Pittsburgh Panthers vs Louisville Cardinals Prediction, Picks and Game Preview - 10/22/2022

by Rod Pearson

Wednesday, Oct 19, 2022
Game Time: 8:00 pm ET, Saturday, October 22, 2022
Venue:  Cardinal Stadium, Louisville, KY 
Where to Watch:  ACC Network

 

Opening Odds at USA Sportsbooks

DraftKings:  Point Spread:  Pittsburgh +2.5, Louisville -2.5; Over/Under:  55 points
Bet365:  Point Spread:  Pittsburgh +2.5, Louisville -2.5; Over/Under:  55 points
BetMGM:  Point Spread:  Pittsburgh +2.5, Louisville -2.5; Over/Under:  55.5 points
 

Season Record

Pittsburgh Panthers:  4-2 (1-1) (3rd place, ACC Coastal)
Louisville Cardinals:  3-3 (1-3) (6th place, ACC Atlantic)
 
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Recent Form
Pittsburgh Panthers:  won their last game at home against the Virginia Tech Hokies 45-29.
Louisville Cardinals:  won their last game on the road against the Virginia Cavaliers 34-17.

 

Pittsburgh Panthers vs Louisville Cardinals Preview and Analysis

 
Pittsburgh is entering this game with a 4-2 record overall to start their college football season and they will be playing their 2nd road game of the season here as they are 1-0 in their road games this year. This will also be their 3rd conference game of the college football season this year as they are 1-1. They won against the VA Tech Hokies in their last game at home 45-29. Kedon Slovis started that game at QB and he completed 15/28 passes for 170 yards and 1 interception. Israel Abanikanda led the team in rushing with 320 yards and 6 TDs on 36 rushing attempts. Jaden Bradley led the team in receiving with 66 yards on 5 receptions. Shayne Simon led the defense in that game with 4 solo tackles and 5 assisted tackles. SirVocea Dennis, Solomon DeShields, and Deslin Alexandre each led the defense in sacks with 1 while Erick Hallett came away with the only interception for them in that one.
 
 
 
Louisville is entering this game with a 3-3 record overall to start their college football season and they will be playing their 3rd home game of the season as they are 1-1 in their home games this year. This will also be the 5th conference matchup on their conference schedule this season as they are 1-3. They won against the Virginia Cavaliers in their last game on the road 34-17. Brock Domann started that game at QB and he completed 17/30 passes for 275 yards, 1 touchdown, and 2 interceptions. Trevion Cooley led the team in rushing with 77 yards and 1 TD on 18 carries. Tyler Hudson led the team in receiving with 101 yards on 7 receptions. Josh Minkins and Jarvis Brownlee each led the defense in that game with 5 solo tackles and 1 assisted tackle. Mason Reiger, Monty Montgomery, Ashton Gillotte, Dezmond Tell, Yasir Abdullah, and Jared Dawson each led the defense in sacks with 1 while Jarvis Brownlee and M.J. Griffin each came away with 1 interception for them in that one.

 

Pittsburgh vs Louisville Prediction

The current betting odds have Pittsburgh listed as a 2.5 point underdog in this game according to Draftkings Sportsbook. Pittsburgh took a bad loss to Georgia State a few weeks ago but they bounced back in their last game with a big win over Virginia Tech. They dropped 45 points on VA Tech as their offense has been very good all year. Louisville also pulled off a big conference win in their last game playing with their backup QB, but they won against Virginia who has been terrible this year and they are about to get a much tougher test here. This is going to be the 1st real road test for Pittsburgh too with their only other road game coming in a win against Western Michigan. Louisville hasn't been great though and Malik Cunningham, who is banged up right now, has really been their only source of offense this season. Louisville can score a lot of points in their games but their defense has been really bad and they are going to allow Pittsburgh to move the ball and score a lot of points themselves here. Pittsburgh also has the better defense so they will be able to get some stops on this banged up Louisville offense that hasn't been at it's best lately. The best way to place a bet here is on Pittsburgh to cover the spread in this game.
 
Pittsburgh Louisville Prediction:  Our NCAAF Pick for Saturday, October 22, 2022 (8:00 pm ET start time) is Pittsburgh 31 Louisville 24.
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NCAAF Betting Trends

 
Pittsburgh Panthers: 14-20 ATS as a road underdog of 7 points or less. 21-10 OVER in all games. 10-3 OVER off 2 or more consecutive overs.
Louisville Cardinals: 6-0 ATS off an upset win by 14 points or more as a road underdog. 24-15 ATS in a home game where the total is between 49.5 and 56. 6-0 OVER after a win by 17 or more points.
 

Key Injuries

 
Pittsburgh Panthers:  N. Patti (QB) Ques Sat - Leg. K. Mumpfield (WR) Ques Sat - Undisclosed. R. Hammond Jr. (RB) Out indefinitely - Leg. N. Temple (DL) out for season - Leg.
Louisville Cardinals:  E. Conley (QB) Out indefinitely - Undisclosed. D. Wiggins (WR) out of season - Toe. J. Lole (DL) out for season - Elbow.
 

Notable Quotes

 
“I’d say it’s maybe above average. I wouldn’t say it’s a winning effort every time. I’d say it’s above average right now. And I think it can be better. And, again, he thinks it can be better as well.” - Pat Narduzzi on the play of Kedon Slovis in their games this season.
 
 
"I was in my own way in the first quarter. As much as you want to prepare for your first start, you need to get out of your own way. Once I did that, this team was amazing." - Brock Domann on getting the start in their win against Virginia in their last game.
 
 

Starting Lineups

 
Pittsburgh Panthers
WR Wayne, Jared
WR Means, Bub
WR Mumpfield, Konata 
TE Bartholomew, Gavin
QB Slovis, Kedon
RB Abanikanda, Israel 
 
Louisville Cardinals
WR Hudson, Tyler
WR Huggins-Bruce, Ahmari 
WR Smith, Braden 
TE Ford, Marshon 
QB Cunningham, Malik
RB Evans, Tiyon 
FB Martin, Duane 
 

Statistical Leaders

 
Pittsburgh Panthers
Passing: K. Slovis (1167)
Rushing: I. Abanikanda (830)
Receiving: J. Wayne (390)
Touchdowns: I. Abanikanda (13)
 
Louisville Cardinals
Passing: M. Cunningham (962)
Rushing: M. Cunningham (457)
Receiving: T. Hudson (413)
Touchdowns: M. Cunningham (9)
 
Coaches:
Pittsburgh Panthers: Pat Narduzzi (8th season)
Louisville Cardinals: Scott Satterfield (4th season)


Rod Pearson

About the Author:

Rod Pearson has been a rabid sports fan his entire life.  He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years.  In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective.  Join Rod every day as he breaks down the games to find the best betting value.

All photographic images used for editorial content have been licensed from the Associated Press.

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