Philadelphia Phillies vs Houston Astros Prediction, Preview and Odds - 06/25/2025

by Rod Pearson

Tuesday, Jun 24, 2025
Game Time: 8:10 pm ET, Wednesday, June 25, 2025
Venue:  Daikin Park, Houston, TX
Where to Watch:  NBCS-P, SCHN


Opening Odds at USA Sportsbooks

DraftKings:  Moneyline odds:  Phillies -164, Astros +134; Over/Under:  7.5 runs
Bet365:  Moneyline odds:  Phillies -165, Astros +135; Over/Under:  7.5 runs
BetMGM:  Moneyline odds:  Phillies -165, Astros +135; Over/Under:  7.5 runs

Season Record

Philadelphia Phillies:  47-31 (1st place, NL East)
Houston Astros:  45-33 (1st place, AL West)

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Recent Form
Philadelphia Phillies:  8-2 last 10
Houston Astros:  7-3 last 10



Philadelphia Phillies vs Houston Astros Preview and Analysis


The Phillies are entering this series off a win and won their 3-game series against the New York Mets 2-1 in their last series. They enter this game with a 47-31 record overall and have a road record of 21-17. This is the 2nd game of a 3-game series with the Astros on Wednesday with the series opener still to be played on Tuesday. Their offense ranks 8th in the MLB with a .739 OPS. Ranger Suárez is their starting pitcher on Tuesday while Zack Wheeler is making his start in this game on Wednesday. He is 7-2 with a 2.61 ERA this season. His team won their last 3 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 0 ER, 0 HR, and 3 BB with 8 SO on 4 hits through 5 IP against the New York Mets.

The Astros are entering this series off a win and won their 3-game series against the Los Angeles Angels 2-1 in their last series. They enter this game with a 45-33 record overall and have a home record of 27-13. This is the 2nd game of a 3-game series with the Phillies on Wednesday with the 1st game of this series still to be played on Tuesday. Their offense ranks 12th in the MLB with a .725 OPS. Framber Valdez is their starting pitcher on Tuesday while rookie pitcher Colton Gordon is making his start in this game on Wednesday. He is 2-1 with a 4.54 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 2 earned runs, 2 homers, and 1 walk with 4 strikeouts on 7 hits through 5 innings pitched against the Athletics.


Phillies vs Astros Prediction

The current betting odds have the Phillies listed as a favorite in this game according to Draftkings Sportsbook. The Astros have looked good in their games this season with their 45-33 record overall which has them right at the top of the AL West. They have also looked great in their own ballpark this year with their 27-13 home record. Meanwhile, the Phillies have looked really good in their games this season with their 47-31 record overall which has them right at the top of the NL East with one of the best records in the entire MLB. They have also been a good road team with their 21-17 road record. Both of these teams have been rolling into this series as the Phillies are 8-2 in their last 10 games while the Astros are 7-3 in their last 10. The Phillies do have the better pitching matchup though and they can take advantage of that. Wheeler is on the mound for the Phillies in this one and he has looked great this year. He is 7-2 with a 2.61 ERA and hasn't been giving up many runs lately. He is coming off another great start in which he gave up no runs, something that has been a common theme for him all year, and the team has won 3 games in a row with him starting too. The Astros are going with Gordon in this one and he hasn't looked great this year. He is 2-1 with a 4.54 ERA and the team has won 2 of their last 3 games with him starting, but he is also in his rookie season and doesn't have a ton of experience pitching in the MLB. He only gave up 2 earned runs in his last start, but that hasn't really been a common theme for him and he will get himself into trouble with this hot Phillies offense that is one of the best in the MLB and has been rolling lately. The best way to place a bet here is on the Phillies to win this game. 

