Pittsburgh Pirates vs New York Yankees Prediction, Preview and Odds - 07/21/2026

Game Time: 7:05 pm ET, Tuesday, July 21, 2026

Venue:  Yankee Stadium, Bronx, NY 

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Pirates +123, Yankees -149; Over/Under:  9 runs

Bet365:  Moneyline odds:  Pirates +125, Yankees -150; Over/Under:  9 runs

BetMGM:  Moneyline odds:  Pirates +125, Yankees -150; Over/Under:  9 runs

Pittsburgh Pirates:  52-48 (4th place, NL Central)

New York Yankees:  55-44 (2nd place, AL East)

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Pittsburgh Pirates:  7-3 last 10

New York Yankees:  6-4 last 10

The Pirates are entering this series off a win and won their 3-game series against the Cleveland Guardians 2-1 in their last series. They enter this game with a 52-48 record overall and have a road record of 25-24. This is the 2nd game of a 3-game series with the Yankees on Tuesday with the series opener still to be played on Monday. Their offense ranks 2nd in the MLB with a .769 OPS. Braxton Ashcraft is their starting pitcher on Monday while Bubba Chandler is making his start in this game on Tuesday. He is 3-8 with a 4.77 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 2 ER, 0 HR, and 3 BB with 6 SO on 5 hits through 4.2 IP against the Milwaukee Brewers.

The Yankees are entering this series off a win and lost their 3-game series against the Los Angeles Dodgers 2-1 in their last series. They enter this game with a 55-44 record overall and have a home record of 24-22. This is the 2nd game of a 3-game series with the Pirates on Tuesday with the 1st game of this series still to be played on Monday. Their offense ranks 6th in the MLB with a .738 OPS. Ryan Weathers is their starting pitcher on Monday while Will Warren is making his start in this game on Tuesday. He is 7-4 with a 4.03 ERA this season. His team lost 4 of their last 5 games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 1 homer, and 2 walks with 2 strikeouts on 4 hits through 5 innings pitched against the Washington Nationals.

The current betting odds have the Pirates listed as an underdog in this game according to Draftkings Sportsbook. The Pirates have looked good in their games this season with their 52-48 record overall, but that record has them right near the bottom of the NL Central in a competitive division. They have been a good road team too with their 25-24 road record this year. Meanwhile, the Yankees have looked really good in their games this season with their 55-44 record overall which has them right near the top of the AL East. They have looked good in their own ballpark too with their 24-22 home record this season. The Yankees are 6-4 in their last 10 games and they have looked good lately, but they came out of the All-Star break with a series loss to the Dodgers and they are dealing with some injuries that have hurt their offense lately. The Pirates have one of the best offenses in the league at the moment and they have been rolling lately, now 7-3 in their last 10 games. Chandler is on the mound for the Pirates in this one and he hasn't looked great this season. He is 3-8 with a 4.77 ERA, but lately he hasn't been giving up as many runs in his starts and the team has been having a ton of success with him too. He only gave up 2 earned runs in his last start which is starting to become a common theme for him lately and the team has won 2 games in a row now with him starting too. the Yankees are going with Warren in this one and he hasn't looked that great this season either. He is 7-4 with a 4.03 ERA and lately he hasn't been giving up many runs, but that hasn't been a common theme for him this year and the team has been having a lot of trouble with him too. He only gave up 1 earned run in his last start, but that has been a rare occurence for him and the team has lost 3 of their last 4 games with him starting. Neither team is going to have great pitching here with these starters, but Chandler has shown a lot of improvement lately and the Pirates also have the stronger offense right now. The best way to place a bet here is on the Pirates to win this game. 

Pirates Yankees Prediction:  Our MLB Pick for Tuesday, July 21, 2026 (7:05 pm ET start time) is Pirates 7 Yankees 5.

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Pittsburgh Pirates: 18-9 (+9.4 units) on the moneyline in an inter-league game. 43-30 (+10.2 units) on the moneyline against right-handed starters. 14-9 (+5.4 units) on the moneyline vs. an AL team with an on base percentage .330 or worse. 39-22 UNDER when the total is 9 to 9.5.

New York Yankees: 1-5 (-5.5 units) on the moneyline against NL Central opponents. 24-22 (-10.4 units) on the moneyline in home games. 23-19 (-8.5 units) on the moneyline as a home favorite of -110 or higher. 31-19 UNDER when the money line is -100 to -150.

Pittsburgh Pirates:  O. Cruz (CF) Sixty Day IL - Hand. K. Griffin (SS) Sixty Day IL - Finger. E. Rodriguez (C) Ten Day IL - Lower Body. E. Sisk (RP) Fifteen Day IL - Elbow. S. Horwitz (1B) Ten Day IL - Hamstring. C. Devenski (RP) Sixty Day IL - Illness.

New York Yankees:  A. Judge (RF) Sixty Day IL - Rib. C. Rodon (SP) Fifteen Day IL - Elbow. M. Fried (SP) Fifteen Day IL - Elbow. G. Stanton (DH) Ten Day IL - Leg. C. Schmidt (SP) Sixty Day IL - Elbow.

“Doubleheader yesterday, going 18 innings, to have Paul come out, go seven, and do what he does -- he was really good. Really efficient early on, and then found a way to navigate through a little bit of traffic. But felt like he was in command most of the time." - Don Kelly after his team’s win against the Guardians in their game on Sunday. 

“We’ve got to be more consistent offensively, first and foremost. That’s been the biggest thing that I think has ailed us through these few weeks. There were a couple of games where we didn’t play clean, but as a group, we’ve got to get going offensively and just be a little more complete.” - Aaron Boone after his team’s split against the LA Dodgers in their double-header on Sunday.

Jake Mangum (S) LF

Jared Triolo (R) 3B

Bryan Reynolds (S) DH

Esmerlyn Valdez (R) RF

Ryan O'Hearn (L) 1B

Nick Gonzales (R) 2B

Jacob Gonzalez (L) SS

Henry Davis (R) C

Billy Cook (R) CF

Trent Grisham (L) CF

Ben Rice (L) DH

Paul Goldschmidt (R) 1B

Cody Bellinger (L) LF

Jasson Domínguez (S) RF

Jazz Chisholm Jr. (L) 2B

Anthony Volpe (R) SS

Austin Wells (L) C

José Caballero (R) 3B

Batting Average:  Rafael Flores (.333)

Hits:  Nick Gonzales (109)

Home Runs:  Brandon Lowe (21)

RBI:  Brandon Lowe (65)

Stolen Bases:  Oneil Cruz (21)

Wins:  Braxton Ashcraft (9)

Saves:  Gregory Soto (12)

ERA:  Khristian Curtis (0.00)

Batting Average:  Ben Rice (.281)

Hits:  Ben Rice (98)

Home Runs:  Ben Rice (29)

RBI:  Ben Rice (68)

Stolen Bases:  Jazz Chisholm (26)

Wins:  Cam Schlittler (9)

Saves:  David Bednar (18)

ERA:  Yovanny Cruz (0.00)

Managers:

Pittsburgh Pirates: Don Kelly (2nd season)

New York Yankees: Aaron Boone (9th season)