San Diego Padres vs Cleveland Guardians Prediction, Preview and Odds - 08/14/2026

Game Time: 7:10 pm ET, Friday, August 14, 2026

Venue:  Progressive Field, Cleveland, OH

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Padres +109, Guardians -131; Over/Under:  7 runs

Bet365:  Moneyline odds:  Padres +110, Guardians -130; Over/Under:  7.5 runs

BetMGM:  Moneyline odds:  Padres +110, Guardians -135; Over/Under:  7.5 runs

San Diego Padres:  65-57 (2nd place, NL West)

Cleveland Guardians:  59-62 (4th place, AL Central)

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San Diego Padres:  7-3 last 10

Cleveland Guardians:  3-7 last 10

The Padres are entering this series off a win and completed the sweep in their 3-game series against the Milwaukee Brewers 3-0 in their last series. They enter this game with a 65-57 record overall and have a road record of 28-31. This is the series opener of a 3-game series with the Guardians on Friday and they have Thursday off as a day of rest. Their offense ranks 24th in the MLB with a .702 OPS. Robbie Ray was their starting pitcher on Wednesday while Michael King is making his start in this game on Friday. He is 7-8 with a 3.37 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season appearance, he allowed 1 ER, 1 HR, and 1 BB with 6 SO on 3 hits through 6 IP against the Houston Astros.

The Guardians are entering this series off a loss and lost their 3-game series against the Detroit Tigers 2-1 in their last series. They enter this game with a 59-63 record overall and have a home record of 28-31. This is the 1st game of a 3-game series with the Padres on Friday. Their offense ranks 29th in the MLB with a .682 OPS. Parker Messick was their starting pitcher on Thursday while Gavin Williams is making his start in this game on Friday. He is 11-6 with a 3.55 ERA this season. His team lost 4 of their last 5 games this season with him making an appearance. In his last MLB regular season start, he allowed 2 earned runs, 1 homer, and 2 walks with 7 strikeouts on 3 hits through 5.2 innings pitched against the Chicago White Sox.

The current betting odds have the Padres listed as an underdog in this game according to Draftkings Sportsbook. The Padres have looked good in their games this season with their 65-57 record overall which has them right near the top of the NL West. They haven't been a great road team though with their 28-31 road record this year. Meanwhile, the Guardians haven't looked great in their games this season with their 59-63 record overall which has them right near the bottom of the AL Central. They haven't looked great in their own ballpark either with their 28-31 home record this season. The Guardians were right in the race for the division and still are, but lately they have been sliding down the standings. They have been in a big slump, now 3-7 in their last 10 games, and they have one of the worst offenses in MLB too. The Padres have been rolling though, now 7-3 in their last 10 games, and their offense has looked a lot better over the last week. The Padres are going with King in this one and he has looked good this season. He is 7-8 with a 3.37 ERA and he hasn't been giving up many runs lately. He is coming off another great start giving up 1 earned run which has been a common theme for him and the team has been having more success with him lately, winning 2 of their last 3 games with him starting. The Guardians are going with Williams in this one and he has looked good this year. He is 11-6 with a 3.55 ERA, but lately the team has had a lot of trouble with him. He only gave up 2 earned runs in his last start, but the team has lost 4 of their last 5 games with him starting and the bullpen has been giving up a lot more runs too. Look for the Padres to take advantage of this pitching matchup and stay hot against a slumping Guardians team with no offense. The best way to place a bet here is on the Padres to win this game. 

Padres Guardians Prediction:  Our MLB Pick for Friday, August 14, 2026 (7:10 pm ET start time) is Padres 3 Guardians 2.

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San Diego Padres: 254-203 (+29.5 units) on the moneyline in all games. 117-111 (+12.7 units) on the moneyline in road games. 98-92 (+31.2 units) on the moneyline as an underdog of +100 or higher. 34-20 UNDER on the road when the total is 7 to 7.5.

Cleveland Guardians: 14-22 (-9.1 units) on the moneyline against NL West opponents. 63-70 (-8.1 units) on the moneyline in an inter-league game. 18-30 (-10.3 units) on the moneyline vs. an NL starting pitcher whose WHIP is 1.250 or better. 31-17 UNDER vs. an NL starting pitcher whose WHIP is 1.250 or better.

San Diego Padres:  M. Andujar (DH) Ten Day IL - Wrist. S. Taylor (LF) Ten Day IL - Oblique. J. Adam (RP) Sixty Day IL - Shoulder. L. Giolito (SP) Fifteen Day IL - Elbow. R. Laureano (LF) Sixty Day IL - Hip. N. Pivetta (SP) Sixty Day IL - Elbow. B. Hoeing (RP) Sixty Day IL - Elbow. J. Musgrove (SP) Sixty Day IL - Elbow.

Cleveland Guardians:  S. Cecconi (SP) Fifteen Day IL - Arm. S. Armstrong (RP) Sixty Day IL - Leg.

“It’s actually invigorated us. It’s shown us we can handle anything.” - Craig Stammen after his team’s win against the Brewers in their game on Wednesday.

“They made him work. Tip your cap to them. Great at-bats.” - Stephen Vogt after his team’s win against the Tigers in their game on Wednesday. 

Luis Rengifo (S) LF

Jake Cronenworth (L) 2B

Manny Machado (R) 3B

Ty France (R) 1B

Jackson Merrill (L) CF

Austin Hays (R) RF

Gavin Sheets (L) DH

Xander Bogaerts (R) SS

Freddy Fermin (R) C

Steven Kwan (L) CF

Chase DeLauter (L) RF

José Ramírez (S) DH

Nathaniel Lowe (L) 1B

Jo Adell (R) LF

Travis Bazzana (L) 2B

Angel Genao (S) 3B

Austin Hedges (R) C

Brayan Rocchio (S) SS

Batting Average:  Austin Hays (.333)

Hits:  Fernando Tatis (131)

Home Runs:  Manny Machado (23)

RBI:  Manny Machado (70)

Stolen Bases:  Fernando Tatis (28)

Wins:  Adrian Morejon (9)

Saves:  Mason Miller (30)

ERA:  Mason Miller (0.88)

Batting Average:  Angel Genao (.308)

Hits:  Chase DeLauter (111)

Home Runs:  Kyle Manzardo (13)

RBI:  Chase DeLauter (57)

Stolen Bases:  José Ramírez (29)

Wins:  Gavin Williams (11)

Saves:  Cade Smith (31)

ERA:  Colin Holderman (2.08)

Managers:

San Diego Padres: Craig Stammen (1st season)

Cleveland Guardians: Stephen Vogt (3rd season)