Phillies Astros Prediction:  Our MLB Pick for Wednesday, June 25, 2025 (8:10 pm ET start time) is Phillies 6 Astros 3.
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MLB Betting Trends


Philadelphia Phillies: 241-177 (+10 units) on the moneyline in all games. 65-42 (+13.6 units) on the moneyline in an inter-league game. 194-114 (+18.6 units) on the moneyline as a favorite of -110 or higher. 16-9 UNDER on the road vs. a team with a good bullpen whose ERA is 3.45 or better.

Houston Astros: 229-183 (-7.9 units) on the moneyline in all games. 7-14 (-10.1 units) on the moneyline after 6 consecutive games versus division rivals. 113-96 (-29.3 units) on the moneyline in home games. 13-7 UNDER as a home underdog of +100 or higher.

Key Injuries


Philadelphia Phillies:  A. Nola (SP) Sixty Day IL - Ankle. B. Harper (1B) Ten Day IL - Wrist.

Houston Astros:  B. Rodgers (2B) Ten Day IL - Oblique. L. McCullers Jr. (SP) Fifteen Day IL - Foot. J. Melton (CF) Ten Day IL - Ankle. S. Arrighetti (SP) Sixty Day IL - Thumb. Z. Dezenzo (RF) Ten Day IL - Hand. R. Blanco (SP) Sixty Day IL - Elbow. C. McCormick (LF) Ten Day IL - Oblique. H. Wesneski (RP) Sixty Day IL - Elbow. Y. Alvarez (LF) Ten Day IL - Hand. L. Garcia (SP) Sixty Day IL - Elbow. C. Javier (SP) Sixty Day IL - Elbow. P. Leon (RF) Ten Day IL - Knee. J. France (SP) Sixty Day IL - Shoulder. 


Notable Quotes


“I do. I do. Because I think he's comfortable with it. You can never tell until you get him into some games, but so far, he looks very comfortable. The drill work has been good, the routes have been good, the reaction time has been good. We'll see what we've got.” - Rob Thomson after his team’s win against the Mets in their game on Sunday.


“We’re never out of a game. Long 13-game stretch, and these guys, they fight till the end. So proud of this group.” - Joe Espada after his team’s win against the LA Angels in their game on Sunday.


Starting Lineups


Philadelphia Phillies
Trea Turner (R) SS
Kyle Schwarber (L) DH
Alec Bohm (R) 3B
Nick Castellanos (R) RF
J.T. Realmuto (R) C
Otto Kemp (R) LF
Edmundo Sosa (R) 2B
Buddy Kennedy (R) 1B
Johan Rojas (R) CF

Houston Astros
Jeremy Peña (R) DH
Jake Meyers (R) CF
Jose Altuve (R) 2B
Cam Smith (R) RF
Christian Walker (R) 1B
Victor Caratini (S) C
Cooper Hummel (S) LF
Mauricio Dubón (R) SS
Luis Guillorme (L) 3B

Statistical Leaders


Philadelphia Phillies
Batting Average:  Trea Turner (.300)
Hits:  Trea Turner (94)
Home Runs:  Kyle Schwarber (24)
RBI:  Kyle Schwarber (55)
Stolen Bases:  Trea Turner (19)
Wins:  Zack Wheeler (7)
Saves:  Jordan Romano (8)
ERA:  Ranger Suárez (2.20)

Houston Astros
Batting Average:  Jeremy Peña (.326)
Hits:  Jeremy Peña (99)
Home Runs:  Isaac Paredes (16)
RBI:  Isaac Paredes (45)
Stolen Bases:  Jeremy Peña (15)
Wins:  Hunter Brown (8)
Saves:  Josh Hader (19)
ERA:  Shawn Dubin (1.33)

Managers:
Philadelphia Phillies: Rob Thomson (4th season)
Houston Astros: Joe Espada (2nd season)


Rod Pearson

About the Author:

Rod Pearson has been a rabid sports fan his entire life.  He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years.  In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective.  Join Rod every day as he breaks down the games to find the best betting value.

All photographic images used for editorial content have been licensed from the Associated Press.

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