Rutgers Scarlet Knights vs Ohio State Buckeyes Prediction, Picks and Game Preview - 11/22/2025

by Rod Pearson

Monday, Nov 17, 2025
Game Time: 12:00 pm ET, Saturday, November 22, 2025
Venue:  Ohio Stadium, Columbus, OH
Where to Watch:  FOX


Opening Odds at USA Sportsbooks

DraftKings:  Point Spread:  Rutgers +30.5, Ohio State -30.5; Over/Under:  56.5 points
Bet365:  Point Spread:  Rutgers +31.5, Ohio State -31.5; Over/Under:  56.5 points
BetMGM:  Point Spread:  Rutgers +30.5, Ohio State -30.5; Over/Under:  56.5 points

Season Record

Rutgers Scarlet Knights:  5-5 (2-5) (13th place, Big Ten)
Ohio State Buckeyes:  10-0 (7-0) (2nd place, Big Ten)

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Recent Form
Rutgers Scarlet Knights:  won their last game at home against the Maryland Terrapins 35-20.
Ohio State Buckeyes:  won their last game at home against the UCLA Bruins 48-10.


Rutgers Scarlet Knights vs Ohio State Buckeyes Preview and Analysis


Rutgers is entering this game with a 5-5 record overall and they have a 2-5 record in their conference games too. They are 4-2 in their home games, 1-3 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Maryland 35-20. Athan Kaliakmanis was the starting QB and he completed 13/20 passes for 229 passing yards, 4 touchdowns, and 2 interceptions. Antwan Raymond led the team in rushing yards with 240 and 1 TD. Ian Strong led the receivers with 88 receiving yards on 5 receptions and 3 TDs. Eric O'Neill led the defense in that game with 7 solo tackles and 3 assisted tackles while no one on the defense recorded a sack for them. Jett Elad came away with the only interception for them in that one.
 
 
 
Ohio State is entering this game with a 10-0 record overall and they have a 7-0 record in their conference games too. They are 6-0 in their home games, 4-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against UCLA 48-10. Julian Sayin was the starting QB and he completed 23/31 passes for 184 passing yards, 1 touchdown, and 0 interceptions. Bo Jackson led the team in rushing yards with 112 and 1 TD. Mylan Graham led the receivers with 40 receiving yards on 3 receptions. Sonny Styles led the defense in that game with 4 solo tackles and 3 assisted tackles while no one on the defense recorded a sack for them. No one on the defense came away with an interception for them in that one.


Rutgers vs Ohio State Prediction

The current betting odds have Ohio State listed as a 30.5 point favorite in this game according to Draftkings Sportsbook. Ohio State has looked great in their games this season with their 10-0 record overall and their 7-0 conference record which has them right near the top of the Big Ten. They have been rolling over teams all season and are currently ranked 1st overall. Meanwhile, Rutgers hasn't looked great in their games this season with their 5-5 record overall and their 2-5 conference record which has them right near the bottom of the Big Ten. They have struggled a lot in their conference schedule, but they are only 1 win away from bowl eligibility. Unfortunately for them, this isn't the game they want on their schedule, going on the road against the best team in the nation. They are off a 35-20 win over Maryland in their last one and now they are coming out of their bye week, but it isn't going to matter much in this one. Ohio State is off a 48-10 win over UCLA in their last one and they have been doing that to teams all season, their closest game all year being a 14-7 win over Texas in their season opener. They have one of the best defenses in the nation as they haven't been giving up many points all year, and their offense has been putting up a ton of points without even going 100% in their games. Rutgers is not at the same level as Ohio State so this is going to be another dominant win by the number 1 team in the nation. The best way to place a bet here is on Ohio State to cover the spread in this game. 

Rutgers Ohio State Prediction:  Our NCAAF Pick for Saturday, November 22, 2025 (12:00 pm ET start time) is Ohio State 42 Rutgers 3.
Don't miss our champion handicappers free picks and expert football picks today. And if you enjoyed this Rutgers Scarlet Knights Ohio State Buckeyes prediction, be sure to drop by every day for our weekly NCAAF predictions and previews.

