Philadelphia 76ers vs New York Knicks Prediction, Preview and Odds - 05/06/2026

Game Time: 7:00 pm ET, Wednesday, May 6, 2026

Venue:  Madison Square Garden, New York, NY

Where to Watch:  ESPN

DraftKings:  Point Spread:  76ers +6.5, Knicks -6.5; Over/Under:  214.5 points

Bet365:  Point Spread:  76ers +6.5, Knicks -6.5; Over/Under:  214.5 points

BetMGM:  Point Spread:  76ers +6.5, Knicks -6.5; Over/Under:  214.5 points

Philadelphia 76ers:  45-37 (4th place, Atlantic Division)

New York Knicks:  53-29 (2nd place, Atlantic Division)

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Philadelphia 76ers:  6-4 last 10

New York Knicks:  7-3 last 10

The 76ers are entering the playoffs with a 45-37 record overall this season and they were 22-19 in their road games where they will be in this game. They are entering this game off a loss against the New York Knicks. Paul George led the team in points in that game with 17 while Joel Embiid was next on the team with 14 points. Quentin Grimes led the team in assists in that game with 4 while Kelly Oubre Jr. led the team in rebounds with 5. They were 41.1% from the field, 36.7% from 3-point range, and 79.4% from the free throw line with their shots in that game. Their offense is averaging 115.9 PPG and their defense is allowing their opponents to average 116.1 PPG against them. The 76ers have an ATS record of 49-42 this season and their O/U record is 43-48.

The Knicks are entering the playoffs with a 53-29 record overall this season and they were 30-10 in their home games where they will be in this game. They are entering this game on a 4 game winning streak with wins coming against the Atlanta Hawks 3 times in a row and the Philadelphia 76ers. Jalen Brunson led the team in points in that game with 35 while OG Anunoby was next on the team with 18 points. Josh Hart and Karl-Anthony Towns each led the team in assists in that game with 6 while Ariel Hukporti led the team in rebounds with 9. They were 63.1% from the field, 51.4% from 3-point range, and 70.6% from the free throw line with their shots in that game. Their offense is averaging 116.5 PPG and their defense is allowing their opponents to average 110.1 PPG against them. The Knicks have an ATS record of 49-41 this season and their O/U record is 42-48.

The current betting odds have the Knicks listed as a 6.5 point favorite in this game according to Draftkings Sportsbook. The Knicks have looked great in their games this season with their 53-29 record overall which had them right near the top of the East. They have looked great on their home court too with their 30-10 home record this season. Meanwhile, the 76ers have looked good in their games this season with their 45-37 record overall which had them right in the middle of the East. They have been a good road team too with their 22-19 road record this year. This is game 2 of a 7-game series between the 3 seeded Knicks and the 7 seeded 76ers in the East for the 2nd round of the NBA playoffs. The Knicks are entering this game with a 1-0 series lead after winning game 1 by a score of 137-98. The Knicks are now 7-3 in their last 10 games and they have been rolling lately. They kicked the Hawks out in the last round with a 4-2 series win and they have a ton of momentum on their side with 4 wins in a row now. They were down 2-1 to the Hawks, but they stepped up big in the last 3 games of that series and now they have been on a tear with 4 wins in a row and all 4 of those wins coming by over 20 points. The Knicks have hot another gear now and with the Celtics out of the playoffs now, they are only going to be more motivated as they look like the team to beat in the East. The 76ers looked great in the 1st round as they were able to erase the 3-1 series deficit against the Celtics and come back to win that series 4-3, but coming back against the Celtics also took a lot out of them. They were still a really up and down team all season and they didn't even show up in the 1st game of this series. The 76ers have been too inconsistent in these playoffs while the Knicks have hit a new level and have looked unstoppable in their last 4 games. The Knicks have also looked like a completely different team on their home court this season, so look for them to continue rolling in this one. The best way to place a bet here is on the Knicks to cover the spread in this game. 

76ers Knicks Prediction:  Our NBA Pick for Wednesday, May 6, 2026 (7:00 pm ET start time) is Knicks 124  76ers 102.

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Philadelphia 76ers: 4-7 ATS revenging a blowout loss vs opponent of 20 points or more. 16-26 ATS versus good offensive teams - scoring 116+ points/game. 22-29 ATS when playing against a team with a winning record. 27-18 UNDER as an underdog. 9-2 UNDER revenging a blowout loss vs opponent of 20 points or more.

New York Knicks: 17-6 ATS after successfully covering the spread in 3 or more consecutive games. 10-3 ATS as a home favorite of 6.5 to 12 points. 17-6 ATS after allowing 100 points or less. 21-11 UNDER off a home win. 29-23 UNDER when playing against a team with a winning record.

Philadelphia 76ers:  None.

New York Knicks:  None.

“They were obviously picking us apart, moving a lot better than we were.” - Nick Nurse after his team’s loss against the Knicks in the 1st game of this series on Monday. 

“Yes, it’s turned into obviously big wins, but those attention to detail things are going to help us in the close ones as well.” - Jalen Brunson after their win against the 76ers in game 1 of this series on Monday. 

PG Tyrese Maxey

SG VJ Edgecombe

SF Kelly Oubre Jr.

PF Paul George

C Joel Embiid

PG Jalen Brunson

SG Josh Hart

SF Mikal Bridges

PF OG Anunoby

C Karl-Anthony Towns

PPG: Tyrese Maxey (28.3)

APG: Tyrese Maxey (6.6)

Reb/G: Andre Drummond (8.4)

PPG: Jalen Brunson (26)

APG: Jalen Brunson (6.8)

Reb/G: Karl-Anthony Towns (11.9)

Coaches:

Philadelphia 76ers: Nick Nurse (3rd season)

New York Knicks: Mike Brown (1st season)