Oregon Ducks vs USC Trojans Prediction, Picks and Game Preview - 09/26/2026

Game Time: 7:30 pm ET, Saturday, September 26, 2026

Venue:  LA Memorial Coliseum, Los Angeles, CA 

Where to Watch:  NBC

DraftKings:  Point Spread:  Oregon -3, USC +3; Over/Under:  62.5 points

Bet365:  Point Spread:  Oregon -3, USC +3; Over/Under:  62.5 points

BetMGM:  Point Spread:  Oregon -3, USC +3; Over/Under:  62.5 points

Oregon Ducks:  2-1 (0-0) (10th place, Big Ten)

USC Trojans:  4-0 (1-0) (1st place, Big Ten)

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Oregon Ducks:  won their last game at home against the Portland State Vikings 84-0.

USC Trojans:  won their last game on the road against the Rutgers Scarlet Knights 42-35.

Oregon is entering this game with a 2-1 record overall and they have a 0-0 record in their conference games too. They are 2-0 in their home games, 0-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Portland State 84-0. Dante Moore was the starting QB and he completed 19/23 passes for 280 passing yards, 4 touchdowns, and 0 interceptions. Brandon Smith led the team in rushing yards with 85 and 1 TD. Evan Stewart led the receivers with 72 receiving yards on 3 receptions and 1 TD. Matthew Johnson and Bear Alexander each led the defense in that game with 3 tackles while Aydin Breland and Matayo Uiagalelei each led the defense in sacks with 1. Jett Washington came away with 2 interceptions for them while Davon Benjamin came away with 1 INT in that one.

 

 

 

USC is entering this game with a 4-0 record overall and they have a 1-0 record in their conference games too. They are 3-0 in their home games, 1-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against Rutgers 42-35. Jayden Maiava was the starting QB and he completed 20/32 passes for 277 passing yards, 2 touchdowns, and 0 interceptions. King Miller led the team in rushing yards with 102 and 1 TD. Kayden Dixon-Wyatt led the receivers with 77 receiving yards on 5 receptions. Christian Pierce led the defense in that game with 11 tackles while Kameryn Crawford and Desman Stephens II each led the defense in sacks with 0.5. Christian Pierce and Prophet Brown each came away with 1 interception for them in that one.

The current betting odds have USC listed as a 3 point underdog in this game according to Draftkings Sportsbook. USC has looked great in their games this season with their 4-0 record overall and their 1-0 conference record which has them right at the top of the Big Ten. They have looked great on their home field too with their 3-0 home record this season. Meanwhile, Oregon has looked good in their games this season with their 2-1 record overall so far. They haven't been a great road team though with their 0-1 road record so far. Oregon is coming off an 84-0 win over a team from the FCS, but they did lose their only road game this year to Oklahoma State. They looked terrible in that 39-31 loss and they didn't look great in their season opener either, barely winning at home against Boise State after trailing for a lot of that game. USC has looked great in their 4 games though and their offense has been rolling as usual. They are coming off a 42-35 win over Rutgers in their last one and didn't look great, but that was also a tough travel game for them with this game on deck, especially against a terrible opponent who was desperate to turn things around. They are going to bring their best effort for this game though and Lincoln Riley finally has a chance to get a statement win that could propel this team to the CFP this year. Their defense hasn't looked great, but they have a lot of talent that they haven't had in previous years and this Oregon defense hasn't looked that great either. Look for USC to take advantage of how bad Oregon has been to start the season and finally jump on their chance to get a big win in the Big Ten. The best way to place a bet here is on USC to cover the spread in this game. 

Oregon USC Prediction:  Our NCAAF Pick for Saturday, September 26, 2026 (7:30 pm ET start time) is USC 45 Oregon 41.

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Oregon Ducks: 54-29 ATS when the line is +3 to -3. 39-25 ATS off a home blowout win by 28 points or more. 62-44 ATS after allowing 14 points or less last game. 21-14 OVER as a road favorite of 7 points or less. 35-25 OVER off a home blowout win by 28 points or more.

USC Trojans: 45-62 ATS when the total is between 56.5 and 63. 45-63 ATS after 3 or more consecutive straight up wins. 24-36 ATS against teams with a turnover margin of +1 per game or better. 31-19 OVER in a home game where the total is between 56.5 and 63. 30-23 OVER against teams with a turnover margin of +1 per game or better.

Oregon Ducks:  J. Lott (WR) Doubtful - Hand. K. Harrison (TE) Probable - Undisclosed. J. Johnson (TE) Probable - Undisclosed. J. McClellan (WR) Out - Foot. D. Gresham (WR) Questionable - Neck. S. Price (RB) Questionable - Undisclosed. I. Hooks (WR) Questionable - Undisclosed.

USC Trojans:  C. Simms (WR) Out - Undisclosed. K. Reddick (S) Questionable - Undisclosed. D. Redeaux (RB) Probable - Undisclosed. T. Mosley (WR) Out - Knee. S. Huard (QB) Questionable - Undisclosed. R. Tezeno (WR) Questionable - Foot. R. Ison (WR) Questionable - Undisclosed. K. O'Connor (OG) Out - Undisclosed.

“Obviously, the result of this game is somewhat to be expected. We have a better team, and no disrespect to Portland State, but that’s what that’s the way it should look when you execute the way we’re supposed to execute.” - Dan Lanning after his team’s win against Portland State in their last game. 

“We obviously had to play with a lot of different guys in the secondary. We had some guys go down throughout the game that weren’t available. I thought we were untimely as a defense." - Lincoln Riley after his team’s win against Rutgers in their last game. 

WR McClellan, Jeremiah

WR Moore, Dakorien

WR Stewart, Evan

TE Olesh, Andrew

QB Moore, Dante

RB Davison, Jordon

WR Simms, Corey

WR Dixon-Wyatt, Kayden

WR Williams, Zacharyus

TE Bowman, Mark

QB Maiava, Jayden

RB Miller, King

Passing: Dante Moore (849)

Rushing: Jordon Davison (194)

Receiving: Evan Stewart (222)

Touchdowns: Jordon Davison (4)

Passing: Jayden Maiava (1,173)

Rushing: King Miller (338)

Receiving: Kayden Dixon-Wyatt (258)

Touchdowns: Trent Mosley (4)

Coaches:

Oregon Ducks: Dan Lanning (5th season)

USC Trojans: Lincoln Riley (5th season)