Portland Trail Blazers vs San Antonio Spurs Prediction, Preview and Odds - 04/28/2026

Game Time: 9:30 pm ET, Tuesday, April 28, 2026

Venue:  Frost Bank Center, San Antonio, TX

Where to Watch:  ESPN

DraftKings:  Point Spread:  Trail Blazers +11.5, Spurs -11.5; Over/Under:  215.5 points

Bet365:  Point Spread:  Trail Blazers +11.5, Spurs -11.5; Over/Under:  215.5 points

BetMGM:  Point Spread:  Trail Blazers +12.5, Spurs -12.5; Over/Under:  215.5 points

Portland Trail Blazers:  42-40 (4th place, Northwest Division)

San Antonio Spurs:  62-20 (1st place, Southwest Division)

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Portland Trail Blazers:  5-5 last 10

San Antonio Spurs:  7-3 last 10

The Trail Blazers are entering the playoffs with a 42-40 record overall this season and they were 18-23 in their road games where they will be in this game. They are entering this game on a 2 game losing streak with losses coming against the San Antonio Spurs twice in a row. Deni Avdija led the team in points in that game with 26 while Jrue Holiday was next on the team with 20 points. Jrue Holiday led the team in assists in that game with 4 while Deni Avdija led the team in rebounds with 7. They were 40% from the field, 32.3% from 3-point range, and 82.6% from the free throw line with their shots in that game. Their offense is averaging 115.5 PPG and their defense is allowing their opponents to average 115.8 PPG against them. The Trail Blazers have an ATS record of 46-41 this season and their O/U record is 44-43.

The Spurs are entering the playoffs with a 62-20 record overall this season and they were 32-8 in their home games where they will be in this game. They are entering this game on a 2 game winning streak with wins coming against the Portland Trail Blazers twice in a row. De'Aaron Fox led the team in points in that game with 28 while Victor Wembanyama was next on the team with 27 points. Stephon Castle led the team in assists in that game with 8 while Victor Wembanyama led the team in rebounds with 12. They were 49.4% from the field, 42.4% from 3-point range, and 82.4% from the free throw line with their shots in that game. Their offense is averaging 119.8 PPG and their defense is allowing their opponents to average 111.5 PPG against them. The Spurs have an ATS record of 49-36-2 this season and their O/U record is 38-49.

The current betting odds have the Spurs listed as an 11.5 point favorite in this game according to Draftkings Sportsbook. The Spurs have looked great in their games this season with their 62-20 record overall which had them right near the top of the West with one of the best records in the entire NBA. They have looked great on their home court too with their 32-8 home record this season. Meanwhile, the Trail Blazers have looked good in their games this season with their 42-40 record overall which had them right in the middle of the West. They haven't been a great road team though with their 18-23 road record this year. This is game 5 of a 7-game series between the 2 seeded Spurs and the 7 seeded Trail Blazers in the West for the 1st round of the NBA playoffs. The Spurs are entering this game with a 3-1 series lead after winning game 4 by a score of 114-93. The Spurs started this series with a big win in game 1 and then dropped game 2 at home. They lost Wemby to an injury in that one and it looked like they were going to be in for some trouble going on the road the next 2 games, but they regrouped really well and now they are on the verge of kicking the Trail Blazers out of the playoffs. They really stepped in game 3 without Wemby and still won that game by double digits, then they got Wemby back for game 4 and erased an early double digit deficit to go on and win by double digits themselves in the end. Now the Spurs have won 2 games in a row by double digits and they have all of the momentum in this series going back home with a chance to eliminate their opponent. They have a ton of talent on their team and have been one of the best teams in the NBA all season too. The Trail Blazers had a really up and down season and got really hot at the end, but now they are 5-5 in their last 10 games and look like a team that is just completely outmatched. The Trail Blazers had a nice run, but they have been overachieving this season anyway and this is where their year comes to an end against a far superior opponent. The best way to place a bet here is on the Spurs to cover the spread in this game. 

Trail Blazers Spurs Prediction:  Our NBA Pick for Tuesday, April 28, 2026 (9:30 pm ET start time) is Spurs 116 Trail Blazers 96.

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Portland Trail Blazers: 12-6 ATS off a home loss. 25-16 ATS revenging a loss vs opponent. 24-15 ATS versus good 3 point shooting teams - making 36% of their attempts or more. 15-5 UNDER versus good rebounding teams - outrebounding opponents by 3+ per game. 8-4 UNDER versus poor pressure defensive teams - forcing 13 turnovers/game or less.

San Antonio Spurs: 7-12 ATS as a home favorite of 6.5 to 12 points. 22-29 ATS off a road win. 3-7 ATS at home against Northwest division opponents. 15-6 UNDER when playing against a marginal winning team (Win Pct. 51% to 60%). 10-5 UNDER as a home favorite of 6.5 to 12 points.

Portland Trail Blazers:  D. Lillard (PG) Out For Season - Achilles.

San Antonio Spurs:  D. Jones Garcia (SF) Out For Season - Ankle.

“You can be tough, you can be, you know, physical, but there’s a level of disrespect that I’m not gonna accept.” - Deni Avdija after their loss against the Spurs in the 4th game of this series on Sunday. 

“We need to find the answers before having our back against the wall. But that also shows the strength of our team in adversity. We stick together. We get closer to each other, we feed off of each other's energy.” - Victor Wembanyama after their win against the Trail Blazers in game 4 of this series on Sunday. 

PG Scoot Henderson

SG Jrue Holiday

SF Toumani Camara

PF Deni Avdija

C Donovan Clingan

PG De'Aaron Fox

SG Stephon Castle

SF Devin Vassell

PF Julian Champagnie

C Victor Wembanyama

PPG: Deni Avdija (24.2)

APG: Deni Avdija (6.7)

Reb/G: Donovan Clingan (11.6)

PPG: Victor Wembanyama (25)

APG: Stephon Castle (7.4)

Reb/G: Victor Wembanyama (11.5)

Coaches:

Portland Trail Blazers: Tiago Splitter (1st season)

San Antonio Spurs: Mitch Johnson (2nd season)