Oklahoma State Cowboys vs Iowa State Cyclones Prediction, Picks and Game Preview - 01/10/2026

Game Time: 4:00 pm ET, Saturday, January 10, 2026

Venue:  Hilton Coliseum, Ames, IA

Where to Watch:  ESPN2

DraftKings:  Point Spread:  OK State +19.5, ISU -19.5; Over/Under:  165.5 points

Bet365:  Point Spread:  OK State +19.5, ISU -19.5; Over/Under:  165.5 points

BetMGM:  Point Spread:  OK State +19.5, ISU -19.5; Over/Under:  165.5 points

Oklahoma State Cowboys:  13-2 (1-1) (7th place, Big 12)

Iowa State Cyclones:  15-0 (2-0) (2nd place, Big 12)

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Oklahoma State Cowboys:  4-1  last 5

Iowa State Cyclones:  5-0  last 5

Oklahoma State is entering this game with a 13-2 record overall, a 1-1 record in conference games, and they are 0-1 in their road games this season where they will be in this game. They are coming off a win against the UCF Knights in their last game. Parsa Fallah led the team in points in that game with 24 while Kanye Clary was next on the team with 18. Kanye Clary led the team in assists with 8 in that game while Kanye Clary led the team in rebounds with 9. They were 47.2% from the field, 52.6% from 3-point range, and 77.1% from the free throw line with their shooting in that game. Their offense is averaging 90.2 PPG and their defense is allowing their opponents to average 79.7 PPG against them. Oklahoma State has an ATS record of 7-8 this season and their O/U record is 9-6.

Iowa State is entering this game with a 15-0 record overall, a 2-0 conference record, and they are 9-0 in their home games this season where they will be in this game. They are coming off a win against the Baylor Bears in their last game. Tamin Lipsey led the team in points in that game with 24 while Joshua Jefferson was next on the team with 19. Joshua Jefferson and Killyan Toure each led the team in assists with 3 in that game while Joshua Jefferson led the team in rebounds with 17. They were 40.6% from the field, 31.6% from 3-point range, and 60% from the free throw line with their shooting in that game. Their offense is averaging 88.3 PPG and their defense is allowing their opponents to average 62.4 PPG against them. Iowa State has an ATS record of 9-5-1 this season and their O/U record is 8-7.

The current betting odds have Iowa State listed as a 19.5 point favorite in this game according to Draftkings Sportsbook. Iowa State has looked great in their games this season with their 15-0 record overall and their 2-0 conference record which has them right near the top of the Big 12. They have looked great on their home court too with their 9-0 home record this season. Meanwhile, Oklahoma State has looked good in their games this season with their 13-2 record overall and their 1-1 conference record which has them in the top half of the Big 12. They haven't been a great road team so far though, going 0-1 in their road games this season. Oklahoma State has had a great start to the season, but they have also struggled against some weaker opponents this year, and they haven't had a strong schedule to start the season either. They have been getting by beating up on lesser opponents, but they have lost badly against better opponents. They have a 9 point loss to Oklahoma and they also lost their only road game in the Big 12 to Texas Tech by 22 points, not even being competitive in the game. Iowa State has been rolling all year as they are one of the few undefeated teams left in the nation. They haven't had an easy schedule either, picking up some good wins against really good opponents, and they have even embarrassed some ranked opponents this year. They are off a big road win over Baylor by double digits in their last one, and they are going to continue rolling at home here against an Oklahoma State team that has benefited from a weak schedule. The best way to place a bet here is on Iowa State to cover the spread in this game. 

Oklahoma State Iowa State Prediction:  Our NCAAB Pick for Saturday, January 10, 2026 (4:00 pm ET start time) is Iowa State 90 Oklahoma State 66.

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Oklahoma State Cowboys: 2-6 ATS when the total is 160 to 169.5. 15-26 ATS after playing a home game. 14-24 ATS versus very good teams - outscoring their opponents by 8+ points/game. 8-3 OVER off a win against a conference rival. 30-14 OVER after playing a home game.

Iowa State Cyclones: 54-30 ATS in all games. 23-14 ATS as a favorite of 10 or more points. 21-9 ATS off a win against a conference rival. 7-2 OVER after a game where they allowed a shooting pct. of 33% or less. 7-1 OVER versus poor defensive teams - allowing 77+ points/game.

Oklahoma State Cowboys:  L. Mantzoukas (F) Questionable - Undisclosed. C. Coleman (G) Questionable - Illness. R. Jennings (F) Out - Hip.

Iowa State Cyclones:  E. Mulder (F) Probable - Undisclosed. X. Mitchell (F) Probable - Undisclosed. M. Williams (G) Out - Hip.

“Saturday at Lubbock was very disappointing, and that one hurt because I expected us to compete. And Texas Tech’s really good, and Central Florida’s really good as well, but I expected us to compete better, and I thought that the competitive side of our basketball game tonight was much better. And anytime we can do that, I think we’re gonna give ourselves an opportunity.” - Steve Lutz after his team’s win against UCF in their last game. 

“They're incredibly fast in transition, multiple playmaking guards that can really get out and push the pace. They're a team that takes tremendous pride in attacking and reattacking and getting into the paint and getting to the rim and the foul line.” - T. J. Otzelberger on his team’s upcoming game against Oklahoma State.

K. Clary 

P. Fallah 

L. Mantzoukas 

V. Miller 

A. Roy

B. Buchanan 

J. Jefferson 

T. Lipsey 

M. Momcilovic 

K. Toure

PPG: Anthony Roy (17.5)

APG: Kanye Clary (4.9)

Reb/G: Parsa Fallah (5.9)

PPG: Joshua Jefferson (17.6)

APG: Tamin Lipsey (5.6)

Reb/G: Joshua Jefferson (7.9)

Coaches:

Oklahoma State Cowboys: Steve Lutz (2nd season)

Iowa State Cyclones: T.J. Otzelberger (5th season)