Philadelphia 76ers vs Boston Celtics Prediction, Preview and Odds - 04/28/2026

Game Time: 7:00 pm ET, Tuesday, April 28, 2026

Venue:  TD Garden, Boston, MA

Where to Watch:  ESPN

DraftKings:  Point Spread:  76ers +11.5, Celtics -11.5; Over/Under:  215.5 points

Bet365:  Point Spread:  76ers +11.5, Celtics -11.5; Over/Under:  214.5 points

BetMGM:  Point Spread:  76ers +11.5, Celtics -11.5; Over/Under:  214.5 points

Philadelphia 76ers:  45-37 (4th place, Atlantic Division)

Boston Celtics:  56-26 (1st place, Atlantic Division)

Do not miss out on our expert handicapper analysis! Nelly’s Sports is on a HOT STREAK in the NBA on a 7-0 NBA RUN for +$7,000 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Philadelphia 76ers:  4-6 last 10

Boston Celtics:  8-2 last 10

The 76ers are entering the playoffs with a 45-37 record overall this season and they were 22-19 in their road games where they will be in this game. They are entering this game on a 2 game losing streak with losses coming against the Boston Celtics. Joel Embiid led the team in points in that game with 26 while Tyrese Maxey was next on the team with 22 points. Joel Embiid, Tyrese Maxey, and Quentin Grimes each led the team in assists in that game with 6 while Joel Embiid led the team in rebounds with 10. They were 41.3% from the field, 30% from 3-point range, and 87.5% from the free throw line with their shots in that game. Their offense is averaging 115.9 PPG and their defense is allowing their opponents to average 116.1 PPG against them. The 76ers have an ATS record of 46-41 this season and their O/U record is 41-46.

The Celtics are entering the playoffs with a 56-26 record overall this season and they were 30-11 in their home games where they will be in this game. They are entering this game on a 2 game winning streak with wins coming against the Philadelphia 76ers twice in a row. Payton Pritchard led the team in points in that game with 32 while Jayson Tatum was next on the team with 30 points. Jayson Tatum led the team in assists in that game with 11 while Neemias Queta led the team in rebounds with 8. They were 48.3% from the field, 45.3% from 3-point range, and 71.4% from the free throw line with their shots in that game. Their offense is averaging 114.9 PPG and their defense is allowing their opponents to average 107.2 PPG against them. The Celtics have an ATS record of 51-35 this season and their O/U record is 31-55.

The current betting odds have the Celtics listed as an 11.5 point favorite in this game according to Draftkings Sportsbook. The Celtics have looked great in their games this season with their 56-26 record overall which had them right near the top of the East with one of the best records in the entire NBA. They have looked great on their home court too with their 30-11 home record this season. Meanwhile, the 76ers have looked good in their games this season with their 45-37 record overall which had them right in the middle of the East. They have been a good road team too with their 22-19 road record this year. This is game 5 of a 7-game series between the 2 seeded Celtics and the 7 seeded 76ers in the East for the 1st round of the NBA playoffs. The Celtics are entering this game with a 3-1 series lead after winning game 4 by a score of 128-96. Joel Embiid finally came back for the 76ers in game 4, but it really didn't matter with the Celtics still in complete control of that one. The 76ers suffered one of their worst losses in this series with Embiid back in the lineup and they also got crushed in both of their home games. Their offense has had a lot of trouble putting up points in this series too. They did get their 1 win in this series on the road, but that was also a bad shooting night for the Celtics and they have looked a lot better in the last 2 games since then. Now the Celtics are rolling again and going back home with a chance to end the series here, so look for them to bring their best effort to close this one out. They have already had 2 of their 3 wins in this series come by over 30 points too and the 76ers just don't have the talent to slow them down here. The best way to place a bet here is on the Celtics to cover the spread in this game. 

76ers Celtics Prediction:  Our NBA Pick for Tuesday, April 28, 2026 (7:00 pm ET start time) is Celtics 117  76ers 99.

Don't miss our champion handicappers free picks and expert basketball picks today.  And if you enjoyed this Philadelphia 76ers Boston Celtics prediction, be sure to drop by every day for our weekly NBA predictions and previews.

Philadelphia 76ers: 3-6 ATS revenging a blowout loss vs opponent of 20 points or more. 7-13 ATS when playing against a good team (Win Pct. 60% to 70%). 11-18 ATS versus good teams - outscoring their opponents by 3+ points/game. 18-10 UNDER revenging a same season loss vs opponent. 19-11 UNDER versus good teams - outscoring their opponents by 3+ points/game.

Boston Celtics: 15-8 ATS as a favorite of 10 or more points. 42-22 ATS versus good shooting teams - making 46% of their shots or more.16-6 ATS when playing against a marginal winning team (Win Pct. 51% to 60%). 24-12 UNDER as a home favorite. 31-14 UNDER when playing against a team with a winning record.

Philadelphia 76ers:  None.

Boston Celtics:  None.

“That can't happen. That's on me. That's just unacceptable by me. I was playing within the flow of the game. It kind of happened that way. It wasn't meant to happen that way.” - Tyrese Maxey after their loss against the Celtics in the 4th game of this series on Sunday. 

“He’s just a guy that finds the game. He dictates the pace for us. He did a good job of that for himself and others tonight. When we’re at our best, he’s aggressive.” - Joe Mazzulla after his team’s win against the 76ers in game 4 of this series on Sunday. 

PG Tyrese Maxey

SG VJ Edgecombe

SF Kelly Oubre Jr.

PF Paul George

C Joel Embiid

PG Derrick White 

SG Jaylen Brown 

SF Sam Hauser

PF Jayson Tatum

C Neemias Queta

PPG: Tyrese Maxey (28.3)

APG: Tyrese Maxey (6.6)

Reb/G: Andre Drummond (8.4)

PPG: Jaylen Brown (28.7)

APG: Derrick White (5.4)

Reb/G: Jayson Tatum (10)

Coaches:

Philadelphia 76ers: Nick Nurse (3rd season)

Boston Celtics: Joe Mazzulla (4th season)