Philadelphia 76ers vs Detroit Pistons Prediction, Preview and Odds - 11/14/2025

Game Time: 7:30 pm ET, Friday, November 14, 2025

Venue:  Little Caesars Arena, Detroit, MI

Where to Watch:  NBCS-P, FDSDT

DraftKings:  Point Spread:  76ers +5.5, Pistons -5.5; Over/Under:  231.5 points

Bet365:  Point Spread:  76ers +5.5, Pistons -5.5; Over/Under:  231.5 points

BetMGM:  Point Spread:  76ers +5.5, Pistons -5.5; Over/Under:  231.5 points

Philadelphia 76ers:  7-4 (2nd place, Atlantic Division)

Detroit Pistons:  10-2 (1st place, Central Division)

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Philadelphia 76ers:  6-4 last 10

Detroit Pistons:  9-1 last 10

The 76ers are entering this game with a 7-4 record overall this season and they are 3-2 in their road games this season where they will be in this game. They are entering this game off a win against the Boston Celtics. Justin Edwards led the team in points in that game with 22 while Tyrese Maxey was next on the team with 21 points. Tyrese Maxey led the team in assists in that game with 9 while Andre Drummond led the team in rebounds with 13. They were 42.9% from the field, 38.9% from 3-point range, and 84.2% from the free throw line with their shots in that game. Their offense is averaging 120.5 PPG and their defense is allowing their opponents to average 116.8 PPG against them. The 76ers have an ATS record of 9-2 this season and their O/U record is 7-4.

The Pistons are entering this game with a 10-2 record overall this season and they are 5-1 in their home games this season where they will be in this game. They are entering this game on an 8 game winning streak with wins coming against the Orlando Magic, the Dallas Mavericks, the Memphis Grizzlies, the Utah Jazz, the Brooklyn Nets, the Philadelphia 76ers, the Washington Wizards, and the Chicago Bulls. Paul Reed led the team in points in that game with 28 while Duncan Robinson was next on the team with 23 points. Daniss Jenkins led the team in assists in that game with 12 while Paul Reed led the team in rebounds with 13. They were 55.6% from the field, 43.3% from 3-point range, and 68.8% from the free throw line with their shots in that game. Their offense is averaging 118.5 PPG and their defense is allowing their opponents to average 112.8 PPG against them. The Pistons have an ATS record of 8-4 this season and their O/U record is 6-5-1.

The current betting odds have the Pistons listed as a 5.5 point favorite in this game according to Draftkings Sportsbook. The Pistons have looked great in their games this season with their 10-2 record overall which has them right at the top of the East with one of the best records in the entire NBA. They have looked great on their home court too with their 5-1 home record this season and they are also 1-0 in the NBA Cup group stage. Meanwhile, the 76ers have looked good in their games this season with their 7-4 record overall which has them right near the top of the East with a good start to the season. They have been a good road team so far with their 3-2 road record, but they are 0-1 in the NBA Cup group stage. They are off a win over the Celtics in their last one, but they have been dealing with some injuries lately and that has led to them cooling off a bit from a really hot start. The Pistons are also dealing with some injuries, but they continue to find ways to win games while missing key players. They have a lot more momentum on their side with 8 wins in a row now too and they already have a win over the 76ers this season too. The Pistons are one of the best teams in the East right now and they are going to bring their best effort to stay at the top of this group. The best way to place a bet here is on the Pistons to cover the spread in this game. 

76ers Pistons Prediction:  Our NBA Pick for Friday, November 14, 2025 (7:30 pm ET start time) is Pistons 114  76ers 108.

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Philadelphia 76ers: 24-8 ATS after successfully covering the spread in 3 or more consecutive games. 25-17 ATS off a home win. 33-22 ATS versus good teams - outscoring their opponents by 3+ points/game. 14-6 OVER when playing against a top-level team (Win Pct. > 70%).

Detroit Pistons: 3-8 ATS off an upset win as a home underdog. 0-4 ATS off an upset win over a division rival as an underdog. 13-21 ATS at home versus poor defensive teams - allowing 116+ points/game. 11-2 OVER off an upset win as a home underdog.

Philadelphia 76ers:  P. George (PF) Out - Knee. J. Broome (PF) Day To Day - Ankle. D. Barlow (SF) Day To Day - Elbow. J. Embiid (C) Day To Day - Knee.

Detroit Pistons:  C. Cunningham (PG) Day To Day - Hip. J. Duren (C) Day To Day - Ankle. A. Thompson (SF) Day To Day - Ankle. I. Stewart (C) Day To Day - Ankle. T. Harris (PF) Day To Day - Ankle. M. Sasser (PG) Out - Hip. J. Ivey (SG) Out - Knee.

"We still are going into these games with three or four rotational guys out. Like, I think last year, we were going six or seven rotational guys out, but it’s a different team for sure and the fact that we got some youth and speed and we’re able to go out there and scrap with some intensity and play hard and all that kind of stuff and give ourselves a chance, that’s all I keep saying." - Nick Nurse on his team fighting through injuries.

"He was impactful all over the floor. He just did not want to disappoint, that's all it came down to. He did not want to let his teammates down." - J.B. Bickerstaff after his team’s win against the Bulls in their game on Wednesday.

PG Tyrese Maxey

SG VJ Edgecombe

SF Kelly Oubre Jr.

PF Trendon Watford

C Joel Embiid

PG Cade Cunningham

SG Duncan Robinson

SF Ausar Thompson

PF Tobias Harris

C Jalen Duren 

PPG: Tyrese Maxey (32.1)

APG: Tyrese Maxey (8.3)

Reb/G: Andre Drummond (8.6)

PPG: Cade Cunningham (27.5)

APG: Cade Cunningham (9.9)

Reb/G: Jalen Duren (12)

Coaches:

Philadelphia 76ers: Nick Nurse (3rd season)

Detroit Pistons: J.B. Bickerstaff (2nd season)