Philadelphia Phillies vs Houston Astros Prediction, Preview and Odds - 06/26/2025

Game Time: 2:10 pm ET, Thursday, June 26, 2025

Venue:  Daikin Park, Houston, TX

Where to Watch:  NBCS-P, SCHN

DraftKings:  Moneyline odds:  Phillies +118, Astros -144; Over/Under:  7 runs

Bet365:  Moneyline odds:  Phillies +120, Astros -140; Over/Under:  7 runs

BetMGM:  Moneyline odds:  Phillies +120, Astros -145; Over/Under:  7 runs

Philadelphia Phillies:  47-32 (1st place, NL East)

Houston Astros:  46-33 (1st place, AL West)

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Philadelphia Phillies:  7-3 last 10

Houston Astros:  7-3 last 10

The Phillies are entering this series off a win and won their 3-game series against the New York Mets 2-1 in their last series. They enter this game with a 47-32 record overall and have a road record of 21-18. This is the series finale of a 3-game series with the Astros on Thursday with the 2nd game still to be played on Wednesday. The Phillies lost the series opener on Tuesday. Their offense ranks 8th in the MLB with a .735 OPS. Zack Wheeler is their starting pitcher on Wednesday while Cristopher Sánchez is making his start in this game on Thursday. He is 6-2 with a 2.87 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 1 ER, 0 HR, and 0 BB with 4 SO on 5 hits through 8 IP against the Miami Marlins.

The Astros are entering this series off a win and won their 3-game series against the Los Angeles Angels 2-1 in their last series. They enter this game with a 46-33 record overall and have a home record of 28-13. This is the 3rd game of a 3-game series with the Phillies on Thursday with the 2nd game of this series still to be played on Wednesday. The Astros won the 1st game of this series on Tuesday. Their offense ranks 15th in the MLB with a .723 OPS. Rookie pitcher Colton Gordon is their starting pitcher on Wednesday while Hunter Brown is making his start in this game on Thursday. He is 8-3 with a 1.88 ERA this season. His team won their last 5 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 1 homer, and 2 walks with 4 strikeouts on 2 hits through 5 innings pitched against the Los Angeles Angels.

The current betting odds have the Astros listed as a favorite in this game according to Draftkings Sportsbook. The Astros have looked good in their games this season with their 46-33 record overall which has them right at the top of the AL West. They have also looked great in their own ballpark this year with their 28-13 home record. Meanwhile, the Phillies have looked really good in their games this season with their 47-32 record overall which has them right at the top of the NL East with one of the best records in the entire MLB. They have also been a good road team with their 21-18 road record. Both of these teams have been red hot lately as both are 7-3 in their last 10 games and both teams are going to have studs on the mound here too. This is a similar matchup to the 1st game of this series which had 2 studs on the mound, and that ended with a 1-0 win for the Astros so they should have enough to edge out the Phillies at home in a similar situation here. Wheeler is on the mound for the Phillies in this one and he has looked great this season. He is 6-2 with a 2.87 ERA and hasn't been giving up many runs lately. He only gave up 1 earned run in his last start and the team has won 2 games in a row with him starting now. The Astros are going with Brown in this one and he has pretty much been their ace this season. He is 8-3 with a 1.88 ERA and hasn't been giving up many runs at all. He only gave up 1 earned run in his last start and the team has had a ton of success with him starting, winning 5 games in a row now with him on the mound. Both of these teams have been great offensively, but the Astros should have enough to get the edge in this one like they did on Tuesday night. The best way to place a bet here is on the Astros to win this game. 

Phillies Astros Prediction:  Our MLB Pick for Thursday, June 26, 2025 (2:10 pm ET start time) is Astros 3 Phillies 2.

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Philadelphia Phillies: 241-178 (+9 units) on the moneyline in all games. 65-43 (+12.6 units) on the moneyline in an inter-league game. 165-116 (+13.6 units) on the moneyline against right-handed starters. 11-6 UNDER vs. a starting pitcher whose winning percentage is better than 70%.

Houston Astros: 230-183 (-6.9 units) on the moneyline in all games. 158-126 (-31.8 units) on the moneyline as a favorite of -110 or higher. 114-96 (-28.3 units) on the moneyline in home games. 20-12 UNDER against NL East opponents.

Philadelphia Phillies:  A. Nola (SP) Sixty Day IL - Ankle. B. Harper (1B) Ten Day IL - Wrist.

Houston Astros:  S. Dubin (RP) Fifteen Day IL - Forearm. B. Rodgers (2B) Ten Day IL - Oblique. L. McCullers Jr. (SP) Fifteen Day IL - Foot. J. Melton (CF) Ten Day IL - Ankle. S. Arrighetti (SP) Sixty Day IL - Thumb. Z. Dezenzo (RF) Ten Day IL - Hand. R. Blanco (SP) Sixty Day IL - Elbow. C. McCormick (LF) Ten Day IL - Oblique. H. Wesneski (RP) Sixty Day IL - Elbow. Y. Alvarez (LF) Ten Day IL - Hand. L. Garcia (SP) Sixty Day IL - Elbow. C. Javier (SP) Sixty Day IL - Elbow. P. Leon (RF) Sixty Day IL - Knee. J. France (SP) Sixty Day IL - Shoulder. 

"He's been huge. You can pretty much book six or seven innings every time. He's just been incredible, he really has." - Rob Thomson on Ranger Suarez after his team’s loss against the Astros in their game on Tuesday.

“Big swing. I feel like it’s the next-man-up mentality. It’s like everyone finding a way to help win games. Good teams do that. We need that. It’s contagious. Those guys in there, they want to be in the game. They’ll look at me like, ‘When am I going to get my spot so I can do something to help contribute?’ I love that about this team.” - Joe Espada on Cooper Hummel after his team’s win against the Phillies in their game on Tuesday.

Trea Turner (R) SS

Kyle Schwarber (L) DH

Alec Bohm (R) 3B

Nick Castellanos (R) RF

J.T. Realmuto (R) C

Otto Kemp (R) LF

Edmundo Sosa (R) 2B

Buddy Kennedy (R) 1B

Johan Rojas (R) CF

Jeremy Peña (R) SS

Isaac Paredes (R) 3B

Jose Altuve (R) DH

Jake Meyers (R) CF

Cam Smith (R) RF

Christian Walker (R) 1B

Yainer Diaz (R) C

Cooper Hummel (S) LF

Mauricio Dubón (R) 2B

Batting Average:  Trea Turner (.300)

Hits:  Trea Turner (95)

Home Runs:  Kyle Schwarber (24)

RBI:  Kyle Schwarber (55)

Stolen Bases:  Trea Turner (19)

Wins:  Zack Wheeler (7)

Saves:  Jordan Romano (8)

ERA:  Ranger Suárez (2.08)

Batting Average:  Jeremy Peña (.326)

Hits:  Jeremy Peña (100)

Home Runs:  Isaac Paredes (16)

RBI:  Isaac Paredes (45)

Stolen Bases:  Jeremy Peña (15)

Wins:  Hunter Brown (8)

Saves:  Josh Hader (20)

ERA:  Shawn Dubin (1.33)

Managers:

Philadelphia Phillies: Rob Thomson (4th season)

Houston Astros: Joe Espada (2nd season)