looking to keep this big run going at home here. The Padres haven't really had a good offense this season either so it is hard to see them keeping up here when the Giants pitching has been really good too. The Giants will keep on rolling here with this series being at home. The best way to place a bet here is on the Giants to win this game.

Padres Giants Prediction:  Our MLB Pick for Wednesday, June 21, 2023 (9:45 pm ET start time) is Giants 7 Padres 4.
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MLB Betting Trends


San Diego Padres: 35-37 (-13 units) on the moneyline in all games. 12-19 (-14.8 units) on the moneyline when the total is 8 to 8.5. YU DARVISH is 22-13 OVER against division opponents and 4-2 OVER in road games. 

San Francisco Giants: 18-9 (+12.5 units) on the moneyline as an underdog of +100 to +150. 23-15 (+7.9 units) on the moneyline in night games. 20-10 OVER as an underdog of +100 or higher. SEAN MANAEA is 14-4 OVER as an underdog of +100 or higher.

Key Injuries


San Diego Padres:  T. Cosgrove (RP) Out indefinitely - Hamstring. S. Lugo (RP) Late June - Calf. R. Suarez (SP) Late June - Arm. L. Campusano (C) Late July - Thumb. D. Pomeranz (RP) Out indefinitely - Forearm. E. Rosario (3B) Mid July - Ankle.

San Francisco Giants:  S. Alexander (RP) Out indefinitely - Hamstring. A. Cobb (SP) Early July - Oblique. W. Flores (1B) Out indefinitely - Foot. J. Brebbia (RP) Out indefinitely - Back. M. Haniger (RF) Late Aug - Forearm. R. Stripling (SP) Late June - Back. H. Ramos (LF) Late July - Oblique. T. Szapucki (SP) out for season - Arm. R. Perez (C) out for season - Shoulder. L. Gonzalez (CF) Mid July - Back.


Notable Quotes


“He's eager to get back out there.” - Bob Melvin on the potential return of Seth Lugo after his team’s loss against the Giants in their game on Monday.


“It was an incredible battle from a fan's perspective. It was excellent to watch.” - Gabe Kapler after his team’s win against the Padres in their game on Monday.


Starting Lineups


San Diego Padres
Fernando Tatis Jr. (R) RF
Juan Soto (L) LF
Manny Machado (R) 3B
Xander Bogaerts (R) SS
Jake Cronenworth (L) 1B
Gary Sanchez (R) C
Rougned Odor (L) DH
Ha-Seong Kim (R) 2B
Trent Grisham (L) CF

San Francisco Giants
LaMonte Wade Jr. (L) 1B
Joc Pederson (L) DH
Thairo Estrada (R) 2B
Michael Conforto (L) LF
Mike Yastrzemski (L) RF
Luis Matos (R) CF
Brandon Crawford (L) SS
Patrick Bailey (S) C
David Villar (R) 3B

Statistical Leaders


San Diego Padres
Batting Average:  Alfonso Rivas (.286)
Hits:  Xander Bogaerts (65)
Home Runs:  Fernando Tatis (14)
RBI:  Juan Soto (36)
Stolen Bases:  Ha-Seong Kim (12)
Wins:  Michael Wacha (7)
Saves:  Josh Hader (18)
ERA:  Tom Cosgrove (0.53)

San Francisco Giants
Batting Average:  Austin Slater (.431)
Hits:  Thairo Estrada (72)
Home Runs:  Michael Conforto (12)
RBI:  J.D. Davis (40)
Stolen Bases:  Thairo Estrada (17)
Wins:  Logan Webb (6)
Saves:  Camilo Doval (19)
ERA:  Luke Jackson (1.23)

Managers:
San Diego Padres: Bob Melvin (2nd season)
San Francisco Giants: Gabe Kapler (4th season)


Rod Pearson

About the Author:

Rod Pearson has been a rabid sports fan his entire life.  He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years.  In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective.  Join Rod every day as he breaks down the games to find the best betting value.

All photographic images used for editorial content have been licensed from the Associated Press.

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