Pittsburgh Panthers vs Duke Blue Devils Prediction, Picks and Game Preview - 11/06/2021

by Amedeus Mastrangelo

Game Time: 12:00 pm ET, Saturday, November 6, 2021
Venue:  Wallace Wade Stadium, Durham, NC
Where to Watch:  ACC Network


Opening Odds at USA Sportsbooks

DraftKings:  Point Spread:  Pittsburgh -20.5, Duke +20.5; Over/Under:  64 points
Bet365:  Point Spread:  Pittsburgh -21, Duke +21; Over/Under:  64 points
BetMGM:  Point Spread:  Pittsburgh -20.5, Duke +20.5; Over/Under:  64.5 points

Season Record

Pittsburgh Panthers:  6-2 (1st place, ACC Coastal)
Duke Blue Devils:  3-5 (7th place, ACC Coastal)
Do not miss out on our expert handicapper analysis! Ben Burns is on a RUN of 29-12 L41 (10*) PLAYS! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.


Pittsburgh Panthers vs Duke Blue Devils Preview and Analysis

Recent Form
Pittsburgh Panthers:  lost at home on Oct. 30 against the Miami Hurricanes 38-34.
Duke Blue Devils:  lost on the road on Oct. 30 against the Wake Forest Demon Deacons 45-7.

Pittsburgh Panthers Analysis

The Pitt Panthers are coming into this college football game with a 6-2 record overall and they are 3-0 in their road games this season where they will be in this game. This will be their 5th conference matchup of the year and they are still leading the way with a 3-1 record in their conference games this season. They just had a 4 game winning streak snapped in their last game with a loss to the Miami Hurricanes football team. That game was close at the end after Pittsburgh made a second half comeback but they were trailing for the entire game and never really had the lead in that one as they went on to lose. Kenny Pickett played well at times in that game but he also struggled a lot as he completed 39/55 passes for 519 yards, 3 touchdowns and 2 interceptions. Vincent Davis led the team in rushing with 45 yards on 6 carries while Israel Abanikanda ran in the only TD for them on the ground in that one. they did not really have much of a running game in that one. Jordan Addison had a nice day as he led the receivers with 145 yards on 8 receptions while Taysir Mack was right behind him with 92 yards on 5 receptions. Jared Wayne also had 78 yards and 1 TD on 6 receptions while Abanikanda and Jaylon Barden both caught the other touchdown passes in that game with 1 each. Erick Hallett led the defense in that game with 6 solo tackles and 3 assisted ones. John Morgan, Calijah Kancey, and Habakkuk Baldonado all led the defense in sacks with 1 each while John Petrishen came away with the only interception for them in that one. They have scored 351 points in their 8 games this season averaging 43.9 PPG and they have allowed their opponents to score 175 points against them allowing 21.9 PPG. Their offense is averaging 529.1 YPG while the Pitt defense is allowing 341.3 YPG.

Duke Blue Devils Analysis

Duke is coming into this game with a 3-5 record overall and they are 3-1 in their home games this season where they will be in this game. This will be the 5th conference matchup on their schedule this year and they are out of the title contention with a 0-4 record in their conference games this season. Duke started their regular season with a positive 3-1 but have lost their last 4 games straight since then, all of them on the road and against a conference opponent. They are coming off of a loss against Wake Forest in a game that they were dominated in from start to finish only scoring the 1 TD. Gunnar Holmberg did not have a good game as he completed 10/18 passes for 110 yards. Mataeo Durant had a nice day on the ground as he led the team in rushing with 103 yards on 20 carries while Riley Leonard scored the only touchdown in that game for them on the ground. Jalon Calhoun led the receivers with 50 yards on 3 receptions in what was a very quiet day for the receiving corps. Leonard Johnson led the defense in that game with 9 solo tackles. RJ Oben led the defense in sacks in that game with 1 while no one was able to come away with an interception for them. They have scored 196 points in their 8 games this season averaging 24.5 PPG and they have allowed their opponents to score 266 points against them allowing 33.3 PPG. Their offense is averaging 454.5 YPG while their defense is allowing 473.8 YPG.


Pittsburgh vs Duke Prediction

The Pittsburgh Panthers football team is coming into this game as a 20.5 point favorite with the current betting odds according to Draftkings Sportsbook. Pittsburgh is going to be angry from their loss in their last game and they will be looking to take it out on Duke here. Duke has only scored 7 points in 2 games now and have allowed their opponents to score at least 45 on them in their last 2 games. Pittsburgh is going to hold nothing back here but Duke is not even good enough on defense to stop this Wake Forest offense that is scoring so many points. The best bet to place in this game is on Pittsburgh to cover the spread here.
Pittsburgh Duke Prediction:  Our NCAAF Pick for Saturday, November 6, 2021 (12:00 pm ET start local time) is Pittsburgh 56 Duke 7.
Don't miss our champion handicappers free picks and expert football picks today.  And if you enjoyed this Pittsburgh Panthers Duke Blue Devils prediction, be sure to drop by every day for our weekly NCAA football predictions and previews.

NCAAF Betting Trends

Pittsburgh Panthers: 16-24 ATS as a favorite of 10.5 to 21 points. 167-174 ATS in all games. 80-90 ATS as a favorite. 101-103 ATS in games played on a grass field.
Duke Blue Devils: 172-162 ATS in all games. 131-117 ATS as an underdog. 53-51 ATS as a home underdog. 50-48 ATS off 1 or more consecutive unders.

Key Injuries

Pittsburgh Panthers:  A. Davis Jr. (RB) day-to-day - Undisclosed injury. G. Thomson (WR) day-to-day - Undisclosed injury. J. Barden (WR) day-to-day - Undisclosed injury.
Duke Blue Devils:  M. Smith (TE) out for season - Knee injury.

Notable Quotes

"Never had a lead in the game, and I thought we were going to take it in the fourth quarter and (we) fell short at the end. Tough one to swallow, but we will bounce back. All our goals are still in front of us. Still disappointing." - Pat Narduzzi on their loss to Miami in their last game.
"We could pick a million things. It's pretty obviously over and over and over where there are a lot of struggles. But the answers all lie within us, and we've got to find those answers." - David Cutcliffe after another blowout loss in their last game.

Starting Lineups (Stats)

Pittsburgh Panthers
WR Taysir Mack
WR Jacques-Louis, Shocky 
WR Addison, Jordan 
TE Krull, Lucas 
QB Pickett, Kenny 
RB Abanikanda, Israel 
Duke Blue Devils
WR Bobo, Jake 
WR Pancol, Eli 
WR Calhoun, Jalon 
TE Marwede, Jake 
QB Holmberg, Gunnar 
RB Durant, Mataeo 

Statistical Leaders

Pittsburgh Panthers
Passing: K. Pickett (2755)
Rushing: I. Abanikanda (431)
Receiving: J. Addison (815)
Touchdowns: J. Addison (10)
Duke Blue Devils
Passing: G. Holmberg (1860)
Rushing: M. Durant (973)
Receiving: J. Bobo (592)
Touchdowns: M. Durant (9)
Pittsburgh Panthers: Pat Narduzzi (7th season)
Duke Blue Devils: David Cutcliffe (14th season)

Amedeus Mastrangelo

About the Author:

Amedeus Mastrangelo has been heavily wagering on all sports for years and plays just about everything, including sides, totals, favorites, underdogs, against the spread, alternative spreads, first half, second half, player props, and futures. The bottom line is, if Mastrangelo can see an edge in any way shape or form, then he's going to take advantage.

All photographic images used for editorial content have been licensed from the Associated Press.

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