NCAAF Betting Trends


Rutgers Scarlet Knights: 3-6 ATS versus good defensive teams - allowing 310 yards/game or less. 2-5 ATS when playing against a top-level team (Win Pct. > 75%). 4-7 ATS vs. good passing teams averaging 250 or more passing yards/game. 9-4 UNDER as a road underdog. 7-2 UNDER when playing against a top-level team (Win Pct. > 75%). 

Ohio State Buckeyes: 25-12 ATS in all lined games. 15-5 ATS as a home favorite. 18-8 ATS against conference opponents. 18-7 ATS after allowing 14 points or less last game. 24-15 UNDER in all lined games. 24-14 UNDER as a favorite.

Key Injuries


Rutgers Scarlet Knights:  D. Fuse (CB) Questionable - Undisclosed. M. Clayton (CB) Questionable - Undisclosed. V. Allen III (WR) Questionable - Undisclosed. D. DeNgohe (DL) Questionable - Undisclosed. D. Pardridge (WR) Questionable - Undisclosed. C. Joines (CB) Questionable - Undisclosed. J. Elijah (OG) Questionable - Undisclosed. B. Rothhaar (TE) Questionable - Undisclosed. A. Salaam (CB) Questionable - Undisclosed. J. Houston (WR) Questionable - Undisclosed. J. Walker (DL) Questionable - Undisclosed. M. Walker (LB) Out - Undisclosed. B. Kyle (DL) Out - Undisclosed. D. Chin (OG) Out - Undisclosed. N. Oliveira (OG) Out - Undisclosed. N. Shaw (CB) Out - Undisclosed. S. Murray (CB) Out - Undisclosed. C. Campbell Jr. (RB) Out - Undisclosed. D. Blue-Eli (DL) Out - Undisclosed. R. Langsdale (OG) Out - Undisclosed. D. Gilley (CB) Out - Undisclosed. F. Toure (WR) Out - Knee.

Ohio State Buckeyes:  A. Tounkara (DL) Questionable - Undisclosed. C. Tate (WR) Questionable - Undisclosed. M. Roy (DL) Questionable - Undisclosed. J. Padilla (OG) Questionable - Undisclosed. E. Mensah (DL) Questionable - Undisclosed. M. Maggs (QB) Questionable - Undisclosed. D. Jones (WR) Questionable - Undisclosed. L. George (DL) Questionable - Undisclosed. M. Hartford (S) Questionable - Undisclosed. J. Carter (DL) Questionable - Undisclosed. C. Donaldson (RB) Questionable - Undisclosed.

Notable Quotes


“Every game, we anticipated really wanting to run the football. But to say that I anticipated 41 carries; that would not be true.” - Greg Schiano after his team’s win against Maryland in their last game. 


“It was businesslike, workmanlike. We had an opportunity to play some of the younger guys, we got the run game going, defense played strong and the kickoff return was good to see." - Ryan Day after his team’s win against UCLA in their last game. 


Starting Lineups


Rutgers Scarlet Knights
WR Duff, KJ
WR Strong, Ian
WR Sheffield, DT
TE Fletcher Jr., Kenny
QB Kaliakmanis, Athan
RB Raymond, Antwan

Ohio State Buckeyes
WR Tate, Carnell
WR Smith, Jeremiah
WR Inniss, Brandon
TE Klare, Max
QB Sayin, Julian
RB Jackson, Bo

Statistical Leaders


Rutgers Scarlet Knights
Passing: Athan Kaliakmanis (2,705)
Rushing: Antwan Raymond (1,000)
Receiving: KJ Duff (923)
Touchdowns: Antwan Raymond (12)

Ohio State Buckeyes
Passing: Julian Sayin (2,675)
Rushing: Bo Jackson (725)
Receiving: Jeremiah Smith (902)
Touchdowns: Jeremiah Smith (11)

Coaches:
Rutgers Scarlet Knights: Greg Schiano (6th season)
Ohio State Buckeyes: Ryan Day (8th season)


Rod Pearson

About the Author:

Rod Pearson has been a rabid sports fan his entire life.  He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years.  In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective.  Join Rod every day as he breaks down the games to find the best betting value.

All photographic images used for editorial content have been licensed from the Associated Press.

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