Philadelphia 76ers vs Detroit Pistons Prediction, Preview and Odds - 03/12/2026

Game Time: 7:00 pm ET, Thursday, March 12, 2026

Venue:  Little Caesars Arena, Detroit, MI 

Where to Watch:  Prime Video

DraftKings:  Point Spread:  76ers +14.5, Pistons -14.5; Over/Under:  221.5 points

Bet365:  Point Spread:  76ers +14.5, Pistons -14.5; Over/Under:  221.5 points

BetMGM:  Point Spread:  76ers +14.5, Pistons -14.5; Over/Under:  221.5 points

Philadelphia 76ers:  35-30 (4th place, Atlantic Division)

Detroit Pistons:  46-18 (1st place, Central Division)

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Philadelphia 76ers:  5-5 last 10

Detroit Pistons:  5-5 last 10

The 76ers are entering this game with a 35-30 record overall this season and they are 17-14 in their road games this season where they will be in this game. They are entering this game off a win against the Memphis Grizzlies. Cameron Payne led the team in points in that game with 32 while Kelly Oubre Jr. was next on the team with 30 points. Cameron Payne led the team in assists in that game with 10 while Kelly Oubre Jr. led the team in rebounds with 12. They were 52.3% from the field, 35.5% from 3-point range, and 82.6% from the free throw line with their shots in that game. Their offense is averaging 115.9 PPG and their defense is allowing their opponents to average 116.3 PPG against them. The 76ers have an ATS record of 35-30 this season and their O/U record is 34-31.

The Pistons are entering this game with a 46-18 record overall this season and they are 23-8 in their home games this season where they will be in this game. They are entering this game off a win against the Brooklyn Nets. Jalen Duren led the team in points in that game with 26 while Cade Cunningham was next on the team with 21 points. Cade Cunningham led the team in assists in that game with 15 while Isaiah Stewart led the team in rebounds with 8. They were 56.5% from the field, 50% from 3-point range, and 76.5% from the free throw line with their shots in that game. Their offense is averaging 117 PPG and their defense is allowing their opponents to average 109.6 PPG against them. The Pistons have an ATS record of 32-32 this season and their O/U record is 27-36-1.

The current betting odds have the Pistons listed as a 14.5 point favorite in this game according to Draftkings Sportsbook. The Pistons have looked great in their games this season with their 46-18 record overall which has them right at the top of the East with one of the best records in the entire NBA. They have looked great on their home court too with their 23-8 home record this season. Meanwhile, the 76ers have looked good in their games this season with their 35-30 record overall which has them right in the middle of the East. They have been a good road team too with their 17-14 road record this year. The 76ers have been a better road team this season than they have been a home team, but lately they haven't looked that great. They are off a win over the Grizzlies in their last one, but they are only 5-5 in their last 10 games and they have been dealing with some injuries to some of their starters. They have already been missing George and Embiid lately, but now they will be without Maxey too and that is a huge blow since he has really been the backbone of the team this year. The Pistons haven't looked any better lately themselves, going 5-5 in their last 10 games, but they have also been a bit banged up lately too. Now they are a bit healthier and just bounced back in their last one after going on their first 4 game losing streak of the season, coming off a huge win over the Nets now. The Pistons have some momentum again and they will be looking to string together 2 wins after going on that bad stretch. Look for the Pistons to take advantage of a banged up 76ers team that hasn't looked great lately. The best way to place a bet here is on the Pistons to cover the spread in this game. 

76ers Pistons Prediction:  Our NBA Pick for Thursday, March 12, 2026 (7:00 pm ET start time) is Pistons 128  76ers 110.

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Philadelphia 76ers: 8-4 ATS against Central division opponents. 19-10 ATS in road games. 5-1 ATS after scoring 136 points or more. 9-5 UNDER against Central division opponents. 6-2 UNDER when playing against a top-level team (Win Pct. > 70%).

Detroit Pistons: 1-5 ATS off a road blowout win by 20 points or more. 23-31 ATS when playing against a marginal winning team (Win Pct. 51% to 60%). 4-9 ATS versus teams who average 9 or more steals/game on the season. 9-3 UNDER when playing against a marginal winning team (Win Pct. 51% to 60%). 8-2 UNDER after allowing 100 points or less.

Philadelphia 76ers:  T. Maxey (PG) Out - Finger. J. Embiid (C) Out - Oblique. J. Broome (PF) Out - Knee.

Detroit Pistons:  C. LeVert (SG) Day To Day - Wrist. A. Thompson (SF) Day To Day - Ankle.

"I really thought VJ gave us a huge spark. He just all of a sudden started getting offensive rebounds and putbacks. I thought he, leadership-wise, with his energy, kind of really sparked that run with some of his tough plays he was making." - Nick Nurse after his team’s win against the Grizzlies in their game on Tuesday.

“We did what we were supposed to do, and it’s that simple. Tonight, guys had their mind made up that we were going to go out there and take care of business.” - J.B. Bickerstaff after his team’s win against the Nets in their game on Tuesday.

PG Cameron Payne

SG VJ Edgecombe

SF Kelly Oubre Jr.

PF Dominick Barlow

C Adem Bona

PG Cade Cunningham

SG Duncan Robinson

SF Javonte Green

PF Tobias Harris

C Jalen Duren

PPG: Tyrese Maxey (29)

APG: Tyrese Maxey (6.7)

Reb/G: Andre Drummond (8.4)

PPG: Cade Cunningham (25.1)

APG: Cade Cunningham (9.9)

Reb/G: Jalen Duren (10.6)

Coaches:

Philadelphia 76ers: Nick Nurse (3rd season)

Detroit Pistons: J.B. Bickerstaff (2nd season)