by Rod Pearson
Tuesday, Nov 04, 2025
Game Time: 10:00 pm ET, Wednesday, November 5, 2025
Venue: Crypto.com Arena, Los Angeles, CA
Where to Watch: ESPN
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Spurs +2.5, Lakers -2.5; Over/Under: 230.5 points
Bet365: Point Spread: Spurs +2.5, Lakers -2.5; Over/Under: 230.5 points
BetMGM: Point Spread: Spurs +2.5, Lakers -2.5; Over/Under: 230.5 points
Season Record
San Antonio Spurs: 5-1 (1st place, Southwest Division)
Los Angeles Lakers: 6-2 (1st place, Pacific Division)
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Recent Form
San Antonio Spurs: 5-1 last 6
Los Angeles Lakers: 6-2 last 8
San Antonio Spurs vs Los Angeles Lakers Preview and Analysis
The Spurs are entering this game with a 5-1 record overall this season and they are 2-1 in their road games this season where they will be in this game. They are entering this game off a loss against the Phoenix Suns. Stephon Castle led the team in points in that game with 26 while Keldon Johnson was next on the team with 19 points. Stephon Castle led the team in assists in that game with 5 while Victor Wembanyama led the team in rebounds with 9. They were 45.9% from the field, 24.4% from 3-point range, and 78.3% from the free throw line with their shots in that game. Their offense is averaging 118.2 PPG and their defense is allowing their opponents to average 108.2 PPG against them. The Spurs have an ATS record of 3-1-2 this season and their O/U record is 2-4.
The Lakers are entering this game with a 6-2 record overall this season and they are 2-2 in their home games this season where they will be in this game. They are entering this game on a 4 game winning streak with wins coming against the Minnesota Timberwolves, the Memphis Grizzlies, the Miami Heat, and the Portland Trail Blazers. Deandre Ayton led the team in points in that game with 29 while Rui Hachimura was next on the team with 28 points. Jake LaRavia, Nick Smith Jr., and Bronny James each led the team in assists in that game with 6 while Deandre Ayton led the team in rebounds with 10. They were 58.8% from the field, 39.1% from 3-point range, and 87.5% from the free throw line with their shots in that game. Their offense is averaging 119.8 PPG and their defense is allowing their opponents to average 116.6 PPG against them. The Lakers have an ATS record of 6-2 this season and their O/U record is 7-1.
Spurs vs Lakers Prediction
The current betting odds have the Spurs listed as a 2.5 point underdog in this game according to Draftkings Sportsbook. The Lakers have looked really good in their games this season with their 6-2 record overall which has them right near the top of the West with one of the best records in the NBA. They haven't looked great on their home court though with their 2-2 home record this season. Meanwhile, the Spurs have looked great in their games this season with their 5-1 record overall which has them right near the top of the West with one of the best records in the NBA. They have been a good road team too with their 2-1 road record so far. They were really hot to start the season with 5 wins in a row, but now they are off their first loss of the season. They are coming off a big loss on the road to the Suns and didn't look great in that one, but they will be looking to bounce back. The Lakers have been rolling lately with 4 wins in a row now and they are off a road win over the Trail Blazers in their last one, but they have also been getting by with a lot of injuries so far. They managed to beat the Trail Blazers on the road while missing some key players like LeBron, Luka, and Reaves, but that isn't going to be sustainable for them. Now they come back home where they haven't looked as good this year and could be missing those key players again while the Spurs have been rolling all year and will be looking to bounce back after their first loss of the season. The best way to place a bet here is on the Spurs to cover the spread in this game.
Spurs Lakers Prediction: Our NBA Pick for Wednesday, November 5, 2025 (10:00 pm ET start time) is Spurs 129 Lakers 121.
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NBA Betting Trends
San Antonio Spurs: 35-22 ATS off a road loss. 14-4 ATS when playing against a top-level team (Win Pct. > 70%). 31-20 ATS versus good teams - outscoring their opponents by 3+ points/game. 21-14 OVER against Pacific division opponents. 37-20 OVER off a road loss.
Los Angeles Lakers: 16-25 ATS off a road win. 3-6 ATS at home off an upset win as a road underdog. 22-14 OVER against Southwest division opponents. 21-14 OVER off an upset win as an underdog. 12-7 OVER versus teams who average 9 or more steals/game on the season.
Key Injuries
San Antonio Spurs: D. Harper (SG) Out - Calf. L. Kornet (C) Day To Day - Ankle. K. Olynyk (C) Day To Day - Heel. L. Waters III (SG) Day To Day - Eye. D. Fox (PG) Day To Day - Hamstring. J. Sochan (PF) Day To Day - Wrist.
Los Angeles Lakers: A. Reaves (SG) Day To Day - Groin. L. Doncic (PG) Day To Day - Leg. M. Kleber (PF) Day To Day - Oblique. G. Vincent (PG) Out - Ankle. A. Thiero (SF) Out - Knee. L. James (SF) Out - Nerve.
Notable Quotes
“We've seen great things from him.” - Victor Wembanyama on Dylan Harper this season.
“You can’t win in the NBA without stepping on the floor and expecting to win. And I thought our guys had that from the start.” - JJ Redick after his team’s win against the Trail Blazers in their game on Monday.
Starting Lineups
San Antonio Spurs
PG Jordan McLaughlin
SG Stephon Castle
SF Devin Vassell
PF Harrison Barnes
C Victor Wembanyama
Los Angeles Lakers
PG Luka Doncic
SG Austin Reaves
SF Marcus Smart
PF Rui Hachimura
C Deandre Ayton
Statistical Leaders
San Antonio Spurs
PPG: Victor Wembanyama (26.7)
APG: Stephon Castle (5.3)
Reb/G: Victor Wembanyama (13.7)
Los Angeles Lakers
PPG: Luka Doncic (41.3)
APG: Austin Reaves (9.3)
Reb/G: Luka Doncic (11.5)
Coaches:
San Antonio Spurs: Mitch Johnson (2nd season)
Los Angeles Lakers: JJ Redick (2nd season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
