Game Time: 3:45 pm ET, Thursday, June 5, 2025
Venue: Oracle Park, San Francisco, CA
Where to Watch: NBCS-BA
Opening Odds at USA Sportsbooks
DraftKings: Moneyline odds: Padres +102, Giants -122; Over/Under: 7 runs
Bet365: Moneyline odds: Padres +100, Giants -120; Over/Under: 7 runs
BetMGM: Moneyline odds: Padres +100, Giants -120; Over/Under: 7 runs
Season Record
San Diego Padres: 35-24 (2nd place, NL West)
San Francisco Giants: 33-28 (3rd place, NL West)
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Recent Form
San Diego Padres: 7-3 last 10
San Francisco Giants: 3-7 last 10
San Diego Padres vs San Francisco Giants Preview and Analysis
The Padres are entering this series off a win and won their 3-game series against the Pittsburgh Pirates 2-1 in their last series. They enter this game with a 35-24 record overall and have a road record of 15-14. This is the series finale of a 4-game series with the Giants on Thursday with the 3rd game still to be played on Wednesday. The Padres won the series opener of this series on Monday and the 2nd game on Tuesday. Their offense ranks 19th in the MLB with a .695 OPS. Nick Pivetta is their starting pitcher on Wednesday while Dylan Cease is making his start in this game on Thursday. He is 1-4 with a 4.66 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 3 ER, 1 HR, and 1 BB with 6 Ks on 7 hits through 4.2 IP against the Pittsburgh Pirates.
The Giants are entering this series off a win and won their 3-game series against the Miami Marlins 2-1 in their last series. They enter this game with a 33-28 record overall and have a home record of 17-11. This is the 4th game of a 4-game series with the Padres on Thursday with the 3rd game of this series still to be played on Wednesday. The Giants lost the 1st game of this series on Monday and the 2nd game on Tuesday. Their offense ranks 24th in the MLB with a .679 OPS. Kyle Harrison is their starting pitcher on Wednesday while Robbie Ray is making his start in this game on Thursday. He is 7-1 with a 2.43 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 0 homers, and 3 BB with 9 strikeouts on 2 hits through 7 innings played against the Miami Marlins.
Padres vs Giants Prediction
The current betting odds have the Giants listed as a slight favorite in this game according to Draftkings Sportsbook. The Giants have looked good in their games this season with their 33-28 record overall which has them right in the middle of the NL West and in the Wild Card race. They have looked a lot better in their own ballpark this year with their 17-11 home record too. Meanwhile, the Padres have looked good in their games this season with their 35-24 record overall which has them right near the top of the NL West. They haven't been a great road team this season though with their 15-14 road record. The Padres have been the much hotter team lately, going 7-3 in their last 10 games while the Giants are 3-7 and have been in a slump, but the Giants do have the better pitching matchup here and can use that to break out of this slump. Ray is on the mound for the Giants in this one and he has been lights out for them all season. He is 7-1 with a 2.43 ERA and he hasn't been giving up many runs in any of his starts this year. He is coming off a great start in which he only gave up 1 earned run and he will be looking to repeat that great performance here. Cease is on the mound for the Padres here and he has been so good throughout his career, but he hasn't been having a good season this year. He is 1-4 with a 4.86 ERA and has been giving up a lot more runs in his starts. He gave up 3 earned runs in his last start which has been a common theme for him this year, and the team has lost 2 of their last 3 games with him starting too. The Giants haven't looked good lately but they can take advantage of this pitching matchup since the Padres haven't been at their best in road games this season. The best way to place a bet here is on the Giants to win this game.
Padres Giants Prediction: Our MLB Pick for Thursday, June 5, 2025 (3:45 pm ET start time) is Giants 5 Padres 2.
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MLB Betting Trends
San Diego Padres: 75-47 (+8.9 units) on the moneyline vs. a team slugging percentage .400 or worse on the season (NL). 76-60 (+19.4 units) on the moneyline vs. teams outscoring opp by 0.5 or more runs/game on the season. 24-18 (+7.3 units) on the moneyline vs. NL teams allowing 4.0 or less runs/game on the season. 35-22 UNDER vs. a team with a good bullpen whose ERA is 3.45 or better.
San Francisco Giants: 192-192 (-20.6 units) on the moneyline in all games. 105-131 (-32.8 units) on the moneyline vs. a team with a good bullpen whose WHIP is 1.350 or better. 84-101 (-11.8 units) on the moneyline when playing against a team with a winning record. 29-12 UNDER at home when playing against a good team (Win Pct. 54% to 62%).
Key Injuries
San Diego Padres: M. King (SP) Fifteen Day IL - Shoulder. J. Heyward (LF) Ten Day IL - Oblique. M. McCoy (SS) Ten Day IL - Finger. L. Gillaspie (RP) Fifteen Day IL - Oblique. B. Hoeing (RP) Sixty Day IL - Shoulder. J. Brito (RP) Sixty Day IL - Forearm. Y. Darvish (SP) Fifteen Day IL - Elbow. J. Musgrove (SP) Sixty Day IL - Elbow.
San Francisco Giants: J. Hicks (SP) Fifteen Day IL - Toe. L. Wade Jr. (1B) Day To Day - Hand. J. Verlander (SP) Fifteen Day IL - Pectoral. T. Murphy (C) Sixty Day IL - Back.
Notable Quotes
"When he’s in a good spot, [he’s] got that nice easy stroke going, putting a good swing on the baseball. When he does that consistently -- watch out.” - Mike Shildt after his team’s win against the Giants in their game on Tuesday.
“I think [it’s] the natural progression, just to challenge him more, see some different pitching. He’ll probably be attacked differently in the next league up. I look forward to seeing him continue to progress.” - Buster Posey on Bryce Eldridge developing.
Starting Lineups
San Diego Padres
Fernando Tatis Jr. (R) RF
Luis Arraez (L) 1B
Manny Machado (R) 3B
Jackson Merrill (L) CF
Gavin Sheets (L) DH
Xander Bogaerts (R) SS
Jake Cronenworth (L) 2B
Tyler Wade (L) LF
Martín Maldonado (R) C
San Francisco Giants
Heliot Ramos (R) LF
Jung Hoo Lee (L) CF
Wilmer Flores (R) DH
Matt Chapman (R) 3B
Willy Adames (R) SS
Jerar Encarnacion (R) RF
Tyler Fitzgerald (R) 2B
Patrick Bailey (S) C
Casey Schmitt (R) 1B
Statistical Leaders
San Diego Padres
Batting Average: Jackson Merrill (.323)
Hits: Manny Machado (69)
Home Runs: Fernando Tatis (13)
RBI: Gavin Sheets (34)
Stolen Bases: Xander Bogaerts (11)
Wins: Nick Pivetta (6)
Saves: Robert Suarez (19)
ERA: Bradgley Rodriguez (0.00)
San Francisco Giants
Batting Average: Heliot Ramos (.293)
Hits: Heliot Ramos (67)
Home Runs: Heliot Ramos (11)
RBI: Wilmer Flores (47)
Stolen Bases: Tyler Fitzgerald (8)
Wins: Robbie Ray (7)
Saves: Ryan Walker (10)
ERA: Randy Rodríguez (0.68)
Managers:
San Diego Padres: Mike Shildt (2nd season)
San Francisco Giants: Bob Melvin (2nd season)