Pittsburgh Penguins vs Philadelphia Flyers Prediction, Preview and Odds - 04/22/2026

Game Time: 7:00 pm ET, Wednesday, April 22, 2026

Venue:  Xfinity Mobile Arena, Philadelphia, PA 

Where to Watch:  TNT, HBO Max, truTV

DraftKings:  Moneyline:  Penguins -105, Flyers -115; Over/Under:  5.5 goals

Bet365:  Moneyline:  Penguins -105, Flyers -115; Over/Under:  5.5 goals

BetMGM:  Moneyline:  Penguins +100, Flyers -120; Over/Under:  5.5 goals

Pittsburgh Penguins:  41-25-16 (2nd place, Metropolitan Division)

Philadelphia Flyers:  43-27-12 (3rd place, Metropolitan Division)

Do not miss out on our expert handicapper analysis! Amedeus Mastrangelo is on a HOT STREAK in the NHL on a 7-2 NHL RUN for +$5,820 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Pittsburgh Penguins:  4-6-0 last 10

Philadelphia Flyers:  8-2-0 last 10

The Penguins are entering the playoffs with 98 points, a 41-25-16 record overall, and they were 21-12-8 in their road games this season where they will be in this game. They are entering this game off a loss against the Philadelphia Flyers in their last game, losing that one at home 3-0. No one on the team scored a goal for them or recorded an assist in that one as the team was shut out. Sidney Crosby led the team in shots on net in that game with 4. Stuart Skinner was the starting goalie in that game and he allowed 2 goals on 22 shots with 20 saves and a .909 sv percentage. Their offense has scored 293 goals this season averaging 3.6 goals per game and their defense has allowed their opponents to score 268 goals against them allowing 3.3 goals per game.

The Flyers are entering the playoffs with 98 points, a 43-27-12 record overall, and they were 20-13-8 in their home games this season where they will be in this game. They are entering this game off a win against the Pittsburgh Penguins in their last game, winning that one on the road 3-0. Garnet Hathaway, Luke Glendening, and Porter Martone each scored 1 goal for them in that one. Garnet Hathaway, Christian Dvorak, Owen Tippett, Sean Couturier, and Travis Konecny each led the team in assists with 1 while Porter Martone led the team in shots on net in that game with 6. Dan Vladar was the starting goalie in that game and he recorded the shutout as he allowed 0 goals on 27 shots with 27 saves and a 1.000 save percentage. Their offense has scored 250 goals this season averaging 3 goals per game and their defense has allowed their opponents to score 243 goals against them allowing 3 goals per game.

The current betting odds have the Flyers listed as a slight favorite in this game according to Draftkings Sportsbook. The Flyers have looked good in their games this season with their 43-27-12 record overall which had them in the top half of their division in the East. They have looked good on home ice too with their 20-13-8 home record this season. Meanwhile, the Penguins have looked good in their games this season with their 41-25-16 record overall which had them right near the top of their division in the East. They have been a good road team too with their 21-12-8 road record this year. This is game 3 of a 7-game series between the 2nd seeded Penguins and the 3rd seeded Flyers in the Metro for the 1st round of the NHL playoffs. The Flyers are entering this game with a 2-0 series lead after winning game 2 by a score of 3-0. The Flyers have been rolling in their games lately and they are one of the hottest teams in the NHL over the last few weeks, fighting to get that last spot in the Metro. They are 8-2-0 in their last 10 games now and have taken both road games in this series, but this is still a big rivalry and the Penguins aren't going to go down without a fight. The Penguins have been the better team all season and even though they are off to a slow start in this series, they are going to leave everything they have on the ice in this one. The Penguins haven't been a bad road team this season so they are going to have no issues going on the road with their backs against the wall here. This is going to be a game of desperation for the Penguins, so look for them to bring their best effort here to get one back in the series or this series is pretty much over. The best way to place a bet here is on the Penguins to win this game. 

Penguins Flyers Prediction:  Our NHL Pick for Wednesday, April 22, 2026 (7:00 pm ET start time) is Penguins 3 Flyers 2.

Don't miss our champion handicappers free picks and expert hockey picks today. And if you enjoyed this Pittsburgh Penguins Philadelphia Flyers prediction, be sure to drop by every day for our weekly NHL predictions and previews.

Pittsburgh Penguins: 24-18 (+8.9 units) on the moneyline revenging a loss versus opponent as a favorite. 20-15 (+5.4 units) on the moneyline after 3 or more consecutive losses. 28-18 OVER against explosive offensive teams - scoring 3+ goals/game.

Philadelphia Flyers: 16-22 (-7.1 units) on the moneyline in a home game where the total is 5.5. 54-56 (-8.8 units) on the moneyline when playing against a team with a losing record. 8-16 (-7.2 units) on the moneyline after a 3 game winning streak. 17-10 OVER after 3 or more consecutive unders.

Pittsburgh Penguins:  C. Jones (D) Out For Season - Shoulder. F. Hallander (C) Out - Leg.

Philadelphia Flyers:  E. Andrae (D) Day To Day - Upper-body. N. Grebenkin (RW) Out - Upper Body. R. Abols (C) Out - Ankle.

“(We) should be frustrated, we just lost two games at home. But with frustration it’s how are you going to respond. Nobody is happy. Nobody should be.” - Dan Muse after his team’s loss against the Flyers in the 2nd game of this series on Monday. 

“He’s been like that all year for us. Guys enjoy playing for him.” - Rick Tocchet on Dan Vladar after his team’s win against the Penguins in game 2 of this series on Monday. 

LW Yegor Chinakhov

C Sidney Crosby

RW Bryan Rust

LD Parker Wotherspoon

RD Erik Karlsson

G Stuart Skinner

LW Tyson Foerster

C Trevor Zegras

RW Owen Tippett

LD Travis Sanheim

RD Rasmus Ristolainen

G Dan Vladar

Points: Sidney Crosby (74)

Goals: Anthony Mantha (33)

Assists: Erik Karlsson (51)

GAA: Stuart Skinner (2.99)

Points: Travis Konecny (68)

Goals: Owen Tippett (28)

Assists: Travis Konecny (41)

GAA: Dan Vladar (2.42)

Coaches:

Pittsburgh Penguins: Dan Muse (1st season)

Philadelphia Flyers: Rick Tocchet (1st season)