by Rod Pearson
Monday, Dec 08, 2025
Game Time: 5:00 pm ET, Wednesday, December 17, 2025
Venue: Camping World Stadium, Orlando, FL
Where to Watch: ESPN
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: ODU +7, USF -7; Over/Under: 56.5 points
Bet365: Point Spread: ODU +6.5, USF -6.5; Over/Under: 57 points
BetMGM: Point Spread: ODU +6.5, USF -6.5; Over/Under: 56.5 points
Season Record
Old Dominion Monarchs: 9-3 (6-2) (2nd place, Sun Belt East)
South Florida Bulls: 9-3 (6-2) (4th place, American)
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Recent Form
Old Dominion Monarchs: won their last game at home against the Georgia State Panthers 27-10.
South Florida Bulls: won their last game at home against the Rice Owls 52-3.
Old Dominion Monarchs vs South Florida Bulls Preview and Analysis
Old Dominion is entering this game with a 9-3 record overall and they have a 6-2 record in their conference games too. They are 6-0 in their home games, 3-3 in their road games, and they are also 0-0 in their neutral site games this season, and they will be at a neutral site for this game. They won their last game against GA State 27-10. Colton Joseph was the starting QB and he completed 9/22 passes for 106 passing yards, 0 touchdowns, and 1 interception. Devin Roche led the team in rushing yards with 137 and 2 TDs. Ja'Cory Thomas led the receivers with 64 receiving yards on 4 receptions. Zion Frink led the defense in that game with 5 solo tackles and 5 assisted tackles while Hunter Malecki led the defense in sacks with 1. Seth Naotala came away with the only interception for them in that one.
South Florida is entering this game with a 9-3 record overall and they have a 6-2 record in their conference games too. They are 6-0 in their home games, 3-3 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at a neutral site for this game. They won their last game against Rice 52-3. Byrum Brown was the starting QB and he completed 16/24 passes for 275 passing yards, 4 touchdowns, and 0 interceptions. Byrum Brown led the team in rushing yards with 104 and 1 TD. Keshaun Singleton led the receivers with 125 receiving yards on 6 receptions and 2 TDs. Mac Harris led the defense in that game with 5 solo tackles and 0 assisted tackles while Josh Celiscar led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.
Old Dominion vs South Florida Prediction
The current betting odds have Old Dominion listed as a 7 point underdog in this game according to Draftkings Sportsbook. Old Dominion has looked really good in their games this season with their 9-3 record overall and their 6-2 conference record which had them right near the top of their division in the Sun Belt, right behind James Madison. They haven't played in a neutral site game this season so this will be their first, playing in the Cure Bowl. Meanwhile, South Florida has looked really good in their games this season with their 9-3 record overall and their 6-2 conference record which had them right near the top of the American Conference. They haven't played in a neutral site game this season either, and their season ended in a lot of disappointment for them. They had a great start to the season with wins over Boise State and Florida, looking like they were going to be a big threat in the American Conference. They were ranked inside the top 25 at times and were talked about as a playoff team for a lot of the season, but they ended up tripping up twice in the conference, despite having some really good wins, and it wasn't enough for them to even get into the championship game. Now their head coach is gone, taking the Auburn job, and it is tough to see their motivation when they aren't playing in the CFP like they expected to early on in the year. Old Dominion also just missed out on their conference championship game due to James Madison being so good, but ODU played some good opponents in tight games this year and they still have a head coach to lead them in this game. There is too much uncertainty surrounding this USF team when ODU has a good team that is going to bring their best effort here. The best way to place a bet here is on Old Dominion to cover the spread in this game.
Old Dominion South Florida Prediction: Our NCAAF Pick for Wednesday, December 17, 2025 (5:00 pm ET start time) is Old Dominion 31 South Florida 24.
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NCAAF Betting Trends
Old Dominion Monarchs: 5-1 ATS as an underdog of 3.5 to 10 points. 7-2 ATS after allowing 14 points or less last game. 7-3 ATS off a home win. 10-5 OVER when playing against a team with a winning record. 10-6 OVER after playing a game at home.
South Florida Bulls: 1-4 ATS as a favorite of 3.5 to 10 points. 1-4 ATS vs. good passing teams averaging 8 or more passing yards/att. 3-7 ATS versus good rushing teams - averaging 4.75 rushing yards/carry or more. 13-4 OVER as a favorite. 9-4 OVER off a win against a conference rival.
Key Injuries
Old Dominion Monarchs: K. Naotala (LB) Questionable - Undisclosed. T. Myers (WR) Questionable - Undisclosed. C. Drake (OG) Questionable - Undisclosed. B. Alisandro (CB) Questionable - Undisclosed. M. James (RB) Questionable - Undisclosed. J. Henderson (LB) Out - Undisclosed.
South Florida Bulls: K. Pettigrew (WR) Questionable - Undisclosed. J. Jenkins (OG) Questionable - Undisclosed. I. Guy (CB) Questionable - Undisclosed. D. Bowman (OG) Questionable - Undisclosed. D. Flowers (DL) Questionable - Undisclosed. T. Ward (S) Questionable - Undisclosed. C. Neptune (WR) Questionable - Undisclosed. C. Nimrod (WR) Questionable - Undisclosed. J. Chenault (CB) Questionable - Undisclosed. G. Otten (LB) Out - Undisclosed. B. Silvera (CB) Out - Undisclosed. C. Norton (RB) Out - Undisclosed.
Notable Quotes
“We have so many coaches with young kids and to be able to go down there for our players, I’m really excited about this. It’s a perfect opportunity. I love the timing, the location, and very bluntly, I’m excited about the opponent.” - Ricky Rahne on his team playing in the Cure Bowl.
"We are excited to go and finish this season strong against a very good Old Dominion team in the Cure Bowl. Our guys are preparing for the opportunity to post a third straight bowl win and to compete for a 10th win on the year, something that has only been accomplished here two other times." - Kevin Patrick on his team playing in the Cure Bowl.
Starting Lineups
Old Dominion Monarchs
WR Thomas, Ja'Cory
WR Brown III, Tre
WR Abdul-Rahim Gladding, Na'eem
TE Butler, Jailen
QB Joseph, Colton
RB James, Maurki
South Florida Bulls
WR Nimrod, Chas
WR Singleton, Keshaun
WR Reuben, Mudia
TE Sullivan, Wyatt
QB Brown, Byrum
RB Davenport, Nykahi
Statistical Leaders
Old Dominion Monarchs
Passing: Colton Joseph (2,624)
Rushing: Colton Joseph (1,007)
Receiving: Tre' Brown III (751)
Touchdowns: Colton Joseph (13)
South Florida Bulls
Passing: Byrum Brown (3,158)
Rushing: Byrum Brown (1,008)
Receiving: Keshaun Singleton (877)
Touchdowns: Byrum Brown (14)
Coaches:
Old Dominion Monarchs: Ricky Rahne (6th season)
South Florida Bulls: Kevin Patrick (Interim)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
